Heparin Inhalation for Asthma

National Asthma Education Program Expert Panel Report. Guidelines for the diagnosis and management of asthma. J Allergy Clin Immunol 1991;88(3 pt 2):425-534.

Page CP. Are mast cells all bad? Postgrad Med J 1991;67(suppl 4):S6–12.

Lasser EC , Simon RA , Lyon SG , Hamblin AE , Stein R. Heparin-like anticoagulants in asthma. Allergy 1987;42:42-619.

Lasser EC , Lang JH , Curd JG , Cochrane CG , Lyon SG , Howard MM . The plasma contact system in atopic asthma. J Allergy Clin Immunol 1983;72:72-83.

Robinson C , Holgate ST. Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. Clin Sci 1985;68:68-103.

Bowler SD , Smith SM , Laverombe PS. Heparin inhibits the immediate response to antigen in the skin and lungs of allergic subjects. Am Rev Respir Dis 1993;147:147-160.

Ahmed T , Abraham WM , D'Brot J. Effects of inhaled heparin on immunologic and nonimmunologic bronchoconstrictor responses in sheep. Am Rev Respir Dis 1992;145:145-566.

Lucio J , D'Brot J , Guo C , Abraham WM , Lichtenstein LM , Kagey-Sobotka A . Immunologic mast cell-mediated responses and histamine release are attenuated by heparin. J Appl Physiol 1992;73:73-1093.

Ahmed T , Garrigo J , Danta I. Preventing bronchoconstriction in exercise-induced asthma with inhaled heparin. N Engl J Med 1993;329:329-90.

Ghosh TK , Eis PS , Mullaney JM , Ebert CL , Gill DL. Competitive, reversible, and potent antagonism of inositol 1,4,5-triphosphate-activated calcium release by heparin. J Biol Chem 1988;263:263-11075.

Chilvers ER , Challiss RAJ , Willcocks AL , Potter BVL , Barnes PJ , Nahorski SR. Characterisation of stereospecific binding sites for inositol 1,4,5-triphosphate in airway smooth muscle. Br J Pharmacol 1990;99:99-297.

Ahmed T , Hallmon J , Abraham WM. The effect of heparin on immunologically-induced tracheal smooth muscle contraction in allergic sheep (abstract). Am Rev Respir Dis 1991;143(suppl):A360.

Dolowitz DA , Dougherty TF. The use of heparin as an anti-inflammatory agent. Laryngoscope 1960;70:70-873.

Boyle JP , Smart RH , Shirey JK. Heparin in the treatment of chronic obstructive bronchopulmonary disease. Am J Cardiol 1964;14:14-25.

Cohn JE. Effects of heparin on airway resistance (abstract). Clin Res 1960;8:253.

Fine NL , Shim C , Williams MH . Objective evaluation of heparin in the treatment of asthma. Am Rev Respir Dis 1968;98:98-886.

Bardana EJ Jr , Edwards MJ , Pirofsky B. Heparin as treatment for bronchospasm of asthma. Ann Allergy 1969;27:27-108.

Tones MA , Bootman MD , Higgins BF , Lane DA , Pay GF , Lindahl U. The effect of heparin on the inositol 1,4,5-triphosphate receptor in rat liver microsomes; dependence on sulphate content and chain length. FEBS Lett 1989;252:252-105.

O'Donnell WJ , Rosenberg MA , Kelleher K , Drazen JM , Israel E. Inhaled heparin does not protect asthmatics against antigen-induced bronchoconstriction (abstract). Am Rev Respir Dis 1992;145(part 2):A422.