Abstract
Abstract
French
Alpha-methyldopa has been known to cause Coombs positive hemolytic anemia and extrapyramidal signs in hypertensive patients. The occurrence of these side effects has been described separately in patients. This report documents the occurrence of both reactions in a single patient.
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References
1.
Carstairs
K
Worlledge
S
Dollery
CT
Breckenridge
A
. Methyldopa and haemolytic anaemia . Lancet
1966 ; 1 : 201 .
2.
Hayes
D
. Methyldopa and hemolytic anemia . Lancet
1966 ; 1 : 365 .
3.
Schwartz
M
Dige-Petersen
H
. Methyldopa and hemolytic anemia . Lancet
1966 ; 1 : 434 .
4.
Cramond
DQ
. Aldomet®-hemolytic anemia . Med J Aust
1966 ; 1 : 955 .
5.
Clark
KGA
. Haemolysis and agranulocytosis complicating treatment with methyldopa . Br Med J
1967 ; 4 : 94 .
6.
Worlledge
SM
Carstairs
KC
Dacie
JV
. Autoimmune haemolytic anaemia associated with α-methyldopa therapy . Lancet
1966 ; 2 : 135 –9 .
7.
Weinreich
J
Rohr
J
. Auto-immune haemolytic anaemia due to long-term α-methyldopa therapy . German Med Monthly
1967 ; 12 : 431 –3 .
8.
Murad
F
. Immunohemolytic anemia during therapy with methyldopa . JAMA
1968 ; 203 : 171 –2 .
9.
Bottiger
LE
. Drug-induced haemolytic anaemia . Acta Med Scand
1973 ; 193 : 227 –31 .
10.
Spence
JM
Gitlin
N
. Alpha-methyldopa and hemolytic anemia . S Afr Med J
1973 ; 47 : 195 .
11.
de Terregrosa
M
Bulls
AG
Rivera
AAZ
. Coombs positive drug induced hemolytic anemia . Am J Clin Pathol
1970 ; 53 : 490 –3 .
12.
Distenfeld
A
Florita
C
Geftand
ML
. Hemolytic anemia induced by alpha-methyldopa . NY State J Med
1970 ;570 –73 .
13.
Hyer
SL
Knell
AJ
. Cirrhosis and haemolysis complicating methyldopa treatment . Br Med J
1977 ; 1 : 879 .
14.
Nelson
RB
Jr
Nelson
RB
III
. Methyldopa-associated intravascular hemolysis . Arch Intern Med
1977 ; 137 : 1260 –1 .
15.
Mackay
IR
Cowling
DC
Hurley
TH
. Drug-induced autoimmune disease: Haemolytic anaemia and lupus cells after treatment with methyldopa . Med J Aust
1968 ; 2 : 1047 .
16.
Hamilton
M
Jenkins
GC
Turbull
AL
. Methyldopa and hemolytic anemia . Lancet
1966 ; 1 : 549 .
17.
Sherman
JD
Love
DE
Harrington
JF
. Anemia, positive lupus and rheumatoid factors with methyldopa . Arch Intern Med
1967 ; 120 : 321 –6 .
18.
Prescott
LF
. Methyldopa and parkinsonism . Br Med J
1964 ; 5410 : 687 .
19.
Groden
BM
. Parkinsonism occurring with methyldopa treatment . Br Med J
1963 ; 5336 : 1001 .
20.
Peaston
MJT
. Parkinsonism associated with alpha-methyldopa therapy . Br Med J
1964 ; 5408 : 168 .
21.
Sourkes
TL
. Inhibition of dihydroxyphenylalanine decarboxylase by derivatives of phenylalanine . Arch Biochem
1954 ; 51 : 444 –56 .
22.
Worlledge
SM
Carstairs
KC
Dave
JV
. Autoimmune haemolytic anaemia associated with alpha-methyldopa therapy . Lancet
1966 ; 2 : 135 –9 .
23.
Lo-Buglio
AF
Jandl
JH
. Nature of alpha methyldopa red-cell antibody . N Engl J Med
1967 ; 276 : 658 –65 .
24.
Pisciotta
AV
. Drug-induced anemia . Drug Ther
1975 ; Nov: 75 –86 .
25.
Carstairs
KC
Breckenridge
A
Dollery
CT
Worlledge
SM
. Incidence of positive direct Coombs test in patients on alpha methyldopa . Lancet
1966 ; 2 : 133 –5 .
26.
Meyler
L
Herxheimer
A
, eds. Side effects of drugs . Vol. VI . Amsterdam : Excerpta Medica , 1968 : 206 .
27.
Mackay
IR
Cowling
DC
Hurley
TH
. Drug-induced auto-immune disease: Haemolytic anaemia and lupus cells after treatment with methyldopa . Med J A list
1968 ; 2 : 1047 –50 .
28.
Breckenridge
A
Dollery
CT
Worlledge
SM
Holbrow
EJ
Johnson
GD
. Positive direct Coombs test and antinuclear factor in patients treated with methyldopa . Lancet
1967 ; 2 , 1265 .
