3 Case reports of Edema Associated with Quetiapine

Abstract

Background

Edema associated with quetiapine has been described in only one case report to date and represents a potentially serious adverse reaction.

Methods

We present a case series of 3 patients who developed bilateral leg edema following initiation of quetiapine.

Results

One of these patients had a recurrence of edema with subsequent rechallenge. Another patient developed quetiapine-induced edema following a prior episode of olanzapine-induced edema. All 3 cases present a compelling temporal relationship between the drug challenge and the adverse event.

Conclusion

Prompt recognition and intervention with discontinuation of the offending agent is important for this potentially serious, seemingly idiosyncratic vascular complication.