A mucinous cystic neoplasm of indeterminate malignant potential was found to have a well-circumscribed, 3.1 cm pseudosarcomatous mural nodule, similar to those previously described in the ovary. The nodule contained reactive giant cells and intermediate to large-sized tumor cells with bizarre mitotic figures and nuclear atypia. The tumor cells were found to be of non-epithelial origin, based on multiple negative stains for cytokeratins and ultrastructural demonstration of osteoclastic and osteoblastic differentiation and absent desmosomes. This case report is the only description of a pseudosarcomatous mural nodule in a mucinous cystic neoplasm with non-epithelial origins.
1. Prat J, Scully R. Ovarian mucinous tumors with sarcoma-like mural nodules, a report of seven cases. Cancer44:1332-1344, 1979
2.
2. Hamada T, Sasaguri T, Tanimoto A, Arima N, Nakano R, Miyayama H, Sasaguri Y. Ovarian mucinous cystadenocarcinoma with sarcoma-like mural nodules. J Surg Oncol58:201-207, 1995
3.
3. Czernobilsky B, Dgani R, Roth L. Ovarian mucinous cystadenocarcinoma with mural nodules of carcinomatous derivation: A light and electron microscopic study. Cancer51:141-148, 1983
4.
4. Prat J, Scully RE. Sarcomas in ovarian mucinous tumors, a report of two cases. Cancer44:1327-1331, 1979
5.
5. Marinho A, Nogueira R, Schmitt F, Sogrinho-Simoes M. Pancreatic mucinous cystadenocarcinoma with a mural nodule of anaplastic carcinoma. Histopathology26:284-287, 1995
6.
6. Posen JA. Giant cell tumor of the pancreas of the osteoclastic type associated with a mucous secreting cystadenocarcinoma. Hum Pathol12:944-947, 1981
7.
7. Bergman S, Medeiros LJ, Radr T, Mangham DC, Lewandrowski KB. Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma. Int J Pancreatol18:71-75, 1995
9. Tsujimura T, Kawano K, Taniguchi M, Yoshikawa K, Tsukaguchi I. Malignant fibrous histiocytoma coexistent with mucinous cystadenoma of the pancreas. Cancer70:2792-2796, 1992
10.
10. Rosai J. Carcinoma of pancreas simulating giant cell tumor of bone, electron-microscopic evidence of its acinar cell origin. Cancer22:333-344, 1968
11.
12. Trepeta RW, Mathur S, Lagin S, LiVolsi VA. Giant cell tumor (‘osteoclastoma’) of the pancreas; a tumor of epithelial origin. Cancer48:2022-2028, 1981
12.
13. Kay S, Harrison JM. Unusual pleomorphic carcinoma of the pancreas featuring production of osteoid. Cancer23:1158-1162, 1969
13.
14. Jeffrey I, Crow J, Ellis BW. Osteoclast-type giant cell tumor of the pancreas. J Clin Pathol36:1165-1170, 1983
14.
15. Jalloh SS. Giant cell tumor (osteoclastoma) of the pancreasan epithelial tumor probably of pancreatic acinar origin. J Clin Pathol36:1171-1175, 1983
15.
16. Alguacil-garcia A, Weiland LH. The histologic spectrum, prognosis, and histogenesis of the sarcomatoid carcinoma of the pancreas. Cancer39:1181-1189, 1977
16.
17. Ros PR, Hamrick-Turner JE, Chiechi MV, Ros LH, Gallego P, Burton SS. Cystic masses of the pancreas. Radiographics12:673-686, 1992
