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Abstract

Background

Lebanon has an increasing cancer burden. Sufficient knowledge of cancer risk factors and early cancer symptoms can help lower cancer burden by facilitating primary prevention and early diagnosis. This study (i) assessed Lebanese adults’ knowledge and beliefs of cancer risk factors and early cancer symptoms, (ii) analyzed whether knowledge was correlated with personal behavior, and (iii) assessed the presence of barriers that keep knowledge from turning into healthcare seeking behavior.

Methods

We performed a cross-sectional survey in the Lebanese adult population, consisting of a questionnaire administered during face-to-face interviews on a community-based non-probability sample (n = 726) that was frequency matched to national government estimates on age, level of education and gender.

Results

Recognition was high for carcinogens and protective factors (75%), but low for neutral factors (22%) which were often seen as carcinogenic. A quarter of participants (27.8%) could not name any early warning signs. For some risk factors, high knowledge scores were correlated with low-risk behavior, but this was not the case for cigarette smoking. The most frequent barriers for not seeking timely care were financial (57.0%) fear of finding illness (53.7%), and having other things to worry about (42.4%).

Conclusion

This study revealed important knowledge gaps which are likely to hamper primary prevention and early diagnosis. However, we also showed that high knowledge of risk was not always correlated with low-risk behavior. This, together with the barriers we found that kept people from seeking timely health care, emphasizes that efforts to lower cancer burden should not only focus on increasing knowledge.

Keywords

cancer prevention tobacco control risk factors population epidemiology cancer risk cancer knowledge and beliefs health promotion

Background

Lebanon has the highest cancer incidence rates in the Eastern Mediterranean Region and is in the top quartile of cancer incidence worldwide.¹ The most common cancers among Lebanese males are prostate cancer (17.7%), followed by lung cancer (15.4%), colorectal cancer (9.6%), and bladder cancer (8.0%). The most common cancers among Lebanese females are breast cancer (33.7%), lung cancer (8.7%), colorectal cancer (6.0%), and thyroid cancer (5.2%). These top 4 locations account for more than half of all cancers (50.7% for males, 53.6% for females).² Although cancer burden is projected to increase over the next years, primary prevention, screening, and early diagnosis can help lower cancer burden.³

Primary Prevention

A third (33%) of all cancers in adults in the Eastern Mediterranean Region can be avoided because avoidable carcinogenic factors in our lifestyle are the driving force behind them (such as tobacco, alcohol, and low physical activity).^4-7 Eliminating these carcinogenic factors (primary prevention) is therefore an effective tool to lower cancer burden. This requires that the population has sufficient knowledge of these cancer risk factors, while barriers that keep this knowledge from turning into action are simultaneously minimized.⁸ Research that assessed knowledge and beliefs of cancer risk factors in Lebanon is scarce. Although some local and national organizations had initiatives to increase knowledge, but exposure to lifestyle risk factors is increasing rather than decreasing.^2,6,9 Previous studies found that only 34% of Lebanese adults were aware of the cancer risks of human papillomavirus (HPV),¹⁰ 36.5% are aware that physical inactivity is a risk factor for colorectal cancer,¹¹ alcohol is identified as a risk factor for colorectal cancer by 52.8% of Lebanese adults,¹¹ 51.4% of Lebanese adults are aware that being overweight is a risk factor for cancer,¹² and only 30.1% know tobacco is the biggest risk factor for bladder cancer.¹³

Screening and Early Diagnosis

Screening (diagnosing illness before symptoms are present) and early diagnosis (diagnosing illness at the first sign of symptoms) also have the potential to lower cancer burden. World Health Organization (WHO) recommends that countries use early diagnosis for all cancers.⁴ In order for a population to use screening and early diagnosis, knowledge of cancer, the possibility of screening, and early cancer symptoms should be optimized. At the same time, barriers to care that could keep this knowledge from turning into action need to be minimized (financial, logistical, or psychosocial barriers that keep someone from seeing a doctor).^8,14,15

Research that investigated barriers to cancer screening in Lebanon found that 63.6% of the Lebanese citizens were aware of the screening program for breast cancer and 40.8% was aware screening for cervical cancer is possible.¹⁵ Those results were in line with the weighted national prevalence of “ever-use” of the Pap smear for screening purposes, which was estimated at 35%.¹⁶

Aim

This study aimed to (i) assess Lebanese adults’ knowledge and beliefs of cancer risk factors and early cancer symptoms; (ii) analyze whether knowledge of the risk posed by cigarettes, waterpipe, alcohol, and lack of physical exercise is correlated with personal behavior on those factors; and (iii) assess the presence of barriers that keep knowledge of early cancer symptoms from turning action (seeking health care for early diagnosis).

Materials and Methods

We performed a cross-sectional survey in the general adult population in 2019. The survey consisted of a questionnaire that was administered by investigators during face-to-face interviews. A non-probability sample (n = 726) was frequency matched to national government estimates on age, level of education, and gender. The study was approved by the ethical committee of the University Hospital of Brussels.

