Blood-Forming and Coagulation Agents

Schade S. G. Cohen R. J. Conrad M. E. : Effect of Hydrochloric Acid on Iron Absorption, New Engl. J. Med. 275: 672 (Sept. 25) 1968. (OH).

American Hospital Formulary Service, American Society of Hospital Pharmacists, Washington, D.C. 20014 (R).

Hall G. J. Davis A. E. : Inhibition of Iron Absorption by Magnesium Trisilicate, Med. J. Australia 2: 95 (July 12) 1969.

Anon.: Allopurinol May Affect Iron Metabolism, J. Am. Med. Assoc. 200: 39 (May 15) 1967. (Med. News) (R).

Elking M. P. Sr. Rabat H. F. : Drug-Induced Modifications of Laboratory Test Values, Am. J. Hosp. Pharm. 25: 485 (Sept.) 1968. (R).

Jick H. : Efficacy and Toxicity of Heparin in Relation to Age and Sex, New Engl. J. Med. 279: 284 (Aug. 8) 1968. (OH).

Majoor C. L. H. : Aldosterone Suppression by Heparin, New Engl. J. Med. 279: 1172 (Nov. 21) 1968. (Letters) (OH).

Anon.: Newsletter, Division, Central Services, University Hospitals, University of Wisconsin, Vol. 6, No. 9, Sept. 1969.

Goodman L. S. Gilman A. : The Pharmacological Basis of Therapeutics, 3rd. Edition, The MacMillan Co., New York, Page 26, 1965.

Bychkov S. M. : Interaction of Heparin with Polymyxin M and Streptomycin, Vopr. Med. Khim. 12: 397, 1966.

Jackson G. G. : Current Therapeutics — Gentamicin, Practitioner 198: 855 (June) 1967.

Hansten P. D. : Oral Anticoagulant Drug Interactions, Hosp. Formulary Management 4: 20 (Jan.) 1969.

Hussar D. A. : Oral Anticoagulants — Their Interactions, J. Am. Pharm. Assoc. NS10: 78 (Feb.) 1970.

Formiller M. Cohon M. S. : Coumarin and Indandione Anticoagulants. Potentiators and Antagonists, Am. J. Hosp. Pharm. 26: 574 (Oct.) 1969.

Sandler A. I. : Interactions of Oral Coumarin Anticoagulants with Other Drugs, Drug Intelligence Clin. Pharm. 4: 146–148 (June) 1970. Annotated Bibliography: Primary references on drug interactions involving the oral anticoagulants, not included in 12, 13, 14 above.

Anton A. H. : A Drug-Induced Change in the Distribution and Renal Excretion of Sulfonamides, J. Pharmacol. Exptl. Therap. 129: 282, 1960. (OA) A wide variety of drugs including ethyl biscoumacetate displace sulfonamides from albumin binding sites, increasing antibacterial activity.

Ayd F. J. Jr. : Current Status of Thiothixene, Intern. Drug Therap. Newsletter 2: 27 (Sept.) 1967. Filotto detected a decrease in prothrombin time in 4 of 9 patients treated with thiothixene (from paper read at symposium).

Christensen L. K. Skovsted L. : Inhibition of Drug Metabolism by Chloramphenicol, Lancet 2: 1397 (Dec. 27) 1969. (OCH) The half-life of dicumarol was determined in four patients before and after administration of 2 Gm chloramphenicol per day. All patients showed a striking increase in half-life of dicumarol.

Eddy J. D. Mackinnon J. : Anticoagulants Butazolidin, Brit. Med. J. 3: 435 (Aug. 12) 1967. (CH) A patient with protime of 24–28 seconds on 10 mg warfarin was given Butazolidin for sciatic pain. The following day the protime was greater than 60 seconds. Warfarin was withdrawn and in three days the protime was within therapeutic range.

Holcenberg J. S. Bidgood M. Dixon R. L. : Studies of the Possible Therapeutic Interaction Between Cyclamate and Warfarin, Current Therap. Res. 11: 577 (Sept.) 1969. (OAH) Rats on warfarin were fed a diet containing 0.5 mg/Gm of cyclamates showed increased prothrombin time. A similar effect was not observed in 10 human volunteers.

Kater R. M. H. : Increased Rate of Clearance of Drugs from the Circulation of Alcoholics, Am. J. Med. Sci. 258: 35 (July) 1969. In a study of the plasma clearance rate of three drugs in alcoholics compared to a control group, warfarin half-life was 41.1 hours in the control group and 26.5 hours in the alcoholics. Increased drug clearance was attributed to alcoholic induction of endoplasmic reticulum of the liver.

McLaughlin G. E. McCarty D. J. Segal B. L. : Hemarthrosis Complicating Anticoagulant Therapy: Report of Three Cases, J. Am. Med. Assoc. 196: 1020 (June 13) 1966. (CH).

Welch : Clin. Pharmacol. Therap. 10: 817 (Nov-Dec.) 1969.