Calcifying fibrous pseudotumor (CFP) has been postulated to be a “late” stage of inlammatory myofibroblastic tumor (IMT). We analyzed 15 cases (8 females and 7 males; aged 1 to 65 years). The anatomic distribution was wide, including 3 cases each in neck, mesentery/omentum, and GI tract and 2 cases each in mediastinum and paratesticular sites. Follow-up information was available in 1O patients (range 4 to 228 months). Local recurrence occurred in 3 patients and was repeated in 2. Tuor size ranged from 0.6 to 25 cm. Lesions were well-circumscribed hypocellular spindle cell proliferations with dense stromal collagen, a lymphoplasmacytic infilrate, and stromal calcifications. Features of conventional IMT were not seen. Imunostaining showed CD34 positivity in most cases as well as rare cells positive for smooth muscle actin and desmin, and consistent negativity for ALK-1 and S-100 proein. These findings suggest that CFP is a distinctive benign mesenchymal neoplasm with a low risk for recurrence and, therefore, best labelled as “calcifying fibrous tuor.” There is no convincing evidence to support an association between CFP and IMT.
1. Rosenthal NS, Abdul-Karim FW. Childhood fibrous tumor with psammoma bodies. Clinicopathologic features in two cases. Arch Pathol Lab Med112:798-800, 1988
2.
2. Fetsch JF, Montgomery EA, Meis JM. Calcifying firous pseudotumor. Am J Surg Pathol17:502-508, 1993
3.
3. Van Dorpe J, Ectors N, Geboes K, D'Hoore A, Sciot R. Is calcifying fibrous pseudotumor a late sclerosing stage of inflammatory myofibroblastic tumor?Am J Surg Pathol23:329-335, 1999
4.
4. Coffin CM, Watterson J, Priest JR, Dehner LP. Extraulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol19:859-872, 1995
5.
5. Fletcher CDM. Soft tissue tumors. In Diagnostic Histopathology of Tumors, 2nd ed.Churchill Livngstone, London, UK, pp. 1473-1540, 2000
6.
6. Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingam T, Perlman EJ. Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res59:2776-2780, 1999
7.
7. Maeda T, Hirose T, Furuya K, Kameoka K. Calcifying fibrous pseudotumor: An ultrastructural study. Ulrastruct Pathol23:189-192, 1999
8.
8. Hoffman H, Beaver ME, Maillard AAJ. Calcifying firous pseudotumor of the neck. Arch Pathol Lab Med124:435-437, 2000
10. Beleggia F, Beccia E, Morcaldi M, Fiorentino F, Casillo A, Sperandeo G, Mastidoro MR, Barbini VR. Aspetti ecografici dello pseudotumore fibroso calcificante dell'epididimo. Arch It Urol66:53-55, 1994
11.
11. Orui H, Yamakawa M, Ishikawa A, Ogino T. Calcifyng fibrous pseudotumor. A case report. J Bone Joint Surg80A:555-560, 1998
12.
12. Zamecnik M, Dorociak F, Vesely. Calcifying fibrous pseudotumor after trauma. Pathol Int47:812-812, 1997
13.
13. Jeong HS, Lee GK, Sung R, Ahn JH, Song HG. Calciying fibrous pseudotumor of mediastinum. A case report. J Korean Med Soc12:58-62, 1997
14.
14. Dumont P, de Muret A, Skrobala D, Robin P, Toumieux B. Calcifying fibrous pseudotumor of the mediastinum. Ann Thorac Surg63:543-544, 1997
15.
15. Fukunaga M, Kikuchi Y, Endo Y, Ushigome S. Calciying fibrous pseudotumor. Pathol Int47:60-63, 1997
16.
16. Hainaut P, Lesage V, Weynand B, Coche E, Noirhomme P. Calcifying fibrous pseudotumor (CFPT): A patient presenting with multiple pleural lesions. Acta Clin Belg54:162-164, 1999
17.
17. Hill KA, Gonzalez-Crussi F, Omeroglu A, Chou PM. Calcifying fibrous pseudotumor involving the neck of a five-week-old infant. Presence of factor XIIIa in the lesional cells. Pathol Res Pract196:527-531, 2000
18.
18. Kettani S, Francois H, Pidhorz L, Bertrand G. Pseudoumeur fibreuse calcifiante. Ann Pathol14:124-126, 1994
19.
19. Reed MK, Margraf LR, Nikaidoh H, Cleveland DC. Calcifying fibrous pseudotumor of the chest wall. Ann Thorac Surg62:873-874, 1996
20.
20. Pinkard NB, Wilson RW, Lawless N, Dodd LG, McAdams HP, Koss MN, Travis WD. Calcifying firous pseudotumor of pleura. A report of three cases of a newly described entity involving the pleura. Am J Clin Pathol105:189-194, 1996
21.
21. Ben-Izhak O, Itin L, Feuchtwanger Z, Lifschitz-Merer B, Czernobilsky B. Calcifying fibrous pseudotuor of mesentery presenting with acute peritonitis. Case report with immunohistochemical study and review of literature. Int J Surg Pathol9:249-253, 2001
22.
22. Sigel JE, Smith TA, Reith JD, Goldblum JR. Immunoistochemical analysis of anaplastic lymphoma kiase expression in deep soft tissue calcifying fibrous pseudotumor: Evidence of a late sclerosing stage of inflammatory myofibroblastic tumor?Ann Diagn Pathol5:10-14, 2001
23.
23. Hill KA, Gonzalez-Crussi F, Chou PM. Calcifying firous pseudotumor versus inflammatory myofiroblastic tumor: A histological and immunohistohemical comparison. Mod Pathol14:784-790, 2001
24.
24. Weynand B, Draguet AP, Bernard P, Marbaix E, Galant C. Calcifying fibrous pseudotumor: First case report in the peritoneum with immunostainng for CD34. Histopathology34:86-87, 1999
25.
25. Kocova L, Michal M, Sulc M, Zamecnik M. Calcifying fibrous pseudotumor of visceral peritoneum. Histopathology31:182-184, 1997
26.
26. Pomplun S, Goldstraw P, Davies SE, Burke MM, Nicholson AG. Calcifying fibrous pseudotumour arising within an inflammatory pseudotumour: Evdence of progression from one lesion to the other?Histopathology37:380-382, 2000
27.
27. Coffin CM, Patel A, Perkins S, Elenitoba-Johnson KS, Perlman E, Griffin CA. ALKI and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor. Mod Pathol14:569-576, 2001
28.
28. Cook JR, Dehner LP, Collins MH, Ma Z, Morris SW, Coffin CM, Hill DA. Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibrobastic tumor. A comparative immunohistochemical study. Am J Surg Pathol25:1364-1371, 2001
29.
29. Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CDM, Fletcher JA. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol157:377-384, 2000
30.
30. Bridge JA, Kanamori M, Ma Z, Pickering D, Hill DA, Lydiatt W, Lui MY, Colleoni GW, Antonescu CR, Ladanyi M, Morris SW. Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammaory myofibroblastic tumor. Am J Pathol159: 411-415, 2001
31.
31. Ladanyi M. Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. Am J Pathol157:341-345, 2000
32.
32. Goodlad JR, Fletcher CDM. Solitary fibrous tumors arising in unusual sites: Analysis of a series. Histopathology19:515-522, 1991
33.
33. Kilpatrick SE, Mentzel T, Fletcher CDM. Leiomyoma of deep soft tissue. Clinicopathologic analysis of a series. Am J Surg Pathol18:567-582, 1994
