We reported two patients who presented with non-specific chest symptoms with ECG changes mimicking acute myocardial infarction and ventricular hypertrophy. Both of them were finally confirmed to have Wolff-Parkinson-White (WPW) syndrome after spontaneous resolution of the ECG changes. As a matter of fact, other differential diagnosis should be considered with respect to the ST-segment changes. Diagnostic pitfalls can be avoided by detailed analysis of the ECG before commencement of thrombolytic agents.
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