Cognitive rehabilitation is a potential intervention for cognitive but also motor disorders in Parkinson's disease (PD).
Objective
To investigate the effects of cognitive rehabilitation on balance and motor symptoms in PD.
Methods
A randomized controlled trial in a community setting, in people with mild-to-moderate PD (Hoehn and Yahr ≤ III) without cognitive impairment (MoCA ≥ 24) was conducted. Thirty-nine participants were randomly allocated to receive a cognitive intervention (Experimental Group, n = 20) or no intervention (Control Group, n = 19). The experimental protocol involved self-administered cognitive rehabilitation using the NeuronUP platform, focusing on sustained attention and information processing speed training (30 min/day, 3 days/week, 4 weeks). The Berg Balance Scale (BBS) was the main outcome. Motor variables included UPDRS-III, Percentage of Limits of Stability (%LOS) and Timed Up and Go Test (TUG). Neuropsychological variables included TMT-A, TMT-B, Processing Speed (Digit Symbol-Coding and Symbol Search) and Stroop test.
Results
At post-intervention, marginal improvements were observed in BBS (Mean Difference = 2.23 points, 95%CI [−0.03, 4.49], p = 0.053) and significant improvements in the UPDRS-III (Mean Difference = −4.02 points, 95%CI [−7.82, −0.23], p = 0.039). No significant improvements were found in the rest of the motor and cognitive variables.
Conclusions
Self-administered cognitive training did not improve balance or cognition but significantly reduced motor symptom severity in PD. The effect of more intensive or in-person cognitive rehabilitation protocols on balance needs to be evaluated.
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