Penalized estimation of semiparametric transformation models with interval-censored data and application to Alzheimer’s disease

Abstract

Variable selection or feature extraction is fundamental to identify important risk factors from a large number of covariates and has applications in many fields. In particular, its applications in failure time data analysis have been recognized and many methods have been proposed for right-censored data. However, developing relevant methods for variable selection becomes more challenging when one confronts interval censoring that often occurs in practice. In this article, motivated by an Alzheimer’s disease study, we develop a variable selection method for interval-censored data with a general class of semiparametric transformation models. Specifically, a novel penalized expectation–maximization algorithm is developed to maximize the complex penalized likelihood function, which is shown to perform well in the finite-sample situation through a simulation study. The proposed methodology is then applied to the interval-censored data arising from the Alzheimer’s disease study mentioned above.