Cutaneous lupus erythematosus may be related to maternal autoantibody production in the neonatal lupus syndrome, or may occur later in childhood, with or without findings of systemic lupus erythematosus (SLE). In the first section, we will discuss the transient, passively transferred neonatal disease, and in the second, we will discuss the persistent, actively acquired forms of lupus erythematosus in childhood.
Aylward RDCongenital heart-block. Br Med J1928; 1: 943
2.
McCuistion CH , Schoch EP, Jr. Possible discoid lupus erythematosus in newborn infant: Report of a case with subsequent development of acute systemic lupus erythematosus in mother. Arch Dermatol1954; 70: 782-785.
3.
Hogg GRCongenital, acute lupus erythematosus associated with subendocardial fibroelastosis: Report of a case. Am J Clin Path1957; 28: 648-654.
4.
Franco HL et al. Association of antibodies to sicca syndrome antigens in newborns with lupus erythematosus and their mothers. Clin Res1980; 28: 134A (abstract).
5.
Weston WL et al. A serological marker for neonatal lupus erythematosus. Br J Dermatol1982; 107: 377-382.
6.
Lee LA, Weston WLSpecial cosniderations concerning the cutaneous manifestations of rheumatic diseases in children. In: Sontheimer RD, Provost TT (eds). Cutaneous manifestations of Rheumatic Diseases. Williams344
7.
Reed BR et al. Autoantibodies to SS-A/Ro in infants with congenital heart block . J Pediatr1983; 103: 889-891.
8.
Scott JS et al. Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block. N Engl J Med1983 ; 309: 209-212.
9.
Esscher E., Scott JSCongenital heart block and maternal systemic lupus erythematosus. Br Med J1979; 1: 1235-1238.
10.
Press et al. Long-term outcome of mothers of children with complete congenital heart block . Am J Med1996; 100: 328-332.
Waltuck J., Buyon JPAutoantibody-associated congenital heart block: outcome in mothers and children . Ann Intern Med1994; 120: 544-551.
13.
McCune AB, Weston WL, Lee LAMaternal and fetal outcome in neonatal lupus erythematosus. Ann Inter Med1987; 106: 518-523.
14.
Julkunen H. , Kaaja R., Wallgren E., Teramo K.Isolated congenital heart block: fetal and infant outcome and familial incidence of heart block. Obstet Gynecol1003; 82: 11-16.
15.
Ramsey-Goldman R. et al. Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. Arthritis Rheum1986; 29: 1269-1273.
16.
Lockshin MD , Bonfa E., Elkon K., Druzin MLNeonatal lupus risk to newborns of mothers with systemic lupus erythematosus. Arthritis Rheum1988; 31: 697-701.
17.
Lee LANeonatal lupus erythematosus. J Invest Dermatol1993; 100: 9S-13S.
18.
Thornton CM et al. Cutaneous telangiectases in neonatal lupus erythematosus. J Am Acad Dermatol1995 ; 33: 19-25.
McCue CM, Mantakas ME, Tingelstad JB, Ruddy S.Congenital heart block in newborns of mothers with connective tissue disease . Circulation1977; 56: 82-90.
23.
Lev M. et al. Lack of connection between the atria and the more peripheral conduction system in congenital atrioventricular block. Am J Cardiol1971; 27: 481-488.
24.
Ho SY, Esscher E., Anderson RH, Michaëlsson M.Anatomy of congenital complete heart block and relation to maternal anti-Ro antibodies. Am J Cardiol1986; 58: 291-294.
25.
Franco HL et al. Autoantibodies directed against sicca syndrome antigens in the neonatal lupus syndrome. JAm Acad Dermatol1981; 4: 67-72.
26.
Laxer RM et al. Liver disease in neonatal lupus erythematosus. J Pediatr1990; 116: 238-242.
27.
Lee LA, Reichlin M., Ruyle SZ, Weston WLNeonatal lupus liver disease. Lupus1993; 2: 333-338.
28.