Setting and Participants

Sampling took place in the Beirut and Mount-Lebanon, 2 governorates that together host half of the Lebanese population. Sampling stations included places with varying socio-economic characteristics such as gyms, medium size malls, community-based pharmacies, churches, mosques, tea houses, and public markets. Recruitment took place after obtaining permission and support from municipal authorities and people in charge of the sampling location, on any day of the week and at different times of the day. During recruitment, an interviewer would approach people in the sampling station and provide information about the study (see section on ethical considerations). Inclusion criteria were having the Lebanese nationality and being adult (defined as ≥20 years old to allow distribution comparison between sample and government data). Exclusion criteria were severe hearing or speaking difficulties. All refusals were registered. No financial incentives were provided.

Instrument

The questionnaire was based on two existing validated English language measures of cancer awareness (the UK Cancer Awareness Measure and the US Health Information National Trends Survey).^17,18 We performed forward and backward translation to Modern Standard Arabic and made some adaptations to include culturally specific elements such as use of waterpipe, which has been shown to be carcinogenic.¹⁹ The resulting questionnaire was pretested by performing in-depth interviews with 5 persons, after which appropriate clarifications were made.²⁰

The questionnaire included questions on knowledge and beliefs of cancer risk factors, personal behavior regarding risk factors, knowledge and beliefs of early cancer symptoms, barriers to seeking timely care, and sociodemographic characteristics (age, gender, employment, marital status, highest education).

Knowledge and beliefs of cancer risk factor was first evaluated in an open-ended recall question (what do you think are the biggest risk factors for developing cancer?). Next, we presented a recognition question with 24 factors for which we asked, “Do you think any of these can influence someone’s risk of developing cancer?” Among these 24 factors were 14 that the International Agency for Research on Cancer classified as carcinogenic, 7 that are classified as having no influence on cancer risk, and 3 that lower cancer risk (see Table 4).²¹

There were 8 answering options: I do not know; neither increases nor decreases, increases risk strongly/moderately/somewhat, decreases risk strongly/moderately/somewhat. All 3 “increase” options were counted as correct answers for the 14 carcinogens, the option “neither increases nor decreases” was counted as correct for the 7 factors that do not influence risk (we refer to these as neutral factors), the 3 “decrease” answer were counted as correct for the 3 protective factors.

Knowledge and beliefs of early cancer symptoms were evaluated in an open-ended recall question (Please name early warning signs of cancer, as many as you can think of). The authors from the UK Cancer Awareness Measure have previously categorized these signs into 2 groups: key cancer symptoms (lump, bleeding, changing bowel habits) and vague cancer symptoms (cough, weight loss, tiredness, loss of appetite), and we used the same categorization.

Lifestyle behavior questions were close-ended questions that enquired about the amount of daily exercise, consumption of waterpipe, cigarettes, and alcohol.

Barriers to seeking timely care were assessed in close-ended questions in which we presented 10 statements and asked, “Would any of the following keep you from seeking medical care?” (5-point Likert scale answers).

Sample Size

Epi-info was used to calculate the required sample size, using the following equation

n = \frac{{(Z_{1 - α / 2})}^{2} p (1 - p)}{d^{2}}

where Z is a standard normal variate (Z1-α/2 = 1.96 at 95% confidence interval), d is the absolute accuracy or precision (5% marginal error), P is the expected proportion of the population with a specific outcome and was set at .5 (the advised value if the proportion in the population is not known). This yielded a necessary sample size of 385, which was doubled to allow for sub analyses by gender.

Statistical Analysis

Data were analyzed using Stata version 13 (StataCorp, USA). Answers to the open-ended questions on cancer risk factors and early cancer symptoms were categorized, and the proportion of each category was calculated against the total number of participants. For the 24 closed-ended risk factor recognition questions, the proportion of people that recognized a factor correctly was calculated against the total number of participants for each factor. The chi-square test was used to compare this proportion between men and women with significance set at P < .05. The arithmetic mean of the 24 factors was also calculated for the 14 carcinogens as a group, for the 7 neutral factors as a group, and for the 3 protective factors as a group.

Per lifestyle behavior (alcohol, physical exercise, waterpipe, and cigarettes), an ordered logistic regression was run in which the answers to the lifestyle behavior question were used for the dependent variable, and the answers to the risk perception question were used as independent variable, together with gender and age (two demographic variables which have previously been shown to be correlated to behavior). Significance was set at P < .05. In case a significant correlation was found, we tested the proportional odds assumption through a likelihood ratio test with the user-written command called omodel with significance set at P < .05.²²

For the 10 closed-ended recognition questions regarding barriers that keep adults from seeking timely care the answers “I agree completely” and “I agree somewhat” were grouped together, and the proportion of this sum was calculated against the total number of participants. The chi-square test was used to compare this proportion between men and women with significance set at P < .05.

Ethical Considerations

Informed consent was sought from every participant by explaining the objectives of the study, that participation was voluntary, that anonymity of the participants was guaranteed and that withdrawal at any point was possible. The study was approved by the ethical committee of the University Hospital of Brussels with reference number CAL-3.1.

