The pharmacokinetics of intravenously injected potassium cyanide have been studied in Beagle bitches. In the period up to about 80 min after dosing, blood levels fell in a manner consistent with first-order elimination kinetics. Thereafter blood cyanide concentrations fell at a slower rate, indicating that a second phase of slower elimination had been entered.
Get full access to this article
View all access options for this article.
References
1.
Rtecs (1981- 1982). Registry of Toxic Effects of Chemical Substances XL 2275000 . Thiocyanic Acid, Sodium Salt, vol 3, eds, RL Tatkin & RJ Lewis, p 744, National Institute of Occupational Health and Safety.
2.
Ballantyne B.Toxicology of cyanides. In Clinical and Experimental Toxicology of Cyanides, eds B Ballantyne & TC Marrs pp. 41-126. Bristol: John Wright, 1987.
3.
Boxer GE & Rickards JCStudies on the metabolism of the carbon of cyanide and thiocyanate . Archives of Biochemistry and Biophysics, 1952; 39: 7-26.
4.
Smith Adm.Retrobulbar neuritis in Addisonian pernicious anaemia, Lancet1961; i: 1001-2.
5.
Vesey CJNitroprusside cyanogenesis. In Clinical and Experimental Toxicology of Cyanides, eds B. Ballantyne & TC Marrs, pp. 184-208. Bristol : John Wright, 1987.
6.
Schulz V., Gross R., Pasch T., Busse J. & Loeschcke G.Cyanide toxicity of sodium nitroprusside in therapeutic use with and without sodium thiosulphate. Klinische Wochenschrift1982; 60: 1393-400.
7.
McNamara BPEstimates of the toxicity of hydrocyanic acid vapors in man. Edgewood Arsenal Technical Report, No EB-TR-76023, 1976.
Christel D. , Eyer P., Hegeman M., Kiese M., Lörcher W. & Weger N.Pharmacokinetics of cyanide in poisoning of dogs and the effect of 4-dimethylaminophenol or thiosulfate, Archives of Toxicology1977 ; 38: 177-89.
11.
Marrs TC, Bright JE & Swanston DWThe effect of prior treatment with 4-dimethylaminophenol (DMAP) on animals experimentally poisoned with hydrogen cyanide. Archives of Toxicology1982; 51: 247-53.
12.
Marrs TC, Swanston DW & Bright JE4-Dimethylaminophenol and dicobalt edetate (Kelocyanor) in the treatment of experimental cyanide poisoning, Human Toxicology1985; 4: 591-600.
13.
Sylvester DM , Hayton WL, Morgan RL & Way JLEffects of thiosulfate on cyanide pharmacokinetics in dogs, Toxicology and Applied Pharmacology1983; 69: 265-71.
14.
Marrs TC &Bright JEEffect on blood and plasma cyanide levels and on methaemoglobin levels of cyanide administered with and without previous protection using PAPP. Human Toxicology1987 ; 6: 139-45.
15.
Epstein J.Estimation of microquantities of cyanide. Analytical Chemistry1947; 19: 272-4.
16.
Feldstein M. & Klendshoj NCThe determination of cyanide in biologic fluids by microdiffusion analysis. Journal of Laboratory and Clinical Chemistry1954; 44: 166-70.