Watson R. et al. Thrombocytopenia in the neonatal lupus syndrome. Arch Dermatol1988; 124: 560-563.
David-Bajar et al. Clinical, histologic, and immunofluorescent distinctions between subacute cutaneous lupus erythematosus and discoid lupus erythematosus. J Invest Dermatol1992; 99: 251-257.
31.
Lee LA et al. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. J Clin Invest1989; 83: 1556-1562.
32.
Provost TT et al. The neonatal lupus syndrome associated with U1RNP (NRNP) antibodies . New Engl J Med1987; 316: 1135-1138.
33.
Maddison PJ et al. Anti-p57: a novel association with neonatal lupus. Clin Exp Immunol1995; 99: 42-48.
34.
Lee LA, Frank MB, McCubbin VR, Reichlin M.The autoantibodies of neonatal lupus erythematosus. J Invest Dermatol1994; 102: 963-966.
35.
McCauliffe DP, Sontheimer RDMolecular characterization of the Ro/ SS-A autoantigens. J Invest Dermatol1993; 100: 73S-79S.
36.
Sontheimer RD et al. Clinical correlations of autoantibodies to a recombinant, hYRNA-binding form of human calreticulin. J Invest Dermatol1996; 106: 938 (abstract).
37.
Cheng S-T. et al. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro-SS-A ribonucleoprotein autoantigen. J Immunol1996; 156: 4484-4491.
38.
Lee LAMaternal autoantibodies and pregnancy-II: The neonatal lupus syndrome. BaillieresClin Rheumatol1990; 4: 69-84.
39.
Provost TT, Watson R.Anti-Ro(SS-A) HLA-DR3-positive women: The interrelationship between some ANA negative, SS, SCLE, and NLE mothers and SS/LE overlap female patients. J Invest Dermatol1993; 100: 14S-20S.
40.
Lee LA, Coulter S., Erner S., Chu H.Cardiac immunoglobulin deposition in c ongenital heart block associated with maternal anti-Ro autoantibodies. Am J Med1987; 83: 793-796.
41.
Reichlin M. et al. Concentration of autoantibodies to native 60 kd Ro/ SS-A and denatured 52 kd Ro/SS-A in eluates from the heart of a child who died with congenital complete heart block. Arthritis Rheum1994; 37: 1698-1703.
42.
Alexander E. , Buyon JP, Provost TT, Guarnieri T.Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. In vitro electrophysiologic and immunocytochemical studies. Arthritis Rheum1992; 35: 176-189.
43.
Garcia et al. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts. J Clin Invest1994 ; 93: 718-724.
44.
Bennion et al. IgG subclasses in the serum and skin in subacute cutaneous lupus erythematosus and neonatal lupus erythematosus. J Invest Dermatol1990; 95(6): 643-646.
45.
Lee LA, Alvarez K., Gross T., Harley JBThe recognition of human 60 kD Ro ribonucleoprotein particles by antibodies associated with cutaneous lupus and neonatal lupus. J Invest Dermatol1996; 107: 225-228.
46.
Lee LA et al. Immunogenetics of the neonatal lupus syndrome. Ann Intern Med1983; 99: 592-596.
47.
Watson RM et al. Neonatal lupus erythematosus syndrome: analysis of C4 allotypes and C4 genes in 18 families. Medicine1992 ; 71: 84-95.
Meyer O., Hauptmann G., Tappeiner G., Ochs HD, Mascart-Lemone F.Genetic deficiency of C4, C2 or C I q and lupus syndromes. Association with anti-Ro (SS-A) antibodies. Clin Exp Immunol1985; 62: 678-684.
53.
Taieb et al. Lupus erythematosus panniculitis with partial genetic deficiency of C2 and C4 in a child. Arch Dermatol1986; 122: 576-582.
54.
Kettler AH, Bean SF, Duffy JO, Gammon WRSystemic lupus erythematosus presenting as a bullous eruption in a child. Arch Dermatol1988 ; 124: 1083-1087.
