The persistence of chemotherapy-induced nausea (CIN) underscores the need to consider nonpharmacologic treatments such as music listening as adjunct interventions. This pilot study investigated the feasibility and overall effects of a 30-minute adjunct music listening intervention in 12 patients experiencing CIN. Music listening was started at the time participants took their as-needed antiemetic medication, and it was repeated as needed during the 5 days after chemotherapy. Data for 66 music listening engagements were collected. A significant reduction of nausea severity (t = 10.97, p < .001) and distress (t = 9.86, p < .001) was noted overall, as well as significant reductions when examining the acute and delayed phases of nausea individually. Qualitative data on study feasibility demonstrated the intervention was well received by participants and held minimal operational difficulty. Investigator feasibility data suggested good understanding of data collection tools. Improvements to the study design have been collected and will form the basis of the future randomized controlled trial.
ArrudaM. A.GarciaM. A.GarciaJ. B. (2016). Evaluation of the effects of music and poetry in oncologic pain relief: A randomized clinical trial. Journal of Palliative Medicine, 19(9), 943–948. https://doi.org/10.1089/jpm.2015.0528
2.
AudhyaT.AdamsJ. B.JohansenL. (2012). Correlation of serotonin levels in CSF, platelets, plasma, and urine. Biochimica et Biophysica Acta (BBA)-General Subjects, 1820(10), 1496–1501.
3.
BergerM. J.EttingerD. S.AstonJ.BarbourS.BergsbakenJ.BiermanP. J.BrandtD.DolanD. E.EllisG.KimE. J.Kirkega ardS.KlothD. D.LagmanR.LimD.LoprinziC.MaC. X.MaurerV.MichaudL. B.NabellL. M.. . . HughesM. (2017). NCCN guidelines insights: Antiemesis, Version 2.2017. Journal of the National Comprehensive Cancer Network: JNCCN, 15(7), 883–893. https://doi.org/10.6004/jnccn.2017.0117
4.
BilgicS.AcarogluR. (2017). Effects of listening to music on the comfort of chemotherapy patients. Western Journal of Nursing Research, 39(6), 745–762. https://doi.org/10.1177/0193945916660527
5.
BozcukH.ArtacM.KaraA.OzdoganM.SualpY.TopcuZ.KaraagacliA.YildizM.SavasB. (2006). Does music exposure during chemotherapy improve quality of life in early breast cancer patients? A pilot study. Medical Science Monitor, 12(5), 200–205.
6.
BradtJ.PotvinN.KesslickA.ShimM.RadlD.SchriverE.GracelyE. J.Komarnicky-KocherL. T. (2015). The impact of music therapy versus music medicine on psychological outcomes and pain in cancer patients: A mixed methods study. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer, 23(5), 1261–1271. https://doi.org/10.1007/s00520-014-2478-7
7.
BroM. L.JespersenK. V.HansenJ. B.VuustP.AbildgaardN.GramJ.JohansenC. (2017). Kind of blue: A systematic review and meta-analysis of music interventions in cancer treatment. Psycho-Oncology, 27(2), 386–400. https://doi.org/10.1002/pon.4470
ChengK. K.WongE. M.LingW. M.ChanC. W.ThompsonD. R. (2009). Measuring the symptom experience of Chinese cancer patients: A validation of the Chinese version of the memorial symptom assessment scale. Journal of Pain and Symptom Management, 37(1), 44–57. https://doi.org10.1016/j/jpainsymman.2007.12.019
11.
ChouR.GordonD. B.de Leon-CasasolaO. A.RosenbergJ. M.BicklerS.BrennanT.CarterT.CassidyC. L.ChittendenE. H.DegenhardtE.GriffithS.ManworrenR.McCarbergB.MontgomeryR.MurphyJ.PerkalM. F.SureshS.SlukaK.StrasselsS.. . . WuC. L. (2016). Management of postoperative pain: A clinical practice guideline from the American pain society, the American society of regional anesthesia and pain medicine, and the American society of anesthesiologists’ committee on regional anesthesia, executive committee, and administrative council. The Journal of Pain, 17(2), 131–157. https://doi.org/10.1016/j.jpain.2015.12.008
12.
