Cellular membranes, nature’s original multifunctional composite material, play key roles in sensing, actuation, energy storage and conversion, communication, and even computing in living creatures. These capabilities stem from their fluid architectures replete with functional biomolecules. Our research has worked to advance the assembly, characterization and use of fluid, biomimetic membranes as bio-inspired platforms for stimuli-responsive and adaptive materials. This article briefly reviews our work to develop biomimetic membranes and their applications, including as artificial synapses and neurons in low-power neuromorphic computing.
BanghartMBorgesKIsacoffE, et al. (2004) Light-activated ion channels for remote control of neuronal firing. Nature Neuroscience7: 1381–1386. DOI: 10.1038/nn1356.
2.
BashamCMPremadasaUIMaYZ, et al. (2021) Nanoparticle-induced disorder at complex liquid–liquid interfaces: Effects of curvature and compositional synergy on functional surfaces. ACS Nano15: 14285–14294. DOI: 10.1021/acsnano.1c02663.
3.
BoreykoJBPolizosGDatskosPG, et al. (2014) Air-stable droplet interface bilayers on oil-infused surfaces. Proceedings of the National Academy of Sciences111: 7588–7593. DOI: 10.1073/pnas.1400381111.
4.
HasanMSSchumanCDNajemJS, et al. (2018) Biomimetic, soft-material synapse for neuromorphic computing: From device to network. In: 2018 IEEE 13th Dallas Circuits and Systems Conference (DCAS). IEEE, pp. 1–6.
5.
KonerSNajemJSHasanMS, et al. (2019) Memristive plasticity in artificial electrical synapses via geometrically reconfigurable, gramicidin-doped biomembranes. Nanoscale11: 18640–18652. DOI: 10.1039/C9NR07288H.
6.
KonerSTawfikJMashaliF, et al. (2022) Homogeneous hybrid droplet interface bilayers assembled from binary mixtures of DPhPC phospholipids and PB-b-PEO diblock copolymers. Biochimica et Biophysica Acta (BBA)-Biomembranes1864: 183997.
7.
LangtonMJ (2021) Engineering of stimuli-responsive lipid-bilayer membranes using supramolecular systems. Nature Reviews Chemistry5: 46–61. DOI: 10.1038/s41570-020-00233-6.
8.
Makhoul-MansourMMMarajJJSarlesSA (2022) Bioderived materials for stimuli-responsive, adaptive, and neuromorphic systems: A perspective. Journal of Composite Materials3: 00219983221135055. DOI: 10.1177/00219983221135055.
9.
Makhoul MansourMMarajJJPyronRJ, et al. (2024) Biomolecular neuristors from functionalized lipid membranes. Advanced Functional Materials n/a: 2409296. DOI: 10.1002/adfm.202409296.
10.
MarajJJHaughnKPTInmanDJ, et al. (2023) Sensory adaptation in biomolecular memristors improves reservoir computing performance. Advanced Intelligent Systems5: 2300049. DOI: 10.1002/aisy.202300049.
11.
MarajJJNajemJSRingleyJD, et al. (2021) Short-term facilitation-then-depression enables adaptive processing of sensory inputs by ion channels in biomolecular synapses. ACS Applied Electronic Materials3: 4448–4458. DOI: 10.1021/acsaelm.1c00610.
MashaliFBashamCMXuX, et al. (2023) Simultaneous electrophysiology and imaging reveal changes in lipid membrane thickness and tension upon uptake of amphiphilic gold nanoparticles. Langmuir39: 15031–15045. DOI: 10.1021/acs.langmuir.3c01973.
14.
NajemJSHasanMSWilliamsRS, et al. (2019) Dynamical nonlinear memory capacitance in biomimetic membranes. Nature Communications10: 3239. DOI: 10.1038/s41467-019-11779-5.
15.
NajemJSTaylorGJWeissRJ, et al. (2018) Memristive ion channel-doped biomembranes as synaptic mimics. ACS Nano12: 4702–4711. DOI: 10.1021/acsnano.8b01282.
16.
NguyenMASrijantoBCollierCP, et al. (2016) Hydrodynamic trapping for rapid assembly and in situ electrical characterization of droplet interface bilayer arrays. Lab on a Chip16: 3576–3588. DOI: 10.1039/c6lc00810k.
17.
TaylorGNguyenMAKonerS, et al. (2019) Electrophysiological interrogation of asymmetric droplet interface bilayers reveals surface-bound alamethicin induces lipid flip-flop. Biochimica et Biophysica Acta (BBA)-Biomembranes1861: 335–343. DOI: 10.1016/j.bbamem.2018.07.001.
18.
TaylorGJVenkatesanGACollierCP, et al. (2015) Direct in situ measurement of specific capacitance, monolayer tension, and bilayer tension in a droplet interface bilayer. Soft Matter11: 7592–7605. DOI: 10.1039/c5sm01005e.
19.
VenkatesanGALeeJFarimaniAB, et al. (2015) Adsorption kinetics dictate mono layer self-assembly for both lipid-in and lipid-out approaches to droplet interface bilayer formation. Langmuir31: 12883–12893. DOI: 10.1021/acs.langmuir.5b02293.
20.
VenkatesanGASarlesSA (2016) Droplet immobilization within a polymeric organogel improves lipid bilayer durability and portability. Lab on a Chip16: 2116–2125. DOI: 10.1039/C6LC00391E.
21.
VenkatesanGATaylorGJBashamCM, et al. (2018) Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids. Biomicrofluidics12: 24101. DOI: 10.1063/1.5016523.
