This case report demonstrates a rare finding of a pediatric patient with Morning Glory anomaly and Moyamoya Disease with a palatal meningeal hamartoma discovered as a mass within a previously repaired incomplete cleft of the alveolus. Oral meningeal hamartomas are exceedingly rare with only two palatal cases described and none within a cleft palate or alveolus. These findings prompt a review of oral hamartomas with meningeal subclassification. Further discussion describes the relationship of the proposed origins of meningeal hamartomas within the setting of cleft palate development.
PatilSRaoRSMajumdarB. Hamartomas of the oral cavity. Journal of International Society of Preventive and Community Dentistry. 2015;5(5):347.
2.
BarnesL. Surgical pathology of the head and neck. Vol 2. CRC press; 2000.
3.
JunaidMAhmedSQKaziMHaroonS. Oral neurovascular hamartoma: an extraordinary verdict in the oral cavity. Case Reports. 2014;2014(June 26):bcr2013200832.
4.
KreigerPAErnstLMEldenLMKazahayaKAlawiFRussoPA. Hamartomatous tongue lesions in children. Am J Surg Pathol.2007;31(8):1186‐1190.
5.
SusterSRosaiJ. Hamartoma of the scalp with ectopic meningothelial elements. A distinctive benign soft tissue lesion that may simulate angiosarcoma. Am J Surg Pathol.1990;14(1):1‐11.
6.
KimTKimJChoiJOhSKwonSJeongW. Meningothelial hamartoma of the scalp. Archives of Craniofacial Surgery. 2020;21(3):180.
7.
MarrogiASwansonPEKyriakosMWickMR. Rudimentary meningocele of the skin: clinicopathologic features and differential diagnosis. J Cutan Pathol.1991;18(3):178‐188.
8.
Di TommasoLFortunatoCEusebiV. Meningothelial hamartoma located in the forehead. Virchows Arch.2003;442(5):509.
9.
TekkeşinMSChioseaSIOzolekJA. Hamartoma of the oral cavity with ectopic meningothelial elements in infants: a rare entity with report of two cases. Head Neck Pathol.2020;14(1):268‐271.
10.
CrittendenSCSonnierGB. Meningothelial hamartoma associated with nevus sebaceus. Pediatr Dermatol.2014;31(2):208‐211.
11.
TrainorPA. Craniofacial birth defects: the role of neural crest cells in the etiology and pathogenesis of Treacher Collins syndrome and the potential for prevention. American Journal of Medical Genetics Part A. 2010;152(12):2984‐2994.
MartinelliMPalmieriACarinciFScapoliL. Non-syndromic cleft palate: an overview on human genetic and environmental risk factors. Front Cell Dev Biol.2020;8(Oct 20):592271.
14.
Le DouarinNLeDouarinNMKalcheimC. The neural crest. Cambridge university press; 1999.
15.
SomPNaidichT. Illustrated review of the embryology and development of the facial region, part 2: late development of the fetal face and changes in the face from the newborn to adulthood. American Journal of Neuroradiology. 2014;35(1):10‐18.
StromingerMB. Morning Glory Syndrome. American Academy of Ophthalmology. Oct 18; 2015. https://www.aao.org/education/disease-review/neuro-ophthalmology-morning-glory-syndrome
