The genetic toxicity of non-steroidal anti-inflammatory drugs was investigated using the sister chromatid exchange technique in cultured human lymphocytes. A total of 48 patients were treated with non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac or acetylsalicylic acid) for 2 weeks. The average numbers of sister chromatid exchanges in cultured lymphocytes from the patients, before and after treatment with these drugs, did not differ significantly (P > 0.05). These results indicate that treatment with non-steroidal anti-inflammatory drugs for 2 weeks does not induce sister chromatid exchanges in T lymphocytes.
HofferLThumbN: Anti-inflammatorisch wirksame Substanzen, ihre Workung auf DNA Synthese und Reparatur. In: Klinische Pharmakologie, Vol. 4, (KuemmerleH, ed). Landsberg: Eco-Med Verlag, 1984; pp 1–12.
2.
KleinGWottawaA: Der Einfluss sogenn-anter Basis Therapeutika aut Enzyme der DNA-synthese und DNA-reparatur. Acta Med Austriaca1975; 2: 153–156.
3.
ZimonjicDPopescuNCDePaolaJA: Induction of sister chromatid exchanges by tobacco-specific nitrosamine 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butonone in human and hamster cells. Carcinogenesis1989; 10: 753–755.
4.
BeenPAPerleMA: Chromosome staining and banding techniques. In: Human Cyto-genesis: a Practical Approach (RooneyDEChepulkowskiBH, eds). Oxford: IRL Press, 1987; pp 57–84.
5.
BenedictWFBanerjeeAKangalingamKKDansieDRHenryCJ: Increased sister chromatid exchanges in bone marrow cells of mice exposed to whole cigarette smoke. Mutation Res1984; 136: 73–80.
6.
OzkulYErenmemisogluACucerNMenevseASaatciCA: Sister-chromatid exchange inducing effect of smokeless tobacco using on T-lymphocyte chromosomes. Mutation Res1995; 334 (2): 209, 212.
7.
KullichWKleinG: Investigations of the influence of nonsteroidal antirheumatic drugs on the rates of sister chromatid exchange. Mutation Res1986; 138: 131–134.
8.
SardasSKarakayaASUgurNCengelMMetinA: Sister chromatid exchange in patients treated with nonsteroidal antiinflammatory drugs. Drug Safety1991; 6: 390–392.
9.
KullichWHermanJKleinG: Zytogeneti-sche undesuchungen an humanen Lymphozyten unter den Einfluss von Oxica-men. Z Rheumatol1990; 49: 77–81