Results

Characteristics of Participants

Of the 861 people who were approached to participate in the study, 123 refused to participate (14.3%) and 738 completed the survey (85.7%) on the spot. Inclusion and exclusion criteria were met by 726 (98.5% of the completed surveys). Table 1 shows socio-demographic characteristics of the sample besides national data for 2009 (most recent data that were freely available by age-group which was needed to allow for accurate comparison of distribution). The distribution of gender, age, civil status, and education is similar between sample and general population, but the sample has a higher proportion of employed people (62.3% vs 48.7%).

Table 1.

Distribution of socio-demographic characteristics among participants and the general population.

	Respondents (age 20+)		Government estimate 2009* (age 20+)		P-Value
Lebanese nationals aged 20+, % (N)	100.0	(726)	100.0	(35 681)
Gender, % (N)					.890
Male	49.4	(359)	49.0	(17 476)
Female	50.6	(367)	51.0	(18 205)
Mean age in years (SD)	42.7	(15.8)
Age in years, % (N)					.082
20–29	26.0	(189)	26.0	(9289)
30–39	20.1	(146)	19.8	(7076)
40–49	20.2	(147)	19.9	(7115)
50–59	16.2	(118)	16.9	(6023)
60–69	12.0	(87)	9.6	(3413)
70+	5.4	(39)	7.7	(2765)
Civil status, % (N)					<.001
Never married	37.3	(264)	30.5	(10 892)
Married	47.8	(338)	62.0	(22 113)
Widowed	5.4	(38)	6.2	(2209)
Divorced	6.4	(45)	1.0	(3,74)
Separated	3.1	(22)	0.2	(73)
Missing	-	(19)	-	(20)
Work status, % (N)					<.001
Employed (including self-employed)	62.3	(444)	48.7	(17 376)
Unemployed	10.1	(72)	5.5	(1967)
Student	12.9	(92)	6.3	(2249)
Retired	2.0	(14)	2.8	(1011)
Inactive (occupied with housework..)	11.9	(85)	32.4	(11 555)
Unable to work for health reasons	0.8	(6)	4.2	(1516)
Missing	-	(13)	-	(7)
Highest level of education, % (N)					.491
Cannot read and write	10.1	(73)	10.2	(3596)
Can read and write, max. Kindergarten	5.1	(37)	3.6	(1281)
Elementary school	21.7	(157)	22.2	(7818)
Intermediate	23.8	(172)	23.9	(8419)
Secondary	16.9	(122)	17.1	(6030)
University	22.5	(163)	23.0	(8112)
Missing	—	(2)	—	(425)
Personal monthly income in USD**, % (N)
<500	22.9	(137)
500–999	34.8	(208)
1000–1499	29.1	(174)
>1500	13.2	(79)
Missing	—	(128)

* Estimates from the Central Administration of Statistics (based on sampling methodology, available from: http://www.cas.gov.lb, accessed on May 01, 2019) ** National data on income were not available.

Knowledge and Beliefs of Cancer Risk Factors

Table 2 shows the factors that Lebanese adults identified as carcinogens on spontaneous recall (open-ended). Two carcinogens were named far more often than any other: pollution (39.8%, N = 289) and smoking (34.8%, N = 253). Other factors in sequence of frequency: depression and stress (7.6%), a variety of foods (6.8%), UV-rays (6.3%), and genetics (2.1%). There were no significant differences between men and women.

Table 2.

Factors Lebanese adults recall as the most important causes of cancer (Lebanon, 2019).

Factor	Total	Males vs females
	(n = 726)	Males (n = 359)	Females (n = 367)	P-value
	n (%)	n (%)	n (%)	P-value
Pollution (air and/or water)	289 (39.8)	137 (38.2)	152 (41.4)	.37
Smoking cigarettes or waterpipe	253 (34.8)	133 (37.0)	120 (32.7)	.22
Depression or stress	55 (7.6)	31 (8.6)	24 (6.5)	.29
Particular food	49 (6.8)	23 (6.4)	26 (7.1)	.72
Sun and UV	46 (6.3)	21 (5.8)	25 (6.8)	.60
Genetics	15 (2.1)	5 (1.4)	10 (2.7)	.21
Other	16 (2.2)	6 (1.7)	10 (2.7)	.33

Table 3 shows the results of the recognition questions. On average, the carcinogens and protective factors were more often recognized than the neutral factors (correct recognition in, respectively, 75%, 75%, and 22% of the time). The carcinogens that were most often correctly identified were cigarette smoking, waterpipe smoking, and air pollution (97.5%, 96.6%, and 94.6%, respectively). The least recognized carcinogens were HPV-infection (32.6%) and sedentary lifestyle (48.6%). The protective factors were all correctly identified by the majority of people: physical exercise (83.2%), fruits and vegetables (73.7%), a diet high in fiber (69.3%). The neutral factors were rarely identified correctly and instead attributed carcinogenic properties. The lowest knowledge level was found for food coloring, tap water, poultry, and depression (6.7%, 16.1%, 19.8%, and 23.4%, respectively), all of which neither increase nor decrease the cancer risk.

Table 3.

Correct recognition of the role of lifestyle factors and aging in cancer risk (Lebanese adults, Lebanon, 2019).

