Our objective was to report and describe a case of quetiapine-induced dystonia in an older lady with psychosis. Quetiapine is a second-generation antipsychotic and known to be rare in causing extrapyramidal side effects with rates similar to placebo.
Conclusions:
There have been few documented cases of quetiapine-induced dystonia. It is important to be vigilant and consider the development of dystonia in patients who may not fit the typical risk profile.
van HartenPHoekHKahnR. Acute dystonia induced by drug treatment. BMJ1999; 319: 623–626.
4.
CaligiuriMJesteDLacroJ.Antipsychotic-induced movement disorders in the elderly. Drugs Aging2000; 17: 363–384.
5.
FigielGKrishnanRDoraiswamyMet al. Caudate hyperintensities in elderly depressed patients with neuroleptic-induced parkinsonism. J Geriatr Psychiatry Neurol1990; 4: 86-89.
6.
LeeyJSettersBMurphyPet al. Quetiapine-induced dystonia and agitation in Parkinson’s disease with dementia: a case report. J Am Geriatr Soc2009; 57: 918-919.
7.
DesarkerPSinhaV.Quetiapine-induced acute dystonia and akathisia. Aust N Z J Psychiatry2006; 6: 607-608.
8.
KroppSHauserUZiegenbeinM.Quetiapine-associated acute dystonia. Ann Pharmacother2004; 4: 719-720.
9.
JonnalagadaJNortonJ.Acute dystonia with quetiapine. Clin Neuropharmacol2000; 23: 229-230.
10.
SpinaEde LeonJ.Metabolic drug interactions with newer antipsychotics: a comparative review. Basic Clin Pharmacol2007; 100: 4-22.
11.
CaroffSHurfordILybrandJet al. Movement disorders induced by antipsychotic drugs: implications of the CATIE schizophrenia trial. Neurol Clin2011; 29: 127-148.