Sage Journals: Discover world-class research

Abstract

The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats.

The d-propoxyphene (19 mg kg^-1 h^-1) was continously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 ?g kg^-1 min^-1 or 25 ?g kg^-1 min^-1), dobutamine (25 ?g kg^-1 min^-1 or 45 ?g kg^-1min^-1) or normal saline (control). Each group consisted of eight rats.

The myocardial d-propoxyphene content was significantly lower in the two groups given dopamine and in the group given dobutamine 45 ?g kg^-1 min^-1 than in the control group (P < 0.05).

This finding indicates the benefit of early sympathomimetic intervention with either dopamine or dobutamine in d-propoxyphene intoxication.

Get full access to this article

View all access options for this article.

References

Sloth Madsen P. , Strøm J. , Reiz S. & Bredgaard Sørensen M. Acute self-poisoning in 222 consecutive patients. Acta Anaesthesiology Scandinavia 1984; 28: 661-5.

Strøm J. , Häggmark S. , Nyhman H. et al. The effects of dopamine on central hemodynamics and myocardial metabolism in experimental propoxyphene induced shock. Acta Anaesthesiology Scandinavia 1985; 29: 643-50.

Krantz T. , Thisted B. , Strøm J. , Angelo H. & Bredgaard Sørensen M. Severe acute propoxyphene overdose: plasma concentrations of propoxyphene and norpropoxyphene and the effect of dopamine on circulatory failure. Acuta Anaesthesiology Scandinavia 1986; 30: 271-6.

Häggmark S. , Strøm J. , Nyhman H. et al. Effects of prenalterol on central hemodynamics ans myocardial metabolism in experimental propoxyphene induced shock. Acta Anaesthesiology Scandinavia 1987; 31: 52-6.

Angelo HR , Krants T. , Strøm J. , Thisted B. & Bredgaard Sørensen M. High-performance of dextroproxyphene and nordextropropoxyphene in serum. Journal of Chromatography 1985; 345: 413-18.

Angelo HR , Krantz T. , Strøm J. , Thisted B. & Bredgaad Sørensen M. Dextropropoxyphene intoxications: determination of dextropropoxyphene and nordextropropoxyphene in serum and tissues. Acta Pharmacologica Toxicologica 1986, 59: 674.

Emmerson JL , Gibson WR & Anderson RC Acute toxicity of propoxyphene salts. Toxicology and Applied Pharmacology 1971; 19: 445-51.

McMahon RE , Ridolfo AS , Culp HW , Wolen RL & Marshall FJ Fate of radiocarbon-labelled propoxyphere in rat, dog and human. Toxicology and Applied Pharmacology 1971; 19: 427-44.

Emmerson JL , Welles S. & Anderson RC Studies on the tissue distribution of d-propoxyphene. Toxicology and Applied Pharmacology 1967; 11: 482-88.

10.

Gram LF , Schou J. , Way WL , Heltberg J. & Bodin NO d-propoxyphene kinetics after single oral and intravenous doses. Clinical Pharmacology and Therapeutics 1979; 26: 473-82.

11.

Bredgaard Sørensen M. , Häggmark S. , Nyhman H. et al. Circulatory shock following intravenous propoxyphene poisoning. An experimental study of cardiac function and metabolism in pentobarbital anaesthetized pigs. Acta Anaesthesiology Scandinavia 1985; 29: 130-6.

12.

Wright CB , Lamoy RE & Hobson RW Hemodynamic effect of intra-arterial injection of drugs of abuse. Surgery 1976; 79: 425-31.

Dopamine and Dobutamine Reduce Myocardial d-Propoxyphene Content in Experimentally Intoxicated Rats

Abstract

Get full access to this article

References