A 63-year-old woman developed a clinical and pathological picture of polyarteritis nodosa (PAN). Systemic lupus erythematosus (SLE) had been diagnosed 12 years previously, and she had been symptom and therapy-free for a decade. Development of 'primary' systemic vasculitis in SLE patients has rarely been described previously and the significance of this association remains unclear. The possible explanation for this transition from one connective tissue disease to another is discussed.
Steinberg ADSystemic lupus erythematosus: theories of pathogenesis and approach to therapy. Clin Immunol Immunopathol1994; 72: 171-176.
2.
D'Cruz D. et al. Systemic lupus erythematosus evolving into systemic vasculitis: a report of five cases. Br J Rheumatol1993 ; 32: 154-157.
3.
Tan EM et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum1982; 25: 1271-1272.
4.
Lightfoot RW et al. The American College of Rheumatology 1990 criteria for the classification of polyarteritis nodosa. Arthritis Rheum1990; 33: 1088-1093.
5.
Kerr GS, Hoffman GSSystemic lupus erythematosus and the cardiovascular system: vasculitis. In: Lahita RG (ed.) Systemic Lupus Erythematosus, 2nd edn. Churchill Livingstone: New York, 1992.
6.
Watson R.Cutaneous lesions in systemic lupus erythematosus. Med Clin North Am1989; 73: 1091.
7.
Callen JP, Kingman J.Cutaneous vasculitis in systemic lupus erythematosus: a poor prognostic indicator . Cutis1983; 32: 433-435.
8.
Bell DASLE in the elderly. Is it really SLE or systemic Sjögren's syndrome? J Rheumatol1988; 15: 723-724.
9.
Alexander ELInflammatory vascular diseases in Sjögren's syndrome. In: Talal N, Moutsopoulos HM , Kassan SS (eds). Sjögren's Syndrome. Clinical and Immunological Aspects. Springer : Berlin, 1987.
10.
Fauci AS, Haynes BF, Katz P.The spectrum of vasculitis. Ann Intern Med1978; 89: 660-676.
