A 34-year-old man suffered from fulminant hepatitis after cleaning a tank in which there were traces of dichlorohydrin. In spite of daily plasma exchanges, he died 10 days after exposure. A 27-year-old man with much lighter exposure showed only slight liver dysfunction. This is the first report of lethal injury following exposure to dichlorohydrin.
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References
1.
Sax NI, Lewis RJ 1,3-Dichloro-2-propanol. In Dangerous Properties of Industrial Materials, 7th ed. New York: Van Nostrand Reinhold Co., 1989, pp. 1173-4.
2.
Hahn H., Eder E. & Deininger C.Genotoxicity of 1,3-dichloro-2-propanol in the SOS chromotest and in the AMES test. Elucidation of the genotoxic mechanism. Chemical Biological Interactions1991; 80: 73-88.
3.
Iwasa T., Abe T., Hiramatsu K. et al. Fulminant hepatitis after the inhalation of dichloropropanols . The Journal of University of Occupational and Environmental Health (Japan)1992; 14: 67-71.
4.
Finkel AJChlorinated hydrocarbons. In Hamilton and Hardy's Industrial Toxicology, 4th ed. Boston, John Wright PSG Inc.1983, pp. 225-40.
5.
Hine C., Rowe VK, White ER et al. In Patty's Industrial Hygiene and Toxicology, 3rd ed., vol2A. New York, Wiley-Interscience, 1981 , pp. 2242-7.
6.
Lawrence HK & Douglas BWCompendium of Safety Data Sheets for Research and Industrial Chemicals. Florida , VCH Publishers Inc., 1985, pp. 798-9.
7.
Gerhartz W (ed). Chlorohydrins. Ullmann's Encyclopedia of Industrial Chemistry, 5th ed., vol A6. New York, VCH, 1986, pp. 565-74.
8.
Sitting M. Dichloropropanols .In Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2nd ed. Park Ridge, Noyes Publ, 1985, pp. 330-1.
9.
Plunkett ERDichlorohydrin. Handbook of Industrial Toxicology, 3rd ed. Victoria (Australia), Edward Arnold Pty Ltd, 1987, pp. 182.
10.
Bretherick L.Hazards in the Chemical Laboratory, 4th ed. London, The Royal Society of Chemistry, 1986, pp. 285.
11.
Matthew JE & Donald GBCarbon Tetrachloride. In Medical Toxicology. Diagnosis and Treatment of Humane Poisoning. New York, Elsevier Science Publishing Company, 1988, pp. 969-72.
12.
Ruprah M., Mant Tgk & Flanagan RJAcute carbon tetrachloride poisoning in 19 patients. Implications for diagnosis and treatment. Lancet1985; i: 1027-9.
13.
Fogel RP, Davidman M., Poleski MH & Spanier AHCarbon tetrachloride poisoning treated with hemodialysis and total parenteral nutrition. Canadian Medical Association Journal1983; 128: 560-1.
