Neonatal lupus erythematosus (NLE) affects 1%–2% pregnant females with autoimmunity. An infant presented with steroid refractory hemolytic anemia as a manifestation of NLE. A trial of withholding breastfeeding had a transient response, but infant was eventually put on cyclosporin therapy to control the hemolysis. Now he is thriving well and transfusion free.
LeeLA. Neonatal lupus: clinical features and management. Paediatr Drug2004; 6: 71–78.
4.
LeeLA. The clinical spectrum of neonatal lupus. Arch Dermatol Res2009; 301: 107–110.
5.
StevensAMHermesHMLambertNCNelsonJLMeroniPLCimazR. Maternal and sibling microchimerism in twins and triplets discordant for neonatal lupus syndrome–congenital heart block. Rheumatology (Oxford)2005; 44: 187–191.
MartinVLeeLAAskanaseADKatholiMBuyonJP. Long-term follow up of children with neonatal lupus and their unaffected siblings. Arthritis Rheum2002; 46: 2377–2383.
CimazRSpenceDLHornbergerLSilvermanED. Incidence and spectrum of neonatal lupus erythematosus: a prospective study of infants born to mothers with anti-Ro autoantibodies. J Pediatr2003; 142: 678–683.
10.
WolachBChocLPomeranzABen AriYDouerDMetzkerA. Aplastic anemia in neonatal lupus erythematosus. Am J Dis Child1993; 147: 941–944.
11.
WatsonRKangJEMayMHudakMKicklerTProvostTT. Thrombocytopenia in the neonatal lupus syndrome. Arch Dermatol1988; 124: 560–563.
12.
AskanaseADMiranda-CarusMETangXKatholiMAABuyonJP. The presence of IgG antibodies reactive with components of the SSA/Ro-SSB/La complex in human breast milk: Implications in neonatal lupus. Arthritis Rheum2002; 46: 269–271.
13.
ReedJHClancyRMPurcellAWKimMYGordonTPBuyonJP. Β2-glycoprotein I and protection from anti-SSA/Ro60-associated cardiac manifestations of neonatal lupus. J Immunol2011; 187: 520–526.