DapuetoJ. J.del Carmen AbreuM.FrancolinoC.LevinR. (2015). Psychometric assessment of the MSAS-SF and the FACIT-Fatigue scale in Spanish-speaking patients with cancer in Uruguay. Journal of Pain and Symptom Management, 47(5), 936–945. https://doi.org/10.1016/j.jpainsymman.2013.06.020
13.
EversS.SuhrB. (2000). Changes of the neurotransmitter serotonin but not of hormones during short time music perception. European Archives of Psychiatry and Clinical Neuroscience, 250, 144–147.
14.
EzzoneS.BakerC.RosseletR.TerepkaE. (1998). Music as an adjunct to antiemetic therapy. Oncology Nursing Forum, 25(9), 1551–1556.
15.
FaulF.ErdfelderE.BuchnerA.LangA. G. (2009). Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160.
16.
FirmezaM. A.RodriguesA. B.MeloG. A.AguiarM. I.CunhaG. H.OliveiraP. P.GrangeiroA. S. (2017). Control of anxiety through music in a head and neck outpatient clinic: A randomized clinical trial. Revest da Escola de Enfleurage da USP, 51, e03201. https://doi.org/10.1590/s1980-220x2016030503201
17.
FrankJ. (1985). The effects of music therapy and guided visual imagery on chemotherapy induced nausea and vomiting. Oncology Nursing Forum, 12(5), 47–52.
18.
GimenoM. M. (2010). The effect of music and imagery to induce relaxation and reduce nausea and emesis in patients with cancer undergoing chemotherapy treatment. Music and Medicine, 2(3), 174–181. https://doi.org/10.1177/1943862110374622
19.
GrunbergS. M.DeusonR. R.MavrosP.GelingO.HansenM.CrucianiG.DanieleB.De PouvourvilleG.RubensteinE. B.DaugaardG. (2004). Incidence of chemotherapy-induced nausea and emesis after modern antiemetics. Cancer, 100(10), 2261–2268. https://doi.org/10.1002/cncr.20230
20.
HeskethP. J.GrunbergS. M.HerrstedtJ.de WitR.GrallaR. J.CaridesA. D.TaylorA.EvansJ. K.HorganK. J. (2006). Combined data from two phase III trials of the NK1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid for prevention of chemotherapy-induced nausea and vomiting: Effect of gender on treatment response. Supportive Care in Cancer, 14, 354–360. https://doi.org/10.1007/s00520-005-0914-4
21.
HoseiniS. A. (2009). Effect of music therapy on chemotherapy nausea and vomiting in children with malignancy. Journal of Faculty of Nursing and Midwifery, 15(2), 5–14.
22.
HuangS. T.GoodM.ZauszniewskiJ. A. (2010). The effectiveness of music in relieving pain in cancer patients: A randomized controlled trial. International Journal of Nursing Studies, 47(11), 1354–1362. https://doi.org/10.1016/j.ijnurstu.2010.03.008
23.
KaradagE.UğurÖÇetinayakO. (2019). The effect of music listening intervention applied during radiation therapy on the anxiety and comfort level in women with early-stage breast cancer: A randomized controlled trial. European Journal of Integrative Medicine, 27, 39–44.
24.
KaragozogluS.TekyasarF.YilmazF. A. (2012). Effects of music therapy and guided visual imagery on chemotherapy-induced anxiety and nausea-vomiting. Journal of Clinical Nursing, 22, 39–50. https://doi.org/10.1111/jocn.12030
25.
LeeJ. H. (2016). The effects of music on pain: A meta-analysis. Journal of Music Therapy, 53(4), 430–477. https://doi.org/10.1093/jmt/thw012
26.
LiX. M.YanH.ZhouK. N.DangS. N.WangD. L.ZhangY. P. (2011). Effects of music therapy on pain among female breast cancer patients after radical mastectomy: Results from a randomized controlled trial. Breast Cancer Research and Treatment, 128(2), 411–419. https://doi.org/10.1007/s10549-011-1533-z
27.
LiaoJ.YangY. F.CohenL.ZhaoY. C.XuY. (2013). Effects of Chinese medicine five-element music on the quality of life for advanced cancer patients: A randomized controlled trial. Chinese Journal of Integrative Medicine, 19(10), 736–740. https://doi.org/10.1007/s11655-013-1593-5
28.