Factor*	Total	Males vs females
	(n = 726)	Males (n = 359)	Females (n = 367)	P-value
	n (%)	n (%)	n (%)	P-value
(↑) Smoking cigarettes	708 (97.5)	349 (97.2)	359 (97.8)	.60
(↑) Smoking waterpipe	701 (96.6)	345 (96.1)	356 (97.0)	.51
(↑) Air pollution	687 (94.6)	341 (95.0)	346 (94.3)	.67
(↑) Second-hand smoke	660 (90.9)	330 (91.9)	330 (89.9)	.35
(↑) Processed meats	658 (90.6)	323 (90.0)	335 (91.3)	.54
(↑) Sun	636 (87.6)	307 (85.5)	329 (89.6)	.09
(↓) Physical exercise	604 (83.2)	290 (80.8)	314 (85.6)	.08
(↑) E-cigarettes	570 (78.5)	278 (77.4)	292 (79.6)	.48
(↓) Fruit and vegetables	535 (73.7)	254 (70.8)	281 (76.6)	.08
(↑) Being overweight	478 (65.8)	248 (69.1)	230 (62.7)	.07
(↓) Diet high in fiber	503 (69.3)	242 (67.4)	261 (71.1)	.28
(↑) Red meats	480 (66.1)	234 (65.2)	246 (67.0)	.60
(↑) Drinking hot liquid	460 (63.4)	223 (62.1)	237 (64.6)	.49
(↑) Alcohol	460 (63.4)	227 (63.2)	233 (63.5)	.94
(↑) Aging	451 (62.1)	229 (63.8)	222 (60.5)	.36
(↑) Sedentary lifestyle	353 (48.6)	186 (51.8)	167 (45.5)	.09
(↑) HPV-infection	237 (32.6)	119 (33.2)	118 (32.2)	.78
(−) Deodorant	220 (30.3)	122 (34.0)	98 (26.7)	.03
(−) Lack of sleep	212 (29.2)	114 (31.8)	98 (26.7)	.13
(−) Using mobile phone	211 (29.1)	106 (29.5)	105 (28.6)	.79
(−) Depression or anxiety	170 (23.4)	81 (22.6)	89 (24.2)	.59
(−) Poultry	144 (19.8)	81 (22.6)	63 (17.2)	.07
(−) Tap water	117 (16.1)	61 (17.0)	56 (15.3)	.53
(−) Food coloring	49 (6.7)	25 (7.0)	24 (6.5)	.82

(↑) indicates this factor is carcinogenic; (↓) indicates this factor protects against cancer; (−) indicates this factor neither increases nor decreases the cancer risk.

The only factor for which results differed significantly between men and women was deodorant. While 73.3% of women incorrectly attributed carcinogenic properties to deodorant, men did so less often (69.7%, P = .03).

Correlation Between Risk Factor Knowledge and Personal Behavior

Table 4 shows that each step of seeing waterpipe as more harmful was associated with a lower personal frequency of waterpipe use (OR up 5.51, P = .001). The same was found for alcohol (OR up to 3.66, P = .020) and the benefits of physical activity (OR up to 3.26, P = .008). No such correlation was found for cigarette smoking.

Table 4.

Correlation between knowledge and behavior. (Lebanese adults, Lebanon, 2019).

	N	OR*	P-value	(95% CI)
Waterpipe, odds ratio for less likely use
Perceived effect of waterpipe smoking
Decreases risk	0	—
Neither increases nor decreases	16	Ref
Somewhat increases	67	2.69	.077	(.90–8.06)
Moderately increases	174	2.62	.070	(.92–7.44)
Strongly increases	460	5.51	.001	(1.97–15.4)
Cigarettes, odds ratio for less likely use
Perceived effect of cigarette smoking
Decreases risk	0	—
Neither increases nor decreases	11	Ref
Somewhat increases	65	.82	.764	(.21–3.05)
Moderately increases	222	1.00	.997	(.28–3.51)
Strongly increases	421	1.14	.837	(.33–3.97)
Alcohol, odds ratio for less likely use
Perceived effect of alcohol consumption
Decreases risk	14	Ref
Neither increases nor decreases	225	3.04	.030	(1.12–8.29)
Somewhat increases	227	2.86	.039	(1.05–7.78)
Moderately increases	154	3.84	.010	(1.37–10.74)
Strongly increases	79	3.66	.020	(1.23–10.88)
Physical activity, odds ratio for higher activity
Perceived effect of physical activity
Increases risk	29	Ref
Neither increases nor decreases	79	2.32	.086	(.89–6.05)
Somewhat decreases	94	2.03	.140	(.79–5.19)
Moderately decreases	244	3.07	.013	(1.27–7.40)
Strongly decreases	266	3.26	.008	(1.36–7.83)

Knowledge and Beliefs of Early Cancer Symptoms

Table 5 shows that cancer warning signs were not well known: 10.6% could not think of any signs, 5.6% wrongfully believes cancer has no early warning signs, and 11.6% only names things that are not important early cancer warning signs (pale skin, nausea, dizziness, fainting, fever, hair loss). This amounts to 27.8% of participants that cannot name important early warning signs. Of the key cancer symptoms, the most frequently mentioned were a lump (27.3%), bleeding (8.8%) and new spots on the skin (6.5%). Of the vague signs the most frequently mentioned were unexplained tiredness (25.2%), unexplained pain (21.9%), unexplained weight loss (12.3%), a persistent cough (8.7%) and loss of appetite (5.0%). The only factor for which results differed significantly between men and women was unexplained weight loss, while 16.1% of women correctly saw this as an early cancer warning sign, men did so less often (8.4%, P = .002).

