Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, but they have been rarely reported in the esophagus. The authors present the case of an esophageal GIST and discuss the diagnostic course and therapeutic options, as currently reported in the literature.
Miettinen M. , Lasota J.Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. PolJ Pathol.2003; 54:3-24.
2.
Fletcher Cdm , Berman JJ, Corless C., et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol.2002;33:459-465.
3.
Wisecarver JLGetting to the GIST of it. Am J Gastroenterol.2001;96:644-645.
4.
Kindblom LG, Remotti HE, Aldenborg F., et al. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol.1998;152:1259-1269.
5.
Sircar K., Hewlett BR, Huizinga JD, et al. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol. 1999;23:377-389.
6.
Miettinen M. , Sarlomo-Rikala M., Lasota J.GISTs: recent advances in understanding of their biology. Hum Pathol.1999;30:1213-1220.
7.
Stadler J., Orda R., Baratz M., et al. Giant leiomyoma of the esophagus as a cause for gastrointestinal bleeding. J Clin Gastroenterol.1987;9:613-615.
8.
Chang WC, Tzao C., Shen DH, et al. Gastrointestinal stromal tumor (GIST) of the esophagus detected by positron emission tomography/computed tomography. Dig Dis Sci.2005;50:1315-1317.
9.
Bedard EL, Mamazza J., Schlachta CM, et al. Laparoscopic resection of gastrointestinal stromal tumors. Surg Endosc. 2006;20:500-503.
10.
Ertem M., Baca B., Dogusoy G., et al. Thoracoscopic enucleation of a giant submucosal tumor of the esophagus. Surg Laparosc Endosc Percutan Tech. 2004;14:87-90.
11.
Emory TS, Sobin LH, Lukes L., et al. Prognosis of GISTs: dependence on anatomic site. Am J Surg.1999;23:82.
Logrono R., Jones DV, Faruqi S., et al. Recent advances in cell biology, diagnosis and therapy of gastrointestinal stromal tumors (GIST). Cancer Biol Ther. 2004 ;3:251-258.
14.
Heinrich MC , Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies . J Clin Oncol.2002;20;1692-1703.
15.
DeMatteo RP , Heinrich MC, El-Rifai WM, et al. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Hum Pathol.2002;33:466-477.