Alpha-Methyldopa (Aldomet) Hepatitis

Horwitz D. , and Sjoerdsma A. : Use of Two Enzyme Inhibitors in Hypertension Therapy, Postgrad. Med. 34: 140–144, 1963.

Weil M. H. , Barbour B. H. , and Chesne R. B. : Alpha-Methyldopa for the Treatment of Hypertension. Clinical and Pharmacodynamic Studies. Circulation 28: 165–174, 1963.

Gilmore B. L. , and Freis E. D. : Methyldopa in the Treatment of Hypertension, Med. Ann. D.C. 34: 13–18, 1965.

Perret C. , Enrico J. F. , Montani S. , and Papalardo G. : Le Rôle de la Nécrose Hepatique dans la Pathogense de l'Acidose Lactique Spontanée. Schweiz. Med. Wochenschr. 97: 666–671, 1967.

Zarday A. , Rosenthal W. S. , and Wolff F. W. : Case Reports. Severe Liver Toxicity After Methyldopa, N. Y. State J. Med. 67: 1897–1899, 1967.

Elkington S. G. , Schrieber W. M. , and Conn H. O. : Hepatic Injury Caused by Alpha-Methyldopa, Circulation 40: 589–595, 1969.

Eliastam M. , and Holmes A. W. : Case Report. Hepatitis, Arthritis and Lupus Cell Phenomena Caused by Methyldopa, Am. J. Dig. Dis. 16: 1014–1018, 1971.

Williams E. R. , and Khan M. D. : Liver Damage in Patient on Methyldopa, J. Ther. Clin. Res. 1: 5–7, 1967.

FDA Clinical Experience Abstracts No. 670901-02700301; 690801-195-00401; 671201-06400201; 670901-17000701.

Wyburn-Mason R. , and Anastassiades C. : Jaundice and Methyldopa, Br. Med. J. 1: 780, 1969.

Morin Y. , Turmel L. , and Fortier J. : Methyldopa: Clinical Studies in Arterial Hypertension, Am. J. Med. Sci. 248: 633–639, 1964.

Cannon P. J. , and Laragh J. H. : Treatment of Hypertension with Alpha-Methyldopa, Pharmakotherapia 1: 171–184, 1963.

Horwitz D. , Pettinger W. A. , Orvis H. , Thomas R. E. , and Sjoerdsma A. : Effects of Methyldopa in Fifty Hypertensive Patients, Clin. Pharmacol. Ther. 8: 224–234, 1967.

Tysell J. E. , and Knauer C. M. : Hepatitis Induced by Methyldopa (Aldomet^®): Report of a Case and a Review of the Literature, Am. J. Dig. Dis. 16: 849–855, 1971.

Wong M. L. : Hepatocellular Damage Due to Methyldopa, Med. J. Malaya. 25: 218–219, 1971.

Brouillard R. P. , and Barrett O. : Methyldopa Associated Hepatitis. J. Am. Med. Assoc. 224: 904, 1973.

Hoyumpa A. M. , and Connell A. M. : Methyldopa Hepatitis. Am. J. Dig. Dis. 18: 213–222, 1973.

Goldstein G. B. , Lam K. C. , and Mistilis S. P. : Drug-Induced Active Chronic Hepatitis, Am. J. Dig. Dis. 18: 177–184, 1973.

Rehman O. U. , Keith T. A. , and Gall E. A. : Methyldopa-Induced Submassive Hepatic Necrosis, J. Am. Med. Assoc. 224: 1390–1392, 1973.

Schweitzer I. L. , and Peters R. L. : Acute Submassive Hepatic Necrosis Due to Methyldopa, Gastroenterology. 66: 1203–1211, 1974.

Register of Adverse Reactions, Committee on Safety of Medicines, London. Vol. 1, p. 231, (Oct.) 1971.

Leonard J. W. , Gifford R. W. Jr. , and Humphrey D. C. : Febrile Reactions to L-Alpha-Methyldopa. Report of Three Cases, Cleveland Clin. Quart. 29: 144–147, 1962.

Vorburger C. , Luthi H. , Reubi F. : Erfahrungen Mit L-Alpha-Methyldopa (Aldomet^®) in Der Hypertonie-Sprechstude, Schweiz. Med. Wochenschr. 95: 238–246, 1965.

Klapper M. S. , Richard L. S. , and Smith G. H. : Methyldopa-Chlorothiazide — A Long-Term Evaluation, S. Med. J. 63: 77–81, 1970.

Okun R. , Roth S. E. , Gordon A. , and Maxwell M. H. : The Long-Term Effectiveness of Methyldopa in Hypertension, Calif. Med. 104: 46–50, 1966.

Hutchinson J. C. , Vanderbeek R. R. , and Roediger P. M. : Evaluating Effects of Methyldopa, Penn. Med. 69: 25–33, 1966.

Gillespie L. Jr. , Oates J.A. , Crout J.R. , and Sjoerdsma A. : Clinical and Chemical Studies with α-Methyldopa in Patients with Hypertension, Circulation 25: 281–291, 1962.

Irvine R. O. H. , O'Brien K. P. , and North J. D. K. : Alpha-Methyldopa in Treatment of Hypertension, Lancet 1: 300–303, 1962.

Klapper M. S. , and Richard L. : A Clinical Study with Methyldopa as an Antihypertensive Agent, Med. Times 91: 99–106, 1963.

Colwill J. M. , Dutton A. M. , Morrissey J. , and Yu P. N. : Alpha-Methyldopa and Hydrochlorothiazide: A Controlled Study of Their Comparative Effectiveness as Antihypertensive Agents, New Engl. J. Med. 271: 696–703, 1964.

Leonard J. W. , Gifford R. W. , and Humphrey D. C. : Treatment of Hypertension with Methyldopa Alone or Combined with Diuretics and/or Guanethidine, Am. Heart J. 69: 610–618, 1965.

Smith W. M. , Bachman B. , Galante J. G. , Hanowell E. G. , Johnson W. P. , Koch C. E. , Korfmacher S. D. , and Thurm R. H. : Co-operative Clinical Trial of Alpha-Methyldopa: III. Double-Blind Control Comparison of Alpha-Methyldopa and Chlorothiazide, and Chlorothiazide and Rauwolfia, Ann. Intern. Med. 65: 657–671, 1966.

Forrester T. M. , and Sherriffs G. G. : Methyldopa and Methoserpidine in Hypertension: A Double-Blind Trial, Lancet 1: 141–142, 1967.

Miller J. P. : Febrile Reaction to Methyldopa with Hepatotoxicity, Virginia Med. Monthly 97: 159–162, 1970.

Pearson M. , Meerkin M. , and Baird C. : Aldomet Interference with the Babson Method of SGOT Analysis, Med. J. Aust. 2: 84–85, 1972.

Stead W. W. , and Texter E. C. Jr. : Isoniazid Hepatitis: Backlash of Progress, Ann. Intern. Med. 79: 125–127, 1973.

Reynolds T. B. , Peters R. L. , and Yamada S. : Chronic Active and Lupoid Hepatitis Caused by a Laxative, Oxyphenisatin. New Engl. J. Med. 285: 813–820, 1971.

Hoffbrand B. I. , Fry W. , Bunton G. L. : Cholestatic Jaundice Due to Methyldopa, Br. Med. J. 3: 559, 1974.

Toghill P. J. , Smith R. G. , Benton P. , Brown R. C. , and Matthews H. L. : Methyldopa Liver Damage. Br. Med. J. 3: 545–548, 1974.