Distribution of nickel in body fluids and organs of rats chronically exposed to nickel sulphate

Abstract

1 Male and female rats were given 100 mg Ni L-1 (as nick el sulphate) in drinking water for 6 months.

2 The feeding of nickel was associated with an increased concentration of nickel in body fluids and organs. The highest concentrations of nickel were found in the liver of both male and female rats. In male rats nickel levels decreased in the order: liver > kidney = whole blood = serum > testes > urine. In female rats the decreasing order was similar: liver > kidney = whole blood = serum = plasma > urine > ovaries.

3 No significant differences were found between nickel concentrations in organs (except ovaries), blood and urine of rats exposed for 3 months and those exposed for 6 months indicating the reaching of a steady state of nickel in the rat during long-term exposure.

4 The urinary excretion of the orally administered nickel was only 2% of absorbed dose (supposing 1% Ni absorp tion).

Keywords

nickel body fluids organs rats

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References

World Health Organization. Nickel Environmental Health Criteria 108. Geneva: WHO, 1991.

Schroeder HA , Mitchener M. , Nason AP Life-term effects of nickel in rats: Survival, tumours, interactions with trace elements and tissue levels. J Nutrit 1974; 104: 239-243.

Phatak SS , Pathawardhan, VN Toxicity of nickel — accumulation of nickel in rats fed on nickel-containing diets and its elimination. J Sci Ind Res 1952 ; 11B: 173-176.

Vyskocil A. , Viau, C. , Cizkova M. Chronic nephrotoxicity of soluble nickel in rats. Hum Exp Toxicol 1994; 13: 689-693.

Mader P. et al. Comparison of the determination of lead and cadmium in animal tissues using the methods of atomic absorption spectrometry and differential pulse anodic stripping voltametry. Chem Listy 1987; 81: 1190-1198.

Severa J. , Cizkova M. , Petrovicka B. Modificated method of dry decomposition of samples of biological material . Acta Hyg Epidemiol Microbiol 1994; 23: 1-3.

Nieborer, E. , Sanford, WE , Stace BC Absorption, distribution, and excretion of nickel. In Nieborer E, Nriagu JO. Nickel and Human Health. New York: John Wiley and Sons, 1992; pp. 49-68.

Huang et al. The distribution of trace elements in rats. Acta Zool Sin 1986; 32: 35-39.

Medinsky MA , Benson JM , Hobbs CH Lung clearance and disposition of 63Ni in F344/N rats after intratracheal instillation of nickel sulphate solutions. Environ Res 1987; 43: 168-178.

10.

Anke M. , Grun M. , Kronemann H. Distribution of nickel in nickel-deficient goats and their offspring. In: Brown SS, Sunderman Jr FW. Nickel Toxicology. London: Academic Press, 1980; pp. 69-72.

11.

Whanger PD Effects of dietary nickel on enzyme activities and mineral contents in rats . Toxicol Appl Pharmacol 1973; 25: 323- 331.

12.

Norseth T. Nickel . In: Friberg L, Nordberg, GF, Vouk VB. Handbook on the Toxicology of Metals. Vol II: Specific Metals. Amsterdam: Elsevier, 1986; pp. 465-481.

13.

Nielsen FH Interaction of nickel with essential minerals. In: Nriagu JO. Nickel in the Environment. New York, John Wiley and Sons, 1980, pp. 611-634.