Cardiovascular disease (CVD) is one of the most common chronic illnesses in the Eastern Mediterranean. There have been few studies on medication adherence in Arab patients with CVD.
Aim:
To investigate the rates and the reasons for medication adherence in Arab patients with CVD.
Methodology:
The Joanna Briggs Institute methodology for prevalence systematic reviews was used. MEDLINE, EMCARE, CINAHL, Scopus, Science Direct, PsychINFO, and the Cochrane Central Register of Controlled Trials were searched.
Results:
Thirteen quantitative studies on medication adherence in Arab adult CVD patients were included.
Pooled data from nine studies demonstrated that 53.2% (95% confidence interval = [51.2%, 55.1%]) of patients were adherent to their medications. Reasons for nonadherence to medication include personal factors, understanding, and complexity of treatment regimes, medication knowledge and structural barriers.
Conclusion:
Medication adherence appears to have a social gradient, and families should be actively involved in future strategies to increase medication adherence.
Abu KamelA. (2016). “There is a dependent patient in our home”: Designing and disseminating a family caregiving program through YouTube. Journal of the Egyptian Public Health Association, 91(2), 95–99.
2.
Al-DakenL. I.EshahN. F. (2017). Self-reported adherence to therapeutic regimens among patients with hypertension. Clinical and Experimental Hypertension, 39(3), 264–270. https://doi.org/10.1080/10641963.2016.1247164
3.
Al-GanmiA. H. A.AlotaibiA.GholizadehL.PerryL. (2020). Medication adherence and predictive factors in patients with cardiovascular disease: A cross-sectional study. Nursing and Health Sciences, 22, 454–463. https://doi.org/10.1111/nhs.12681
4.
AlhalaiqaF.DeaneK. H.NawaflehA. H.ClarkA.GrayR. (2012). Adherence therapy for medication non-compliant patients with hypertension: A randomised controlled trial. Journal of Human Hypertension, 26(2), 117–126. https://doi.org/10.1038/jhh.2010.133
5.
AlhomoudF.SmithF.AslanpourZ.DhillonS. (2016). Medication adherence and its associated factors among South Asian and Middle Eastern patients with chronic diseases in the UK. International Journal of Clinical Pharmacy, 38(6), 494–495.
6.
AlomariA.AlananzehI.LordH.FernandezR. (2022). The adherence to healthy lifestyle among Arab patients with cardiovascular disease: Mixed-method review. Journal of Transcultural Nursing, 33(1), 33–40. https://doi.org/10.1177/10436596211035176
7.
AloudahN. M.ScottN. W.AljadheyH. S.Araujo-SoaresV.AlrubeaanK. A.WatsonM. C. (2018). Medication adherence among patients with type 2 diabetes: A mixed methods study. PLOS ONE, 13(12), Article e0207583.
8.
Al-NoumaniH.WuJ. R.BarksdaleD.KnaflG.AlKhasawnehE.SherwoodG. (2018). Health beliefs and medication adherence in Omanis with hypertension. Journal of Cardiovascular Nursing, 33(6), 518–526. https://doi.org/10.1097/jcn.0000000000000511
9.
Al-RamahiR. (2015). Adherence to medications and associated factors: A cross-sectional study among Palestinian hypertensive patients. Journal of Epidemiology and Global Health, 5(2), 125–132. https://doi.org/10.1016/j.jegh.2014.05.005
10.
Al SolamiF. J. A.HouX.-Y.Correa-VelezI. (2012). Factors affecting antihypertensive treatment adherence: A Saudi Arabian perspective. Clinical Medicine Diagnostics, 2(4), 27–32.
11.
BoulleP.Sibourd-BaudryA.AnsbroE.MerinoD. P.SalehN.ZeidanR. K.PerelP. (2019). Cardiovascular disease among Syrian refugees: A descriptive study of patients in two Medecins Sans Frontieres clinics in Northern Lebanon. Conflict and Health, 13(1), Article 37. https://doi.org/10.1186/s13031-019-0217-x
12.
ChandraM.DuriA.SmithM. (2019). Prevalence of chronic disease risk factors in 35-to 44-year-old humanitarian arrivals to New South Wales (NSW), Australia. Australian Journal of Primary Health, 25(1), 19–23.
13.
ChowdhuryR.KhanH.HeydonE.ShroufiA.FahimiS.MooreC.MantJ. (2013). Adherence to cardiovascular therapy: A meta-analysis of prevalence and clinical consequences. European Heart Journal, 34(38), 2940–2948.
14.
DiMatteoM. R. (2004). Social support and patient adherence to medical treatment: A meta-analysis. Health Psychology, 23(2), 207–218.
15.
HaddadC.HallitS.SalhabM.HajjA.SarkisA.AyoubE. N.KhabbazL. R. (2018). Association between adherence to statins, illness perception, treatment satisfaction, and quality of life among Lebanese patients. Journal of Cardiovascular Pharmacology and Therapeutics, 23(5), 414–422. https://doi.org/10.1177/1074248418769635
16.
JaamM.IbrahimM. I. M.KheirN.HadiM. A.DiabM. I.AwaisuA. (2018). Assessing prevalence of and barriers to medication adherence in patients with uncontrolled diabetes attending primary healthcare clinics in Qatar. Primary Care Diabetes, 12(2), 116–125.
