Pneumothorax is one of the most common neonatal emergencies encountered in the Neonatal Intensive Care Unit (NICU), which commonly resolves with conventional treatment methods, such as needle aspiration and intercostal drain (ICD) insertion. Other management strategy includes the application of negative suction when it remains persistent or worsens. The need for negative suction among neonates is very rare, and there are no specific guidelines for its usage till date. This case series highlights the use of negative suction for the management of pneumothorax, which was not resolved by conventional techniques.
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