We document a 30 y old man with Primary Antiphospholipid Syndrome (PAPS) and thrombosis of the common femoral vein and both the external and common iliac veins, extending to the lower vena cava, which failed to respond to high dose heparin. After three days of fibrinolytic treatment with urokinase there was complete venous recanalization.
Harris ENSyndrome of the black swan. Br J Rheumatol1987; 26: 324-326.
2.
Love PE, Santoro SAAntiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders: prevalence and clinical significance. Ann Intern Med1990 ; 112: 682-698.
3.
Alarcón-Segovia D. et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine1989 ; 68: 353-365.
4.
Vivancos J. et al. Sindrome antifosfolipido primario: estudio clínico y biologico de 36 casos. Med Clin (Barc) 1994; 15: 561-565.
5.
Hughes GrvThe antiphospholipid syndrome: ten years ago. Lancet1993; 342: 341-344.
6.
Lockshin MDWhich patients with antiphospholipid antibody should be treated and how?. Rheum Dis Clin North Am1993; 19: 235-247.
7.
Levine SR, Brey RL, Joseph Clm, Havstad S.Risk of recurrent thromboembolic events in patients with focal cerebral ischemia and antiphospholipid antibodies. Stroke1992 ; 23(suppl 1): I-29-I-32.
8.
Khamashta MA et al. The management of thrombosis in the antiphospholipid syndrome. N Engl J Med1995 ;: 993-997.
9.
DerksenRHWM, de Groot PG, Kater L, Nieuwenhuis HK. Patients with antiphospholipid antibodies and venous thrombosis should receive life-long anticoagulant treatment . Ann Rheum Dis1993; 52: 689-692.
10.
Khamashta MA , Wallington T.Management of the antiphospholipid syndrome . Ann Rheum Dis1991; 50: 959-962.
11.
Handin RIAnticoagulant, fibrinolytic, and antiplatelet therapy. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL (eds). Harrison's Principles of Internal Medicine. 13th ed. Vol. 2. New York, McGraw-Hill, 1994; 1810-1813.
