Opportunistic infections (OIs) are diseases that cause infections in people whose immune systems are compromised. The purpose of this study was to assess the prevalence of OIs and associated factors among HIV-infected patients. Institutional-based cross-sectional study was done in Eastern Zone, Tigray, Ethiopia. A structured questionnaire was used to collect the data from 394 study participants through an interview method. The required sample size was determined using a single population proportion formula. Participants were selected using a systematic random sampling method. Data was entered and analyzed using SPSS version 22. Multivariable logistic regression analysis was used to find factors at p < .05. The prevalence of OIs was found to be 52% (95% CI [47.5, 57.1]). Occupation, CD4+ count, adherence to antiretroviral therapy (ART), and functional status were independently associated with OIs. Intervention measures such as improving adherence to ART should be strengthened to further reduce the burden of OIs.
AhmedA.MekonnenD.ShiferawA. M.BelaynehF.YenitM. K. (2018). Incidence and determinants of tuberculosis infection among adult patients with HIV attending HIV care in north-east Ethiopia: A retrospective cohort study. BMJ Open, 8(2), e016961.
2.
AllaisS. (2010). The implementation and impact of National Qualifications Frameworks: Report of a study in 16 countries. Geneva: ILO.
3.
CostaggiuD.SerchisuL.ClaudiaA.PinnaE.VascellariS.OrtuF.ManconiP. E.PaniA.MandasA. (2015). Determination of neutral lipid and cluster formation for screening neurocognitive impairment in human immunodeficiency virus patients. Journal of AIDS and Clinical Research, 6(11), 58–60.
4.
DamtieD.YismawG.WoldeyohannesD.AnagawB. (2013). Common opportunistic infections and their CD4 cell correlates among HIV-infected patients attending at antiretroviral therapy clinic of Gondar University Hospital, Northwest Ethiopia. BMC Research Notes, 6(1), 534.
5.
De BeaudrapP.EtardJ. F.DioufA.NdiayeI.NdèyeG. F.SowP. S.NdèyeK. C.EcochardR.DelaporteE. & ANRS 1215 Study Group. (2010). Incidence and determinants of new AIDS-defining illnesses after HAART initiation in a Senegalese cohort. BMC Infectious Diseases, 10(1), 179.
6.
DerejeN.MogesK.NigatuY.HollandR. (2019). Prevalence and predictors of opportunistic infections among HIV positive adults on antiretroviral therapy (on-ART) versus pre-ART in Addis Ababa, Ethiopia: A comparative cross-sectional study. HIV/AIDS (Auckland, NZ), 11, 229.
7.
EdwardsL. A. (2015). Establishing a pastoral care ministry for those infected and affected by HIV/AIDS at the Robert Pinn Memorial Baptist Church. Eastern University.
8.
EyasuM.BerhaneA.YohannesS. (2015). Spectrum and associated risk factors of opportunistic infections among antiretroviral therapy experienced HIV/AIDS patients in Addis Ababa, Ethiopia. Semantic Scholar.
9.
HoggR. S.YipB.KullyC.CraibK. J.O’ShaughnessyM. V.SchechterM. T.MontanerJ. S. (1999). Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens. CMAJ, 160(5), 659–665.
10.
IngabireP. M.SemitalaF.KamyaM. R.NakanjakoD. (2019). Delayed antiretroviral therapy (ART) initiation among hospitalized adults in a resource-limited settings: A challenge to the global target of ART for 90 of HIV-infected individuals. AIDS Research and Treatment, 2019, 1832152.
11.
InunguJ. N.MokotoffE. D.KentJ. B. (2001). Characteristics of HIV infection in patients fifty years or older in Michigan. AIDS Patient Care and STDs, 15(11), 567–573.
12.
IroezinduM. (2016). Disparities in the magnitude of human immunodeficiency virus-related opportunistic infections between high and low/middle-income countries: Is highly active antiretroviral therapy changing the trend?Annals of Medical and Health Sciences Research, 6(1), 4–18.
13.
IroezinduM.OfonduE.HauslerH.Van WykB. (2013). Prevalence and risk factors for opportunistic infections in HIV patients receiving antiretroviral therapy in a resource-limited setting in Nigeria. Journal of AIDS and Clinical Research, 3, 002.
14.
KhazaeiS.MolaeipoorL.RezaeianS.AyubiE.YariM.ValipourA. A. (2016). Predictors of tuberculosis in HIV/AIDS patients referred to behavioral diseases consultation center: A registry-based study in Abadan, Southwest of Iran. Shiraz E Medical Journal, 17(10), 6.
15.
KibretG. D.FeredeA.LeshargieC. T.WagnewF.KetemaD. B.AlebelA. (2019). Trends and spatial distributions of HIV prevalence in Ethiopia. Infectious Diseases of Poverty, 8(1), 90.
