Acute aluminium phosphide poisoning is an extremely lethal poisoning. Ingestion is usually suicidal in intent, uncommonly accidental and rarely homicidal. Unfortunately the absence of a specific antidote results in very high mortality and the key to treatment lies in rapid decontamination and institution of resuscitative measures. This article aims to identify the salient features and mechanism of aluminium phosphide poisoning along with its management strategies and prognostic variables.
HackenbergU.Chronic ingestion by rats of standard diet treated with aluminum phosphide. Toxicol Appl Pharmacol1972; 23(1): 147–58.
2.
KabraS.G., NarayananR.Aluminium phosphide: worse than Bhopal [Letter]. Lancet1988; 1(8598): 1333.
3.
SiwachS.B., GuptaA.The profile of acute poisonings in Haryana-Rohtak Study. J Assoc Physicians India1995; 43(11): 756–9.
4.
SinghS., WigN., ChaudharyD., SoodN.K., SharmaB.K.Changing pattern of acute poisoning in adults: experience of a large North-west Indian Hospital (1970–1989). J Assoc Physicians India1997; 45(3): 194–7.
5.
SinghS., SharmaB.K., WahiP.L., AnandB.S., ChughK.S.Spectrum of acute poisoning in adults (10 year experience). J Assoc Physicians India1984; 12(7): 561–3.
6.
LallS.B., PeshinS.S., SethS.D.Acute poisonings. A ten years retrospective hospital based study. Ann Natl Acad Med Sci (India)1994; 30: 35–9.
7.
NakakitaH., KatsumataY., OzawaT.The effect of phosphine on respiration of rat liver mitochondria. J biochem1971; 69(3): 589–93.
8.
ChefurkaW., KashiK.P., BondE.J.The effect of phosphine on electron transport in mitochondria. Pest Biochem Physiol1976; 6: 65–84.
9.
ChughS.N., AroraV., SharmaA., ChughK.Free radical scavengers and lipid peroxidation in acute aluminium phosphide poisoning. Indian J Med Res1996; 104: 190–3.
10.
SepahaG.C., BharaniA.K., JainS.M., RamanP.G.Acute aluminium phosphide poisoning. J Indian Med Assoc1985; 83(11): 378–9.
11.
GroverA., BansalS.Aluminium phosphide poisoning. Manual of medical emergencies, 1st ed. New Delhi: M M Healthcare; 1997. p. 76–9.
12.
ChughS.N.Aluminium phosphide poisoning with special reference on its diagnosis and management [Review article]. J Med Assoc Clin Med1995; 1: 20–2.
13.
ChughS.N., RamS., ChughK., MalhotraK.C.Spot diagnosis of aluminium phosphide ingestion: an application of a simple test. J Assoc Physicians India1989; 37(3): 219–20.
14.
Vins JansenA., ThraneK.E.Gas chromatographic determination of PH3 in ambient air. Analysis1978; 103: 1195–8.
15.
International Programme on Chemical Safety.Environmental health criteria 73: phosphine and selected metal phosphides.Geneva: World Health Organization; 1998. [cited 2007 Sep 14]. Available from: http://www.who.int/ipcs/publications.
16.
LeeschJ.G.Accuracy of different sampling pumps and detector tube combinations to determine phosphine concentration. J Econ Entomol1982; 75: 899–905.
KatiraR., ElhenceG.P., MehrotraM.L., SrivastavaS.S., MitraA., AgarwalaR.A study of aluminum phosphide (AlP) poisoning with special reference to electrocardiographic changes. J Assoc Physicians India1990; 38(7): 471–3.
21.
SiwachS.B., SinghH., Jagdish, KatyalV.K., BhardwajG.Cardiac arrhythmias in aluminium phosphide poisoning studied by on continuous holter and cardioscopic monitoring. J Assoc Physicians India1998; 46(7): 598–601.
