Lymphomas associated with breast implants are rare, and the majority of these are anaplastic large-cell lymphomas of T-cell origin. Very uncommonly B-cell lymphomas associated with implants have been described, and examples of invasive disease are even less commonly reported. This report discusses one such 72-year-old patient who presented with pain and concerns about implant rupture on imaging. Histopathology demonstrated an invasive EBV + large B-cell lymphoma associated with bilateral silicone implants inserted 20 years previously. This was managed with implant explantation, capsulectomy and adjuvant chemotherapy.
CheahCYCampbellBASeymourJF. Primary breast lymphoma. Cancer Treat Rev.2014;40(8):900-908.
2.
NichterLSMuellerMABurnsRGStallmanJM. First report of nodal marginal zone B-cell lymphoma associated with breast implants. Plast Reconstr Surg.2012;129(3):576e-578e.
3.
SmithBKGraySS. Large B-cell lymphoma occurring in a breast implant capsule. Plast Reconstr Surg.2014;134(3):670e-671e.
4.
EvansMGMirandaRNYoungPA, et al.B-cell lymphomas associated with breast implants: report of three cases and review of the literature. Ann Diagn Pathol.2020;46:151512.
5.
KhooCMcTigueCHunter-SmithDJWalkerP. EBV Positive fibrin/chronic inflammation associated diffuse large B-cell lymphoma: an incidental finding associated with a breast implant. Pathology. 2021;53(6):673-675.
6.
MalataCMMadada-NyakauruRNFollowsGWrightP. Epstein–Barr virus-associated diffuse large B-cell lymphoma identified in a breast implant capsule: a new breast implant-associated lymphoma?Ann Plast Surg.2021;86(4):383-386.
7.
Rodriguez-PinillaSMGarciaFJSBalagueORodriguez-JustoMPirisMA. Breast implant-associated Epstein–Barr virus-positive large B-cell lymphomas: a report of three cases. Haematologica. 2020;105(9):e412-e414.
8.
MescamLCamusVSchianoJM, et al.EBV+ diffuse large B-cell lymphoma associated with chronic inflammation expands the spectrum of breast implant-related lymphomas. Blood. 2020;135(7):516-526.
9.
MedeirosLJMarques-PiubelliMLSangiorgioVFI, et al.Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship. Mod Pathol. 2021;34(7):1404-1416.
10.
CookPDOsborneBMConnorRLStraussJF. Follicular lymphoma adjacent to foreign body granulomatous inflammation and fibrosis surrounding silicone breast prosthesis. Am J Surg Pathol. 1995;19(6):712-717.
11.
KraemerDMTonyHPGattenlohnerSMullerJG. Lymphoplasmacytic lymphoma in a patient with leaking silicone implant. Haematologica. 2003;88(1):30.
12.
MolingOPiccinATauberM, et al.Intravascular large B-cell lymphoma associated with silicone breast implant, HLA-DRB111:01, and HLA-DQB103:01 manifesting as macrophage activation syndrome and with severe neurological symptoms: a case report. J Med Case Rep. 2016;10(1):254.
13.
GeethakumariPRMarkantonisJShahJL,et al.Breast implant-associated plasmablastic lymphoma: a case report and discussion of the literature. Clin Lymphoma Myeloma Leuk. 2019;19(10):e568-e572.
14.
ChenVWHoangDClancyS. Breast implant-associated bilateral B-cell lymphoma. Aesthet Surg J. 2020;40(10):NP52-NP58. doi: https://doi.org/10.1093/asj/sjz331
15.
BletsisPPJanssenLEVisserO,et al.Bilateral breast implant associated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): a case report. Int J Surg Case Rep. 2020;71:341-345.
16.
McCarthyCMLoyo-BerríosNQureshiAA, et al.Patient registry and outcomes for breast implants and anaplastic large cell lymphoma etiology and epidemiology (PROFILE): initial report of findings, 2012-2018. Plast Reconstr Surg.2019;143(3S):65S-73S.
17.
Loch-WilkinsonABeathKJKnightRJW, et al.Breast implant-associated anaplastic large cell lymphoma in Australia and New Zealand: high-surface-area textured implants are associated with increased risk. Plast Reconstr Surg.2017;140(4):645-654.
18.
MorganSTremblay-LeMayRLipaJE,et al.Breast implant-associated EBV-positive diffuse large B-cell lymphoma: two case reports and literature review. Pathol Res Pract.2021;226:153589.
19.
Copie-BergmanCNiedobitekGManghamDC, et al.Epstein-Barr virus in B-cell lymphomas associated with chronic suppurative inflammation. J Pathol.1997;183(3):287-292.
20.
CheukWChanACChanJKLauGTChanVNYiuHH. Metallic implant-associated lymphoma: a distinct subgroup of large B-cell lymphoma related to pyothorax-associated lymphoma?Am J Surg Pathol.2005;29(6):832-836.
