Proceedings of the British Toxicology Society Autumn Meeting University of York 20-22 September 1998

Lazarou, J. , Pomeranz, B. H. & Corey, P. N. (1998) JAMA, 279, 1200-1295 .

Pinnohamed, M. , Kitteringham, N. R. , Breckenridge, A. & Park, B. K. (1998) Brit. Med. J. 316, 1295-1298

Park, B. K. , Pirmohamed, M. & Kitteringham, N. R. (1998) Chem. Res. Toxicol., in press

London, S. J. , Daly, A. K. , Cooper, J. , Navidi, W. C. , Carpenter, C. L. & Idle, J. R. (1995) J Natl Cancer Inst 87, 1246-1253 .

Welfare, M. R. , Cooper, J. , Bassendine, M. F. & Daly, A. K. (1997) Carcinogenesis 18, 1351-1354 .

Johansson, I. , Bertilsson, L. , Dahl, M-L , Sjöqvist, F and Ingelman-Sundberg, M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine . Proc Natl Acad Sci (USA), 1993, 90: 11825-11829 .

Aklillu, E. , Persson, I. , Bertilsson, L. , Johansson, I. , Rodrigues, F and Ingelman-Sundberg, M. : Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiplicated functional CYP2D6 alleles . J. Pharm Exp Ther, 1996, 278: 441-446 .

McLellan, R. , Oscarson, M. , Alexandrie, A.-K. , Seidegard, J. , Evans, D. A. P. , Rannug, A. and Ingelman-Sundberg, M. : Characterization of a human glutathione S-transferase mu cluster containing a duplicated GSTM/ gene causing ultrarapid enzyme activity . Mol Pharmacol 1997, 52: 958-965 .

Lindahl, T. , P. Karran & Wood, R. D. (1997) Current Opinion in Genetics & Development 7, 158-169

Martin, U. & George, C. F. (1998) In Drug Therapy in Old Age ed. George et al. U.K. pp 73-86. Chichester: Wiley

Ford, G. A. , Hoffman, B. B. & Blaschkc, T.F (1998) In Drug Therapy in Old Age ed George et al. U.K. pp 59-72. Chichester: Wiley

Thomas, S. H. L. , Higham, P. D. , Hartigan-Go. K. , Kamali, F. , Wood. P. , Campbell. R. F. W. & Ford, G. A. (1995) Br Heart J 74, 53-56

Waxman, D. J. & Azaroff, L. (1992) Biochem. J. 281, 577-582

Bars, R. G. , Bell, D. R. , Elcombe, C. R. , Oinonen, T. , Jalava, T. , Lindros, K. L. (1992) Biochem. J. 282, 635-638

Stoltz, C. , Vachon, M. , Trottier, E. , Dubrois, S. , Paquet, Y. & Anderson, A. (1998) J. Biol. Chem. 273, 8528-8536

Mangelsdorf, D. J. , et al. Cell 83, 835-839 (1995).

Tora, L. , et al. Cell 59, 477-487 (1989).

Glass, C. K. , Rose, D. W. & Rosenfeld, M. G. Current Opinion in Cell Biology 9, 222-232 (1997).

Lazennec, G. , Ediger, T. R. , Petz, L. N. , Nardulli, A. M. & Katzenellenbogen, B. S. Molecular Endocrinology 11, 1375-1386 (1997).

Onate, S. A. , et al. Journal of Biological Chemistry 273, 12101-12108 (1998).

Onate, S. A. , Tsai, S. Y. , Tsai, M. J. & Omalley, B. W. Science 270, 1354-1357 (1995).

Nordic Council of Ministers., (1996). In: Naturally Occurring Antitumourigens-III. Indoles, pp 29-39. Tema Nord: 535

Wakabayashi, K. , et al. , (1985) Mut. Res. 143, 17-21

Yamashita, K. , et al. , (1988) Carcinogenesis, 9, 1905-1907

Cragg, GM , Newman, DJ & Snader, KM (1997) J. Nat. Prod. 60, 52-60

Kaisin, M , Braekman, JC , Daloze D & Tursch, B (1985) Tetrahedron 41, 1067-1072

Mossman, T (1983) J. Immunol. Meth. 65, 55-63

Tettey J. N. A. , Grant, M. H. , Midgley, J. M. , Skellern, G. G. & Wilkinson, R. (1997) Br. J. Clin. Pharmacol. 43 (2), 215-216 .

