Purpose: This paper presents an institutional and organizational comparative case analysis of practice research platforms in social work, which are institutionally embedded partnerships of university-based research centers, organizations delivering social services and healthcare, and other knowledge intermediaries that connect social work practice and research. Methods: An institutional and organizational comparative case analysis is presented concerning four practice research platforms from the USA, Finland, Australia, and Singapore. Results: We identify similarities and differences in the platforms’ purpose and basic goals, administration and financing, and substantive and methodological foci in the development of social work practice research studies. Discussion: We conclude by identifying ways for practice research platforms, and thus social work practice research projects, to be sustained amidst future challenges. We also note ongoing needs for institutional support for practice research, involving co-leadership (involving academics, university and agency administrators and practitioners, and service users and advocates) and stable, diversified funding.