LimaT. U.MouraE.OliveiraC.LealR.Nogueira NetoJ.PereiraE. C.NascimentoR.OliveiraE.LealP. (2020). Impact of a music intervention on quality of life in breast cancer patients undergoing chemotherapy: A randomized clinical trial. Integrative Cancer Therapies, 19, 1534735420938430. https://doi.org/10.1177/1534735420938430
29.
LoprinziC. (2017). Chemotherapy-induced nausea and vomiting (CINV): Perceptions, mechanisms, and treatment guidelines. Journal of Managed Care Medicine, 20(2), 48–52.
30.
LymanG. H.GreenleeH.BohlkeK.BaoT.DeMicheleA. M.DengG. E.FouladbakhshJ. M.GilB.HershmanD. L.MansfieldS.MussallemD. M.MustianK. M.PriceE.RafteS.CohenL. (2018). Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 36(25), 2647–2655. https://doi.org/10.1200/JCO.2018.79.2721
31.
MelnykB. M.Morrison-BeedyD. (2012). Setting the stage for intervention research: The “so what” factor. In MelnykB. M.Morrison-BeedyD. (Eds.), Intervention Research: Designing, Conducting, Analyzing, and Funding (pp. 1–9). Springer Publishing Company.
32.
MoradianS.WalsheC.ShahidsalesS.Ghavam NasiriM. R.PillingM.MolassiotisA. (2015). Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting: A feasibility study using a randomized controlled trial design. European Journal of Oncology Nursing, 19(3), 282–291. https://doi.org/10.1016/j.ejon.2014.10.016
33.
NavariR. M.AaproM. (2016). Antiemetic prophylaxis for chemotherapy-induced nausea and vomiting. New England Journal of Medicine, 374, 1356–1367. https://doi.org/10.1056/NEJMra1515442
34.
NeumanB. M.FawcettJ. (2011). The Neuman systems model. Pearson.
35.
ParkH. S.WonH. S.AnH. J.ChoS. S.KimH. H.SunD. S.KoY. H.ShimB. Y. (2020). Elevated serum substance p level as a predictive marker for moderately emetogenic chemotherapy-induced nausea and vomiting: A prospective cohort study. Cancer Medicine, 10(3), 1057–1065. http://doi.org/10.1002/cam4.3693
36.
PirriC.KatrisP.TrotterJ.BaylissE.BennettR.DrummondP. (2011). Risk factors at pretreatment predicting treatment-induced nausea and vomiting in Australian cancer patients: A prospective, longitudinal, observational study. Supportive Care in Cancer, 19, 1549–1563. https://doi.org/10.1007/s00520-010-0982-y
37.
RamaswamiA.SilvermanM. J. (2019). A neuroscience-based rationale for patient-preferred live music as a receptive music therapy intervention for adult medical patients: A literature review. An Interdisciplinary Journal of Music Therapy, 11(2), 2459–3338.
38.
RobbS. L.CarpenterJ. S.BurnsD. S. (2011). Reporting guidelines for music-based interventions. Music and Medicine, 3(4), 271–279. https://doi.org/10.1177/1943862111420539
39.
RoscoeJ. A.MorrowG. R.ColagiuriB.HecklerC. E.PudloB. D.ColmanL.HoelzerK.JacobsA. (2010). Insight into the prediction of chemotherapy-induced nausea. Supportive Care in Cancer, 18, 869–876. https://doi.org/10.1007/s00520-009-0723-2
40.
SaboC. E.MichaelS. R. (1996). The influence of personal message with music on anxiety and side effects associated with chemotherapy. Cancer Nursing, 19(4), 283–289. https://doi.org/10.1097/00002820-199608000-00004
41.
StandleyJ. M. (1992). Clinical applications of music and chemotherapy: The effects on nausea and emesis. Music Therapy Perspectives, 10, 27–35.
42.
UomoriT.HorimotoY.MogushiK.MatsuokaJ.SaitoM. (2017). Relationship between alcohol metabolism and chemotherapy-induced emetic events in breast cancer patients. Breast Cancer (Tokyo, Japan), 24(5), 702–707. https://doi.org/10.1007/s12282-017-0761-4
43.
ZimmermanL.PozehlB.DuncanK.SchmitzR. (1989). Effects of music in patients who had chronic cancer pain. Western Journal of Nursing Research, 11(3), 298–309. https://doi.org/10.1177/019394598901100304
