The Plasma Mobilizing Index parameters of the newly synthesized chelating agent THP-12-ane N4, determined by computer simulation studies, have indicated that this chelating agent might be a good antagonist for cadmium intoxication. Experiments conducted on rats confirmed this observation and showed that THP-12-ane N4 might have the ability to chelate and mobilize cadmium in vivo.
Get full access to this article
View all access options for this article.
References
1.
Hancock RDMacrocycles and their selectivity for metal ions on the basis of size. Pure and AppliedChemistry1986; 58: 1445-52.
2.
Hancock RD, Shaikjee MS, Dobson SM & Boeyens Jca.The stereochemical activity or non-activity of the inert pair of electrons on Pb2+ lead II in relation to its complex stability and structural properties . Some considerations in ligand design. Inorganica Chimica Acta1988; 154: 229-38.
3.
May PM & Williams DRComputer simulation of chelation therapy, plasma mobilizing index as a replacement for effective stability constant. FEBS Letters1977; 78: 134-8.
4.
Jones DC, Smith GL, May PM & Williams DRAssessment of pharmaceutical agents for removing cadmium from humans using chemical speciation models. Inorganica Chimica Acta1984; 93: 93-100.
5.
Duffield JR, May PM & Williams DRComputer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminocarboxylic acids. Journal ofInorganic Biochemistry1984 ; 20: 199-214.
6.
Cole A., Furnival C., Huang ZX, Jones DC, May PM, Smith GL, Whittaker J. & Williams DRComputer simulation models for the low-molecular weight complex distribution of cadmium II and nickel II in human blood plasma. Inorganica Chimica Acta1985; 108: 165-71.
7.
Berthon G., Hacht B., Blais MJ & May PMCopper histidine ternary complex equilibria with glutamine, asparagine and serine. The implication for computer simulated distribution of copper II in blood plasma. Inorganica Chimica Acta1986 ; 125: 219-27.
8.
Ames BN, McCann J. & Yamasaki E.Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Research1975; 31: 347-64.
9.
May PM, Linder PW & Williams DRAmbivalent effect of protein binding on computed distribution of metal ions complexed by ligands in blood plasma. Experientia1976; 32: 1492-4.
10.
May PM, Linder PW & Williams DRComputer simulation of metal ion equilibria in biofluids:models for the low molecular-weight complex distribution of Ca2+, Mg2+, Mn2+, Fe3+, Cu2+, Zn2+ and Pb2+ ions in human blood plasma. Journal of the Chemical Society (Dalton Transactions)1977; 6: 588-95.
11.
SAS/STAT User's Guide Release 6.03 ed. 1988. SAS Inst. Inc., Cary NC pp. 597-8.
12.
Jones MM & May PMThe effect of kinetic factors on the thermodynamic evaluation of therapeutic chelating agents. Inorganica Chimica Acta1987; 138: 67-73.
13.
Basinger MA , Jones MM, Hoscher MA & Vaughn WKAntagonists for acute oral cadmium chloride intoxication. Journal of Toxicology and Environmental Health1988; 23: 77-89
14.
Andersen O.Oral cadmium exposure in mice: Toxicokinetics and efficiency of chelating agents. Toxicology1989; 20: 83-112.
15.
Jones MM & Cherian MGThe search for chelate antagonists for chronic intoxication. Toxicology1990; 62: 1-25.
