Scopolamine transdermal patch is a form of anticholinergic drug used to prevent motion sickness. We reported two cases of anticholinergic poisoning resulting from scopolamine transdermal patch. The first case experienced local toxicity and presented with right eye mydriasis for five days. The second case developed systemic anticholinergic toxidrome contributed by the scopolamine patch and presented with acute confusion. She was treated successfully by physostigmine, an anticholinergic antidote. The recommendation on physostigmine use was also discussed. We hope that these two case reports will raise the clinician awareness of the potential side effect of this kind of product.
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