Meptazinol is one of the new powerful opioid analgesic agents, and an oral formulation has recently been marketed. Clinically significant respiratory depression is said to be absent1 and no overdoses from meptazinol have been reported in the literature. We report a patient who had a respiratory arrest following an overdose of meptazinol.
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References
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Franklin RA , Aldridge A. & White C de B.Studies on the metabolism of meptazinol, a new analgesic drug. British Journal of Clinical Pharmacology1976; 3: 497-502.
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Ali NA , Marshall RW, Allen EM, Graham DF & Richens A.Comparison of the effects of therapeutic doses of meptazinol and a dextropropoxyphene/paracetamol mixture above and in combination with ethanol on ventilatory function and saccidic eye movements. British Journal of Clinical Pharmacology1978; 20: 631-7.
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Hardy Daj.Meptazinol and respiratory depression . Lancet1983; ii: 576.