MacDonald C. , Vass M. , Willett B. , Scott A. & Grant M. H. (1994) Human & Experimental Toxicology 13, 439-444 .

Anderson K. , Yin L. , MacDonald C. (1996) Toxicology In Vitro 10, 721-727 .

Lasker, J. M. , Raucy, J. , Kubota S. , Blosiwck, B. P. , Black, M. , & Lieber, C. S. (1987) Biochem Biophys Res Comm 148, 232-238

Ingelman-Sundberg, M. , Johansson, I. , Yin, H. , Terelius Y. , Eliasson, E. , Clot, P. , & Albane, E. (1993) Alcohol 10, 447-452

McGuigan, L. A. , Hawksworth, G. M. , Murray, G. I. , Ewan S. W. B. , Whiting, P. H. & Brunt, P. W. (1996) Gut 38, F221-F221

Weltman, M. D. , Farrell, G. C. , Hall, P. , Ingelman-Sundberg, M & Liddle, C. (1998) Hepatology 27, 128-133

Minchin, R. F. (1995) Acetylation of p-aminobenzoylglutamate, a folic acid catabolic, by recombinant human N-acetytransferase and U937 cells . Biochem. J. 307, 1-3

Goulding, M. , Sterrer, S. Fleming, J. , Balling, R. , Nadeau, J. , Moore, K. J. , Brown, S. D. M. , Stell, K. P. and Gruss, P. (1993) Analysis of the Pax3 gene in the mouse mutant Splotch . Genomics 17, 355-363 .

Robertson, D. W. , Leander, J. D. , Lawson, R. , Beedle, E. E. , Clark, C. R. Potts, B. D. and Parli, C. J. (1987) Discovery and anticonvulsant activity of the potent metabolic inhibitor 4-amino-N-(2,6-dimethylphenyl)-3,5-dimethylbenzamide . J. Med. Chem. 30, 1742-1746 .

Wand, A. , Hickman, D. , Gordon, J. W. and Sim, E. (1992) Arylamine N-acetyltransferase in human red blood cells . Biochem. Pharm. 44, 1099-1104 .

Nicholson, J. K. and Wilson, I. D. , (1989) Prog NMR Spectrosc 21: 444-501 .

Beekwith-Hall, B. M. , Nicholson, J. K. , Nicholls, A. W. , Foxall, P. D. F. , Lindon, J. C. , Connor, S. C. , Abdi, M. , Connelly, J. and Holmes E. (1998) Chem Res Toxicol 11: 260-272 .

Wold, S. , (1976) Pattern Recognition 8 127-139 .

Holmes, E. Caddick, S. Lindon, J. C. , Wilson I. D. Kryvawych, S. and Nicholson, J. K. (1995) Biochemical Pharmacology 49(10): 1349-1359 .

Waterfield, C. J. , Turton, J. A. Scales, D. and Timbrell, J. A. (1993) Arch. Toxicol. 67: 244-254 .

Tomlins. A. Foxall, P. J. D. , Lynch. M. Lindon, J. C. and Nicholson, J. K. (1998) Anal. Com. 35: 113-113 .

Young (1981) Fundamental and Applied Toxicology, 1, 309-312

Yallop, D. , Andrews, M. , Holt, D. , York, M. , Fagg, R. , Williams, T. & Turton, J. (1998) Hum. Exp. Toxicol. 17, 57-57

Holt, D. , Andrews, C. , Payne, J. , Williams, T. & Turton, J. (1998) Hum. Exp. Toxicol. 17, 8-17

Philpott, N. , Turner, A. , Scopes, J. , Westby, M. , Marsh, J. , Gordon-Smith, E. , Dalgleish, A. & Gibson, F. (1996) Blood 87, 2244-2251

Mutch E , Blain PG , Williams FM (1997). Hum Exp Toxicol 16: 409-409 .

Davies HG et al , (1996). Nature Genet 14: 334-336 .

Garle, M. J. , Fry, J. R. (1989) Toxicology, 54 101-110 .

Hissin, P. J. , Hilf, R. (1976). Analytical Biochemistry. 74, 214-226 .

Lowry, D. H. , Rosebrough, N. J. , Farr, A. L. , Randall, R. J. (1951), Journal of Biological Chemistry, 193, 265-275 .