KhayyatS. M.KhayyatS. M.Hyat AlhazmiR. S.MohamedM. M.Abdul HadiM. (2017). Predictors of medication adherence and blood pressure control among Saudi hypertensive patients attending primary care clinics: A cross-sectional study. PLOS ONE, 12(1), Article e0171255. https://doi.org/10.1371/journal.pone.0171255
19.
MohammadY.AmalA. H.SanaaA.SamarR.SalamZ.WafaB.PascaleS. (2016). Evaluation of medication adherence in Lebanese hypertensive patients. Journal of Epidemiology and Global Health, 6(3), 157–167. https://doi.org/10.1016/j.jegh.2015.07.002
20.
MoherD.LiberatiA.TetzlaffJ.AltmanD. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLOS Medicine, 6(7), Article e1000097.
21.
MoolaS.MunnZ.TufanaruC.AromatarisE.SearsK.SfetcuR.CurrieM.LisyK.QureshiR.MattisP.MuP. (2020). Chapter 7: Systematic reviews of etiology and risk. In AromatarisE.MunnZ. (Eds.), Manual for Evidence Synthesis (Vol. 2020). JBI. https://synthesismanual.jbi.global
22.
MunnZ.MoolaS.LisyK.RiitanoD.TufanaruC. (2020). Systematic reviews of prevalence and incidence. In AromatarisE.MunnZ. (Eds.), JBI manual for evidence synthesis. Joanna Briggs Institute. https://synthesismanual.jbi.global
23.
MurphyA.PalafoxB.O’DonnellO.StucklerD.PerelP.AlHabibK. F.McKeeM. (2018). Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: Evidence from the PURE observational study. Lancet Global Health, 6(3), e292–e301. https://doi.org/10.1016/s2214-109x(18)30031-7
24.
MusaigerA. O.Al-HazzaaH. M. (2012). Prevalence and risk factors associated with nutrition-related noncommunicable diseases in the Eastern Mediterranean region. International Journal of General Medicine, 5, 199–217.
25.
OsmanF. A.MohamedH. H.AlhajN. A. (2019). Non-adherence to antihypertensive medication and its associated factors among cardiac patients at Alshaab referred clinic, November2017. Sudan Journal of Medical Sciences, 14(2), 24–37. https://doi.org/10.18502/sjms.v14i2.4689
26.
RitcheyM.ChangA. P.PowersC.LoustalotF.SchiebL.KetchamM.HongY. L. (2016). Vital signs: Disparities in antihypertensive medication nonadherence among Medicare part D beneficiaries. Morbidity and Mortality Weekly Report, 65(36), 967–976. https://doi.org/10.15585/mmwr.mm6536e1
27.
SaartiS.HajjA.KaramL.JabbourH.SarkisA.El OstaN.Rabbaa KhabbazL. (2016). Association between adherence, treatment satisfaction and illness perception in hypertensive patients. Journal of Human Hypertension, 30(5), 341–345. https://doi.org/10.1038/jhh.2015.86
28.
SantoK.KirkendallS.LabaT.-L.ThakkarJ.WebsterR.ChalmersJ.RedfernJ. (2016). Interventions to improve medication adherence in coronary disease patients: A systematic review and meta-analysis of randomised controlled trials. European Journal of Preventive Cardiology, 23(10), 1065–1076.
29.
SchedlbauerA.SchroederK.PetersT.FaheyT. (2004). Interventions to improve adherence to lipid lowering medication. Cochrane Database of Systematic Reviews, 12, Article CD004371.
30.
SimoniJ. M.HuhD.WilsonI. B.ShenJ.GogginK.ReynoldsN. R.LiuH. (2012). Racial/ethnic disparities in ART adherence in the United States: Findings from the MACH14 study. Journal of Acquired Immune Deficiency Syndromes, 60(5), 466–472.
31.
SinghP.LeBlancP.King-ShierK. (2021). Interventions to improve medication adherence in ethnically diverse patients: A narrative systematic review. Journal of Transcultural Nursing, 32, 600–613.
32.
TufanaruC.MunnZ.AromatarisE.CampbellJ.HoppL. (2020). Systematic reviews of effectiveness. In AromatarisE.MunnZ. (Eds.), JBI manual for evidence synthesis. Joanna Briggs Institute. https://synthesismanual.jbi.global
ZalloumN. A.Abu FarhaR.Abu Ruqa’aA. M.KhdairA. A.BashetiI. A. (2015). Blood pressure home monitoring in hypertensive patients attending a tertiary health facility in Amman, Jordan: Effect on disease control and adherence rate. Tropical Journal of Pharmaceutical Research, 14(3), 533–538. https://doi.org/10.4314/tjpr.v14i3.24
36.
ZyoudS. H.Al-JabiS. W.SweilehW. M.MoriskyD. E. (2013). Relationship of treatment satisfaction to medication adherence: findings from a cross-sectional survey among hypertensive patients in Palestine. Health and Quality of Life Outcomes, 11, 191. https://doi.org/10.1186/1477-7525-11-191
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