Unusual Endobronchial Pulmonary Epithelioid Hemangioendothelioma

Abstract

A case of an unusual pulmonary epithelioid hemangioendothelioma is described in which two distinctive types of histologic lesion were combined. The patient was a 54-year-old man with persistent hemoptysis. The main lesion was an endobronchial tumor that had classic features of epithelioid hemangioendothelioma of soft tissue. Multiple peripheral parenchymal nodules resembled features of intravascular bronchioloalveolar tumor of the lung. The endothelial origin of the tumor cells was evident on both ultrastructural and immunohistochemical findings, including the presence of Weibel-Palade bodies and positive immunostaining to Ulex lectin and factor VIII-related antigen. This case seems to be an example with mixture of endobronchial epitheloid hemangioendothelioma of soft tissue type and peripheral intravascular bronchioloalveolar tumor histology, an association that has not been reported as yet. Int J Surg Pathol 3(1):59-64, 1995