Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.
MerrimenJLEvansAJSrigleyJR.Preneoplasia in the prostate gland with emphasis on high grade prostatic intraepithelial neoplasia. Pathology. 2013;45:251-263.
3.
GuoCCEpsteinJI.Intraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance. Mod Pathol. 2006;19:1528-1535.
4.
ReyesAOSwansonPECarboneJMHumphreyPA.Unusual histologic types of high-grade prostatic intraepithelial neoplasia. Am J Surg Pathol. 1997;21:1215-1222.
5.
BostwickDGBrawerMK.Prostatic intra-epithelial neoplasia and early invasion in prostate cancer. Cancer. 1987;59:788-794.
6.
EpsteinJIGrignonDJHumphreyPA. Interobserver reproducibility in the diagnosis of prostatic intraepithelial neoplasia. Am J Surg Pathol. 1995;19:873-886.
7.
MontironiRMazzucchelliRAlgabaFLopez-BeltranA.Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance. J Clin Pathol. 2000;53:655-665.
8.
ChengLPatersonRFBeckSDParksJ.Prostatic intraepithelial neoplasia: an update. Clin Prostate Cancer. 2004;3:26-30.
9.
MontironiRMazzucchelliRLopez-BeltranAScarpelliMChengL.Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance. BJU Int. 2011;108:1394-1401.
10.
CalvoAXiaoNKangJ. Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. Cancer Res. 2002;62:5325-5335.
11.
TsuzukiT.Intraductal carcinoma of the prostate: a comprehensive and updated review. Int J Urol. 2015;22:140-145.
12.
WobkerSEEpsteinJI.Differential diagnosis of intraductal lesions of the prostate. Am J Surg Pathol. 2016;40:e67-e82.
13.
RobertsJAZhouMParkYWRoJY.Intraductal carcinoma of prostate: a comprehensive and concise review. Korean J Pathol. 2013;47:307-315.
14.
GiltmanLI.Signet ring adenocarcinoma of the prostate. J Urol. 1981;126:134-135.
15.
TorbensonMDhirRNangiaABecichMJKapadiaSB.Prostatic carcinoma with signet ring cells: a clinicopathologic and immunohistochemical analysis of 12 cases, with review of the literature. Mod Pathol. 1998;11:552-559.
16.
WarnerJNNakamuraLYPacelliAHumphreysMRCastleEP.Primary signet ring cell carcinoma of the prostate. Mayo Clin Proc. 2010;85:1130-1136.
17.
FujitaKSugaoHGotohTYokomizoSItohY.Primary signet ring cell carcinoma of the prostate: report and review of 42 cases. Int J Urol. 2004;11:178-181.
