Abstract
Abstract
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Propranolol plasma concentrations were determined in a patient with hemolytic-uremic syndrome undergoing plasmapheresis before and after the procedure on three occasions. The mean half-life and elimination rate constant during plasmapheresis were estimated to be 25.6 percent of the values obtained without plasmapheresis. These changes suggest that plasmapheresis may influence propranolol disposition.
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References
1.
Gomeni
R
Bianchetti
G
Sega
R
Morselli
PL.
Pharmacokinetics of propranolol in normal healthy volunteers . J Pharmacokinet Biopharm
1977 ; 5 : 183 –92 .
2.
Routledge
PA
Shand
DG.
Clinical pharmacokinetics of propranolol . Clin Pharmacokinet
1979 ; 4 : 73 –90 .
3.
Bianchetti
G
Granziani
G
Brancaccio
D
Pharmacokinetics and effects of propranolol in terminal uremic patients and in patients undergoing regular dialysis treatment . Clin Pharmacokinet
1976 ; 1 : 373 –84 .
4.
Thompson
FD
Joekes
AM
Foulkes
DM.
Pharmacodynamics of propranolol in renal failure . Br Med J
1972 ; 2 : 434 –6 .
5.
Goldstein
MH
Churg
J
Strauss
L
Gribetz
D.
The hemolytic-uremic syndrome . Nephron
1979 ; 23 : 263 –72 .
6.
Karlsberg
RP
Lacher
JW
Bartecchi
CE.
Adult hemolytic-uremic syndrome (familial variant) . Arch Intern Med
1977 ; 137 : 115 –7 .
7.
Shapiro
CM
Kanter
A
Lopas
H
Rabiner
SF.
Hemolytic-uremic syndrome in adults . JAMA
1970 ; 213 : 567 –70 .
8.
Ponticelli
C
Rivolta
E
Imbasciati
E
Rossi
E
Mannucci
PM.
Hemolytic uremic syndrome in adults . Arch Intern Med
1980 ; 140 : 353 –7 .
9.
Brown
CB
Robson
JJ
Thomson
D
Clarkson
AR
Cameron
JS
Ogg
CS.
Hemolytic-uraemic syndrome in women taking oral contraceptives . Lancet
1973 ; 1 : 1479 –81 .
10.
Schoolwerth
AC
Sandler
RS
Klahr
S
Kissane
JM.
Nephrosclerosis postpartum and in women taking oral contraceptives . Arch Intern Med
1976 ; 136 : 178 –85 .
11.Massachusetts General Hospital case records (2–1973) . N Engl J Med
1973 ; 288 : 93 –9 .
12.
Gomperts
ED
Sessel
L
DuPlessis
V
Hersch
C.
Recurrent postpartum haemolytic uremic syndrome . Lancet
1978 ; 1 : 48 .
13.
Remuzzi
G
Misiani
R
Marchesi
D
Treatment of the hemolytic uremic syndrome with plasma . Clin Nephrol
1979 ; 12 : 279 –84 .
14.
Whitworth
JA
D'Apice
AJF
Kincaid-Smith
P
Shulkes
AA
Skinner
SL.
Antihypertensive effect of plasma exchange . Lancet
1978 ; 1 : 1205 .
15.
Sager
G
Nilsen
OG
Jacobsen
S.
Variable binding of propranolol in human serum . Biochem Pharmacol
1979 ; 28 : 905 –11 .
16.
Piafsky
KM
Borga
O
Odar-Cederlof
I
Johansson
C
Sjoqvist
F
. Increased plasma protein binding of propranolol and chlorpromazine mediated by disease-induced elevations of plasma α1, acid glycoprotein . N Engl J Med
1978 ; 229 : 1435 –9 .
17.
Wood
M
Shand
DG
Wood
AJJ.
Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling . Clin Pharmacol Ther
1979 ; 25 : 103 –7 .
18.
Wiegand
OW
Levy
G.
Effect of heparin administration on plasma protein binding of several drugs and bilirubin in patients with thrombotic disease . Abstract from Symposium on Drug Protein Binding: Biochemical, Pharmacokinetic and Clinical Implications. Stockholm, Sweden, March 26–28, 1980 .
19.
Wilber
B
Lo
M
Riegelman
S.
The influence of heparin administration on the plasma protein binding and disposition of propranolol . Res Commun Chem Pathol Pharmacol
1980 ; 27 : 419 –29 .