Peroxisomes without catalase: More evidence for the active oxygen hypothesis?

Abstract

Get full access to this article

View all access options for this article.

References

DeDuve C. , Baudhuin P. Peroxisomes (microbodies related particles). Physiol Rev 1966; 46 : 323-357.

Litwin JA , Fahimi HD Retrospective immunocytochemical demonstration of peroxisomal enzymes in human liver biopsies processed conventionally for light and electron microscopy . Peroxisomes in Biology and Medicine . HD Fahimi, H Sies (eds), Springer-Verlag: Berlin, Heidleberg, 1987; pp.379-384.

Novikoff AB , Goldfischer S. Visualisation of peroxisomes (microbodies) and mitochondria with diaminobenzidine . J Histochem Cytochem 1969; 17: 675-680.

Reddy JK , Rao JJ Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mut Res 1989 ; 214: 63-68.

Santos MJ et al. Characterisation of human peroxisomal membrane proteins. J Biol Chem 1994; 269: 24890-24896.

Floyd RA Role of oxygen free radicals in carcinogenesis and brain ischaemia . Faseb J 1990; 4: 2587-2597.

Frenkel K. Carcinogen mediated oxidant formation and oxidative damage. Pharmacol Ther 1992; 53 : 127-166.

Soames AR , Foster JR Juxtaposition of peroxisomes and chromosomes in mitotic hepatocytes following methyl clofenapate administration to rats. Int J Exp Path 1995; 75 : 405-414.

Reddy JK et al. Excessive accumulation of autofluorescent lipofuscin in the liver during hepatocarcinogenesis by methyl clofenapate and other hypolipidaemic peroxisome proliferators. Can Res 1982; 42: 259-266.

10.

Solt D. , Medline A. , Farber E. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol 1977; 88 : 595-610.