Abstract
A 40-year-old woman developed renal tubular necrosis and liver injury following ingestion of acetaminophen 1 g 12 days after halothane anesthesia. The possibility of a synergistic association between halothane and acetaminophen, and of probable hepatic and renal damage occurring after a low dose of acetaminophen, as well as the possibility of renal tubular necrosis induced by halothane are discussed.
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References
1.
Davidson
DGD
Eastham
WN
, Acute liver necrosis following overdose of paracetamol . Br Med J
1966 ; 2 : 497 –9 .
2.
Proudfoot
AT
Wright
N.
Acute paracetamol poisoning . Br Med J
1970 ; 3 : 557 –8 .
3.
Clark
R
Thompson
RPH
Borirakchanyavat
V
, Hepatic damage and death from overdose of paracetamol . Lancet
1973 ; 1 : 66 –9 .
4.
Gilmore
IT
Tourvos
E.
Paracetamol induced acute pancreatitis . Br Med J
1977 ; 1 : 753 –4 .
5.
Krikler
DM
, Paracetamol and the kidney . Br Med J
1967 ; 2 : 615 –6 .
6.
Kerr
D.
Phenacetic nephropathy . Br Med J
1970 ; 4 : 363 –4 .
7.
Klion
FM
Schaffner
F
Popper
H.
Hepatitis after exposure to halothane . Ann Intern Med
1969 ; 71 : 467 –77 .
8.
Moult
PJA
Sherlock
S.
Halothane-related hepatitis . Q J Med
1975 ; 173 : 99 –114 .
9.
Ishikawa
M
Popovtzer
MM
Iwatsuki
S
Johansen
T
Starzle
TE
, Halothane hepatitis with renal failure treated with hemodialysis and exchange transfusion . Jpn J Surg
1974 ; 4 : 212 –5 .
10.
De Santo
NG
Esposito
R
Capodicases
G
Cirillo
D
Giordano
C.
Acute renal failure with prolonged oliguria . Minerva Nefrol
1976 ; 23 : 220 –4 .
11.
Cotton
JR
Schwartz
MM
Lindley
JD
Hunsicker
LG
, Acute renal failure following halothane anesthesia . Arch Pathol Lab Med
1976 ; 100 : 628 –9 .
12.
Davis
M
Simmons
CJ
Harrison
NG
Williams
R.
Paracetamol overdose in man; relationship between pattern of urinary metabolites and severity of liver damage . Q, J Med
1976 ; 178 : 181 –91 .
13.
Potter
WZ
Davis
DC
Mitchell
JR
Jollow
DJ
Gillette
JR
Brodie
BB
, Acetaminophen induced hepatic necrosis. Ill, cytochrome P-450-mediated covalent binding in vitro . J Pharmacol Exp Ther
1973 ; 187 : 203 –10 .
14.
McLean
AEM
Day
PA
, The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures . Biochem Pharmacol
1975 ; 24 : 37 –42 .
15.
Mitchell
JR
McMurtry
RJ
Statham
CN
Nelson
SD
, Molecular basis for several drug-induced nephropathies . Am J Med
1977 ; 62 : 518 –26 .
16.
Wilkinson
SP
Moodie
H
Arroyo
VA
Williams
R.
Frequency of renal impairment in paracetamol overdose compared with other causes of acute liver damage . J Clin Pathol
1977 ; 39 : 141 –3 .
17.
Paronetto
F
Popper
H.
Lymphocyte stimulation induced by halothane in patients with hepatitis following exposure to halothane . N Engl J Med
1977 ; 283 : 277 –80 .
18.
Cohen
EN
, Metabolites of the volatile anesthetics . Anesthesiology
1971 ; 35 : 193 –202 .
19.
Temple
RL
Cote
RA
Gorens
SW
, Massive hepatic necrosis following general anesthesia . Anesth Analg
1962 ; 41 : 586 –92 .
20.
Mazze
RI
Trudell
JR
Cousins
MJ
, Methoxyflurane metabolism and renal dysfunction. Clinical correlation in man . Anesthesiology
1971 ; 35 : 247 –52 .
21.
Creasser
C
Stoelting
RK
, Serum inorganic fluoride concentration during and after halothane, fluorine and methoxy-flurane anesthesia in man . Anesthesiology
1973 ; 39 : 537 –40 .
22.
Chang
LW
Dudley
AW
Lee
YK
Katz
Y.
Ultrastructural changes in the kidney following chronic exposure to low levels of halothane . Am J Pathol
1975 ; 78 : 225 –42 .
23.
Gillenwater
JY
Dooley
ES
Frohlich
ED
, Effects of endotoxin on renal function and hemodynamics . Am J Physiol
1963 ; 205 : 293 –7 .
24.
Appel
GB
Neu
HG
, The nephrotoxicity of antimicrobial agents . N Engl J Med
1977 ; 296 : 663 –70 .
25.
Valdivia-Barriga
V
Feldman
A
Orellana
J.
Generalized hypersensitivity with hepatitis and jaundice after use of penicillin and streptomycin . Gastroenterology
1963 ; 45 : 114 –7 .
26.
Mehrotra
TN
Gupta
SK
, Paracetamol-induced hemolytic anemia . Indian J Med Sci
1973 ; 27 : 548 –9 .
27.
Prescott
LF
, Antipyretic analgesics . In:
Dukes
MNG
, ed. Meylers' side effects of drugs . Vol 8 . New York : American Elsevier Publishing , 1975 : 154 –206 .