Table 5.

Early cancer symptoms Lebanese adults recall (Lebanon, 2019).

Factor	Total	Males vs females
	(n = 726)	Males (n = 359)	Females (n = 367)	P-value
	n (%)	n (%)	n (%)	P-value
Lump	198 (27.3)	93 (25.9)	105 (28.6)	.41
Unexplained tiredness	183 (25.2)	88 (24.5)	95 (25.9)	.67
Unexplained pain	159 (21.9)	69 (19.2)	90 (24.5)	.08
Unexplained weight loss	89 (12.3)	30 (8.4)	59 (16.1)	.002
Bleeding (stool, urine, undefined)	64 (8.8)	28 (7.8)	36 (9.8)	.34
Persistent cough	63 (8.7)	27 (7.5)	36 (9.8)	.27
Altered spots on skin	47 (6.5)	23 (6.4)	24 (6.5)	.94
Loss of appetite	36 (5.0)	22 (6.1)	14 (3.8)	.15
Swollen lymph nodes	36 (5.0)	13 (3.6)	23 (6.3)	.10
Weight gain	22 (3.0)	13 (3.6)	9 (2.4)	.36
Other early sign	24 (3.3)	16 (4.5)	8 (2.2)	.09
Answers only things that are not early cancer symptoms	84 (11.5)	42 (11.7)	42 (11.4)	.91
Answers (s)he does not know any early cancer signs	77 (10.6)	43 (12.0)	34 (9.3)	.24
Answers cancer has no early symptoms	41 (5.6)	21 (5.8)	20 (5.4)	.82

Barriers That Keep Knowledge of Early Cancer Symptoms From Turning Into Action

Table 6 shows that the most frequent barriers for not seeking timely care were financial (58.3%), fear of finding illness (55.0%), and having other things to worry about (42.7%). Issues with interaction at the physician’s office were much less common (being overheard, fear of wasting the physician’s time, difficulties communicating with physician).

Table 6.

Barriers to seeking timely care (Lebanese adults, Lebanon, 2019).

Factor	Total	Males vs females
	(n = 726)	Males (n = 359)	Females (n = 367)	P-value
	n (%)	n (%)	n (%)	P-value
I do not always have enough money to see my doctor	423 (58.3)	218 (60.7)	205 (55.9)	.18
I fear the doctor might find cancer	399 (55.0)	191 (53.2)	208 (56.7)	.35
I have too many other things to worry about	310 (42.7)	143 (39.8)	167 (45.5)	.12
I do not like that someone other than the doctor might hear my symptoms	302 (41.6)	143 (39.8)	159 (43.3)	.34
I would be worried the doctor would not take me seriously	290 (39.9)	137 (38.2)	153 (41.7)	.33
I would be too busy to make time to go to the doctor	232 (32.0)	117 (32.6)	115 (31.4)	.72
I find it difficult to get an appointment with the right doctor	225 (31.0)	109 (30.4)	116 (31.6)	.72
My doctor is difficult to talk to	159 (21.9)	72 (20.1)	87 (23.7)	.23
I would be worried about wasting the doctor’s time	137 (18.9)	65 (18.1)	72 (19.6)	.60
I find it embarrassing to talk to the doctor about my symptoms	113 (15.6)	59 (16.4)	54 (14.7)	.52

Discussion

Knowledge of Cancer Risk Factors and Correlation Between Knowledge and Behavior

Overall, it is comforting that smoking was identified as the prime lifestyle carcinogen in both recall and recognition questions and that many other carcinogens were also correctly recognized. Cigarettes and waterpipe were recognized as carcinogenic by over 95% of participants and were the most mentioned factor on recall, which is comparable to results in the UK.²³ The exceptions to high knowledge of carcinogens (less than 50% classified them as carcinogenic) were HPV (32.6%) and physical inactivity (48.6%). Previous research in Lebanon also found tobacco to be far more known as a carcinogen than other factors such as lack of exercise and being overweight.²⁴

The striking lack of knowledge about HPV confirms earlier research that found only 24.8%–34% of adults were aware of the cancer risks of HPV.^10,15 We only investigated knowledge of HPV itself, but future research should also look into knowledge of the HPV vaccine since HPV vaccination is an important aspect of primary prevention for HPV-related cancers and knowledge of this vaccine has previous been shown to be low.²⁴

The lack of knowledge about the risk of a sedentary lifestyle (48.6%) confirms earlier research that found that only 36.5% of adults see it as a risk factor for colorectal cancer.¹¹

Alcohol and aging (respectively recognized as a carcinogen by 63.4% and 62.1%) were the other least known carcinogenic risks. This confirms previous research that found 52.8% of Lebanese identified alcohol as a risk factor for colorectal cancer and 25.4% see advanced age as a risk factor for cancer.¹¹