16.
LedergerberB.EggerM.ErardV.WeberR.HirschelB.FurrerH.BattegayM.VernazzaP.BernasconiE.OpravilM.KaufmannD. (1999). AIDS-related opportunistic illnesses occurring after initiation of potent antiretroviral therapy: The Swiss HIV Cohort Study. JAMA, 282(23), 2220–2226.
17.
MekuriaL. A.SprangersM. A.PrinsJ. M.YalewA. W.NieuwkerkP. T. (2015). Health-related quality of life of HIV-infected adults receiving combination antiretroviral therapy in Addis Ababa. AIDS Care, 27(8), 934–945.
18.
MelkamuH.SeyoumB.DessieY. (2013). Determinants of tuberculosis infection among adult HIV positives attending clinical care in western Ethiopia: A case-control study. AIDS Research and Treatment, (2), 279.
19.
MitikuH.WeldegebrealF.TeklemariamZ. (2015). Magnitude of opportunistic infections and associated factors in HIV-infected adults on antiretroviral therapy in eastern Ethiopia. HIV/AIDS (Auckland, NZ), 7, 137.
20.
MogesN.KassaG. (2014). Prevalence of opportunistic infections and associated factors among HIV positive patients taking anti-retroviral therapy in DebreMarkos Referral Hospital, Northwest Ethiopia. Journal of AIDS and Clinical Research, 5(5), 1–300.
21.
(MOH)F. M. o. H. E. (2008). Management of opportunistic infections and antiretroviral treatment in Adolescents and adults in Ethiopia. Retrieved January16, 2020, from http://www.who.int/hiv/pub/guidelines/ethiopia_art.pdf
22.
MoriskyD. E. (2008). Predictive validity of a medication adherence measure for hypertension control. Journal of Clinical Hypertension, 10, 348–354.
23.
NissapatornV.LeeC.FattQ. K.AbdullahK. A. (2003). AIDS-related opportunistic infections in Hospital Kuala Lumpur. Japanese Journal of Infectious Diseases, 56(5/6), 187–192.
24.
PodlekarevaD.MocroftA.DragstedU.B.LedergerberB.BeniowskiM.LazzarinA.WeberJ.ClumeckN.VetterN.PhillipsA. & EuroSIDA study group. (2006). Factors associated with the development of opportunistic infections in HIV-1–infected adults with high CD4+ cell counts: A EuroSIDA study. The Journal of Infectious Diseases, 194(5), 633–641.
25.
RubaihayoJ.TumwesigyeN. M.Konde-LuleJ.WamaniH.Nakku-JolobaE.MakumbiF. (2016). Frequency and distribution patterns of opportunistic infections associated with HIV/AIDS in Uganda. BMC Research Notes, 9(1), 501.
26.
SolomonF. B.AngoreB. N.KoyraH. C.TufaE. G.BerhetoT. M.AdmasuM. (2018). Spectrum of opportunistic infections and associated factors among people living with HIV/AIDS in the era of highly active anti-retroviral treatment in Dawro Zone hospital: A retrospective study. BMC Research Notes, 11(1), 604.
27.
SunH.ChenM.HsiehS.ShengW.ChangS.HsiaoC.HungC.ChangS. (2006). Changes in the clinical spectrum of opportunistic illnesses in persons with HIV infection in Taiwan in the era of highly active antiretroviral therapy. Japanese Journal of Infectious Diseases, 59(5), 311.
WachamoD.BonjaF. (2019). Opportunistic infections and associated factors among HIV/AIDS patients taking ante-retroviral therapy at selected hospitals in Sidama Zone, Southern Ethiopia: A facility-based cross-sectional study. BMC Public Health.
30.
WeldearegawiT. Z.GerenseaH.BerihuH.GideyG.WelearegayM. Z. (2020). The magnitude of opportunistic infections and associated factors in HIV-infected adults on antiretroviral therapy in southern zone Tigray, Ethiopia: A cross-sectional study. The Pan African Medical Journal, 35(126), 17839.
31.
WeldegebrealT.AhmedI.MuhiyeA.BeleteS.BekeleA.KabaM. (2018). Magnitude of opportunistic diseases and their predictors among adult people living with HIV enrolled in care: National level cross sectional study, Ethiopia. BMC Public Health, 18(1), 820.
32.
WHO. (1995). Physical status: The use of and interpretation of anthropometry, Report of a WHO Expert Committee. WHO.
XuM.FuY.KongH.ChenX.ChenY.LiL.YangQ. (2018). Bloodstream infections caused by Klebsiella pneumoniae: Prevalence of bla KPC, virulence factors and their impacts on clinical outcome. BMC Infectious Diseases, 18(1), 358.
