We present a 16-year old girl with Prader-Willi syndrome who developed cardiac tamponade as an initial finding of systemic lupus erythematosus. Until one year prior to this episode, she had received growth hormone treatment for nine years. The association among Prader-Willi syndrome, growth hormone treatment and systemic lupus erythematosus is discussed. Lupus (2007) 16, 447—449.
Goldstone APPrader-Willi syndrome: advances in genetics, pathophysiology and treatment. Trends Endocrinol Metab2004; 15: 12—20.
2.
Doherty NE, Siegel RJCardiovascular manifestations of systemic lupus erythematosus. Am Heart J1985; 110: 1257—1265.
3.
Kahl LEThe spectrum of pericardial tamponade in systemic lupus erythematosus: Report of ten patients. Arthritis Rheum1992; 35: 1343—1349.
4.
Gulati S., Kumar L.Cardiac tamponade as an initial manifestation of systemic lupus erythematosus in early childhood. Ann Rheum Dis1992; 51: 279—280.
5.
Lerer RJCardiac tamponade as an initial finding in systemic lupus erythematosus. Am J Dis Child1972; 124: 436—437.
6.
Tamura A., Agematsu R., Urasawa R., Naganuma K., Komiyama A.Cardiac tamponade due to systemic lupus erythematosus in a 7-year-old boy with selective IgG subclass deficiency. Eur J Pediatr1998; 157: 475—478.
7.
Rivero S., Jacobelli S.Hypothalamic-pituitary-adrenal axis function and prolactin secretion in systematic lupus erythematosus. Lupus1998; 7: 404—408.
8.
Dixit VD, Schaffer EM, Pyle RS et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest2004; 114: 57—66.
9.
Cummings DE, Clement K., Purnell JQ et al. Elevated plasma ghrelin levels in Prader-Willi syndrome. Nat Med2002; 8: 643—644.
10.
de Mello-Coelho V., Gagnerault MC, Souberbielle JC et al. Growth hormone and its receptor are expressed in human thymic cells. Endocrinology1998; 139: 3837—3842.
11.
Poster-Vinay MC, de Mello Coelho V., Gagnerault MC, Dardenne M.Growth hormone stimulates the proliferation of activated mouse T lymphocytes. Endocrinology1997; 138: 16—20.
12.
Bae YS, Bae SC, Lee SW,Yoo DH, Kim TY, Kim SYLupus flare associated with growth hormone. Lupus2001; 10: 448—450.
13.
Yap HK, Loke KY, Murugasu B., Lee BWSubclinical activation of lupus nephritis by recombinant human growth hormone . Pediatr Nephrol1998; 12: 133—135.
14.
Ogueta S., Olazabal I., Santos I., Delgado-Baeza E., Garcia-Ruiz JPTransgenic mice expressing bovine GH develop arthritic disorder and self-antibodies . J Endocrinol2000; 165: 321—328.