More worryingly, factors that do not influence cancer risk were incorrectly recognized as carcinogenic by a large percentage of people (food coloring: 93.7%; tap water: 83.9%; depression and anxiety: 76.6%). Similarly, non-carcinogenic factors were also mentioned as important causes of cancer in the recall question: depression and stress (7.6%) and a variety of foods (6.8%). Attributing a carcinogenic effect to a non-carcinogenic factor has been observed in other countries as well.²⁵ Social media may be at least partly responsible for spreading such cancer myths and can therefore also be used to counter the myths.²⁵

Higher knowledge of risk was moderately correlated with beneficial behavior for waterpipe, alcohol and physical activity, suggesting that a well-designed knowledge campaign could be effective to reduce exposure. Such a correlation was not detected for cigarette smoking, which confirms previous research that also found a large gap between knowledge and behavior.^26-28

Knowledge and Beliefs of Early Cancer Symptoms and Barriers That Keep Such Knowledge From Turning Into Action

Recall of key early warning signs was low in our study especially when compared to results of the UK. Our results are very similar to previous research on recall of early warning signs in Lebanon and can also be compared to recall results from the Gaza strip: (i) a lump was the most recalled symptom (27.3% in our study, 23.5% in previous Lebanese research, 59% in the UK, and 39.7% in the Gaza strip), followed by (ii) unexplained bleeding (8.8% in our study, 4.4% in previous Lebanese research, 35% in the UK, and 6.5% in the Gaza strip), and (iii) altered spots on skin (6.5% in our study, 2.2% in previous Lebanese research, and 18% in the UK).^15,23,29

Vague symptoms were also less known then in the UK, but very comparable to previous Lebanese research: (i) unexplained pain (21.9% in our study, 22.9% in previous Lebanese research, 34% in the UK, and 18.7% in the Gaza strip), (ii) persistent cough (8.7% in our study, 4.1% in previous Lebanese research, 24% in the UK, and 2.2% in the Gaza strip), and (iii) weight loss (12.3% in our study, 9.4% in previous Lebanese research, 26% in the UK, and 19.7% in the Gaza strip). Interestingly, there were two vague warning signs that were more known in our study than in the UK: loss of appetite (12.3% in our study vs 7% in the UK) and tiredness (25.2% in our study vs 16.0% in the UK).^15,23,29

The most often mentioned barrier to consulting a physician were of a financial nature (58.3%), fear of finding illness (55.0) and having many other things to worry about (42.7%). This confirms previous Lebanese research (respectively, 67.7%, 34.2%, and 28.2%).¹⁵

Possible Aspects of Future Strategies to Promote Primary Prevention and Early Diagnosis

Well-timed and evidence-led campaigns will be useful to raise knowledge about cancer risks, cancer myths, and cancer early warning signs, which will benefit any efforts to promote primary prevention and early diagnosis. Information material of the International Agency for Research on Cancer (www.euro.who.int, European Code against Cancer) and Cancer Research UK (https://www.cancerresearchuk.org/about-cancer/cancer-symptoms) could, for instance, be translated to the Lebanese dialect.

However, such campaigns need to be embedded in behavior change programs that also address other barriers to change. This is exemplified by our findings of a gap between knowledge and behavior and the existence of non-knowledge based barriers. Inspiration for such a multifaceted approach can be found in “Europe’s Beating Cancer Plan” or from previous research and include, for instance, (i) increasing taxes on tobacco, alcohol, and high-calorie foods; (ii) decreasing taxes on healthy choices such fruits and vegetables, bikes, and gyms; (iii) smoking bans; (iv) reducing young people’s exposure to online marketing and advertising of unhealthy food products such as alcohol and high-calorie food or drinks; (v) mandatory labeling of alcoholic beverages for ingredients, nutrient content, and health warnings; (vi) encouraging schools to eliminate sales of high-calorie drinks and snacks and instead promote the sales of fruits and vegetables on their premises; and (vii) working with celebrities through social media to deal with low knowledge levels.^30-32

Another important tool to lower cancer burden is screening (screening means to diagnose cancer before symptoms are present, as opposed to early diagnosis which means diagnosis is made when the first symptoms appear). Awareness campaigns have in the past succeeded in increasing breast cancer screening uptake, suggesting that future strategies to lower cancer burden should include raising awareness for cancer screening.³³ At the moment, national screening programs in Lebanon are limited to breast cancer. Although assessing the level of knowledge of participants regarding screening was out of scope of the current study, previous research revealed significant knowledge gaps regarding screening and that knowledge about breast cancer screening was among higher than for other types of screening.²⁴

Strengths and Limitations

Our study had some major strengths. We based our questionnaire on a validated measure of cancer knowledge and beliefs, managed to reach the lower socio-economical groups, had less than 15% of refusals to participate, and had very few missing data (except for the variable personal income). Our population-based sample was also frequency matched to important demographic variables. Although this method is inferior to a random sampling design, it is more likely to give representative results compared to a non-random sampling method that neither checks nor adjusts for population distribution. However, our study also has limitations. Recall and recognition are different methods of measuring cancer knowledge and beliefs; recall is thought to underestimate knowledge and beliefs, while recognition is thought to overestimate it.³⁴ Of the eight Lebanese governorates, our sample strategy included only two (mainly urban). Therefore, it cannot be guaranteed that our results are generalizable to Lebanon as a whole, although our sample was matched to national data on socio-economic variables. It would also have been interesting to also address the level of knowledge of participants regarding screening for cancer. Although this was out of scope of the current study, we recommend pursuing this topic in future research since screening is an important tool in lowering cancer burden.

