Abstract
Objectives
To investigate the efficacy and safety of oral paracetamol compared with oral non-steroidal anti-inflammatory drugs (NSAIDs) or combination therapy in relieving pain after limb injury in an emergency department.
Design
Double blind, randomised, controlled study.
Setting
Emergency department of a university hospital in the New Territories of Hong Kong.
Subjects
50 adult patients with painful isolated limb injuries.
Main outcome measures
Primary outcome measures were pain relief at rest and with limb movement, and adverse events.
Results
There was no statistical difference in the mean reduction in pain score between oral paracetamol and oral NSAIDs in the first two hours of treatment or over three days. Patients' pain reduced significantly over three days but it was unclear whether this was due to natural healing rather than analgesic medication. There was no significant difference in pain relief between paracetamol and NSAIDs over three days treatment. All combinations appeared to be safe with no major adverse effects reported in the study.
Conclusion
Oral paracetamol may be as effective and as safe as moderate dose of NSAIDs in the management of musculoskeletal pain. A larger study is required to confirm this hypothesis.