Conclusion

This study revealed important knowledge gaps which are likely to hamper primary prevention and early diagnosis. Well-timed and evidence-led campaigns are needed to raise knowledge about cancer risks, cancer myths, and cancer early warning signs. However, we also provided two reasons why future information campaigns need to be embedded in behavior change programs that also address other barriers to change: (i) high knowledge of risk was not always correlated with low-risk behavior and (ii) we found barriers which keep people from seeking timely health care but which have nothing to do with a lack of knowledge.

Footnotes

Acknowledgments

The authors would like to thank Jon Shelton, Briony Hudson, Brigitta Boonen, and Sacha Hatem for their valuable contributions.

Authors’ contributions

Georges Hatem, Diana Ghanem, Ibrahim AlZaim, Eliane Kellen, and Mathijs Goossens contributed to the design of this study, the analysis of its data and the writing of the article. All authors reviewed the final version of the submitted article and approved it for publication. Georges Hatem, Diana Ghanem, and Ibrahim AlZaim oversaw data collection. Georges Hatem prepared the tables together with Mathijs Goossens.

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

Ethical Approval

This study was approved by the ethical committee of the University Hospital of Brussels with reference number CAL-3.1. All procedures performed involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was sought from every participant by explaining the objectives of the study that participation was voluntary, that anonymity of the participants was guaranteed, and that withdrawal at any point was possible.

ORCID iDs

Georges Hatem

Data Availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

Kulhánová

Bray

Fadhil

, et al. Profile of cancer in the Eastern Mediterranean region: the need for action. Cancer Epidemiol. 2017;47:125-132.

Globocan 2020: Lebanon Fact Sheets. Available from. https://gco.iarc.fr/today/data/factsheets/populations/422-lebanon-fact-sheets.pdf. accessed on 01/04/2021.

Rahim

Sibai

Khader

, et al. Non-communicable diseases in the Arab world. Lancet. 2014;383:356-367.

World Health Organization . Cancer Control: Knowledge into Action WHO Guide for Effective Programs: Early Detection. Geneva: WHO; 2007.

Kulhánová

Znaor

Shield

, et al. Proportion of cancers attributable to major lifestyle and environmental risk factors in the Eastern Mediterranean region. Int J Cancer. 2020;146:646-656.

Naja

Nasreddine

Awada

El Sayed Ahmad

Hwalla

. Nutrition in the prevention of breast cancer: a middle eastern perspective. Front Public Health. 2019;7:316.

Charafeddine

Olson

Mukherji

, et al. Proportion of cancer in a Middle eastern country attributable to established risk factors. BMC Cancer. 2017;17:337.

Quaife

Forbes

LJL

Ramirez

, et al. Recognition of cancer warning signs and anticipated delay in help-seeking in a population sample of adults in the UK. Br J Cancer. 2014;110(1):12-18.

Musaiger

Al-Hazzaa

Takruri

Mokhatar

. Change in Nutrition and Lifestyle in the Eastern Mediterranean Region: Health Impact. Journal of Nutrition and Metabolism. 2012;2012:1-2.

10.

Abou El Ola

Rajab

Abdallah

, et al. Low rate of human papillomavirus vaccination among schoolgirls in Lebanon: barriers to vaccination with a focus on mothers’ knowledge about available vaccines. Therapeut Clin Risk Manag. 2018;14:617-626.

11.

Tfaily

Naamani

Kassir

, et al. Knowledge of colorectal cancer and attitudes towards its screening guidelines in Lebanon. Ann Glob Health. 2019;85:75.

12.

Mallat

Geagea

Jurjus

, et al. Obesity in Lebanon: a national problem. World J Cardiovasc Dis. 2016;6:166-174.

13.

Souaid

Hindy

J-R

Eid

Kourie

Kattan

. Bladder cancer knowledge in the Lebanese population: when ignorance could be harmful. Bull Cancer. 2018;105:857-861.

14.

WHO . Barriers to early cancer diagnosis and treatment. Available from. https://www.euro.who.int/en/health-topics/noncommunicable-diseases/cancer/policy/screening-and-early-detection/barriers-to-early-cancer-diagnosis-and-treatment#:∼:text=These%20include%20poor%20cancer%20knowledge,in%20diagnosis%2C%20administrative%20red%20tape%2C. accessed on 01/04/2020.

15.

Alawa

Hamade

Alayleh

Fayad

Khoshnood

. Cancer awareness and barriers to medical treatment among Syrian refugees and Lebanese citizens in Lebanon. J Cancer Educ. 2020;35:709-717.

16.

Bou-Orm

Sakr

Adib

. Cervical cancer screening among Lebanese women. Rev Epidemiol Sante Publique. 2018;66:1-6.

17.

Stubbings

Robb

Waller

, et al. Development of a measurement tool to assess public knowledge of cancer. Br J Cancer. 2009;101:S13-S17.

18.

Nelson

Kreps

Hesse

, et al. The Health Information National Trends Survey (HINTS): development, design, and dissemination. J Health Commun. 2004;9:443-460.

19.

Akl

Gaddam

Gunukula

Honeine

Jaoude

Irani

. The effects of waterpipe tobacco smoking on health outcomes: a systematic review. Int J Epidemiol. 2010;39:834-857.

20.

Buschle

Reiter

Bethmann

. The qualitative pretest interview for questionnaire development: outline of programme and practice. Qual Quantity. 2021;4:1-20.

21.

Schuz

Espina

Villain

, et al. European Code against Cancer 4th Edition: 12 ways to reduce your cancer risk. Cancer Epidemiology. 2015;39:S1-S10.

22.

University of California . Ordered logistic regression. Available from. https://stats.idre.ucla.edu/stata/dae/ordered-logistic-regression/https://stats.idre.ucla.edu/stata/dae/ordered-logistic-regression/. accessed on 01/05/2020.

23.

Connor

Hudson

Power

. Knowledge of the signs, symptoms, and risk factors of cancer and the barriers to seeking help in the UK: comparison of survey data collected online and face-to-face. Jmir Cancer. 2020;6:e14539.

24.

Telvizian

Al Ghadban

Alawa

, et al. Knowledge, beliefs, and practices related to cancer screening and prevention in Lebanon: community and social media users’ perspectives. Eur J Cancer Prev. 2021;30:341-349.

25.

Shahab

McGowan

Waller

Smith

. Prevalence of beliefs about actual and mythical causes of cancer and their association with socio-demographic and health-related characteristics: findings from a cross-sectional survey in England. Eur J Cancer. 2018;103:308-316.

26.

National Research Council (US) . Panel on Race, Ethnicity, and Health in Later Life. In: Anderson

Bulatao

Cohen

, eds. Critical Perspectives on Racial and Ethnic Differences in Health in Late Life. Behavioural Health Interventions: What Works and Why? Washington: National Academies Press; 2004.

27.

Haddad

Lahoud

Akel

, et al. Knowledge, attitudes, harm perception, and practice related to waterpipe smoking in Lebanon. Environ Sci Pollut Control Ser. 2020;27:17854-17863.

28.

Bowen

Alfano

McGregor

Robyn Andersen

. The relationship between perceived risk, affect, and health behaviours. Cancer Detect Prev. 2004;28:409-417.

29.

Elshami

Alshorbassi

, et al. Knowledge level of cancer symptoms and risk factors in the Gaza Strip: a crosssectional study. BMC Publ Health. 2020;20:414.

30.

European Commission . Europe’s Beating Cancer Plan. European Commission; 2021. Available from. https://ec.europa.eu/health/sites/default/files/non_communicable_diseases/docs/eu_cancer-plan_en.pdf. accessed on 01/04/2021.

31.

Randolph

Whitaker

Arellano

. The unique effects of environmental strategies in health promotion campaigns: A review. Eval Progr Plann. 2012;35:344-353.

32.

Casey

Morris

Burnell

Parberry

Singh

Rosenthal

. Celebrities and screening: a measurable impact on high-grade cervical neoplasia diagnosis from the ‘Jade Goody effect’ in the UK. Br J Cancer. 2013;109:1192-1197.

33.

Adib

Sabbah

Hlais

Hanna

. Research in action: mammography utilization following breast cancer awareness campaigns in Lebanon 2002-05. East Mediterr Health J. 2009;15:6-18.

34.

Robb

Stubbings

Ramirez

, et al. Public knowledge of cancer in Britain: a population-based survey of adults. Br J Cancer. 2009;101:S18-S23.

Knowledge and Beliefs of Cancer Risk Factors and Early Cancer Symptoms in Lebanon: A Cross-sectional Survey Among Adults in the Community

Abstract

Background

Methods

Results

Conclusion

Keywords

Background

Primary Prevention

Screening and Early Diagnosis

Aim

Materials and Methods

Setting and Participants

Instrument

Sample Size

Statistical Analysis

Ethical Considerations

Results

Characteristics of Participants

Knowledge and Beliefs of Cancer Risk Factors

Correlation Between Risk Factor Knowledge and Personal Behavior

Knowledge and Beliefs of Early Cancer Symptoms

Barriers That Keep Knowledge of Early Cancer Symptoms From Turning Into Action

Discussion

Knowledge of Cancer Risk Factors and Correlation Between Knowledge and Behavior

Knowledge and Beliefs of Early Cancer Symptoms and Barriers That Keep Such Knowledge From Turning Into Action

Possible Aspects of Future Strategies to Promote Primary Prevention and Early Diagnosis

Strengths and Limitations

Conclusion

Footnotes

Acknowledgments

Authors’ contributions

Declaration of Conflicting Interests

Funding

Ethical Approval

ORCID iDs

Data Availability

References