1 A patient ingested about 5 g of orphenadrine hydrochloride. He had gastric lavage and oral administration of activated charcoal. The main symptoms were neuropsychiatric in nature.
2 Possible relation between serum levels of the drug and time course of the toxic effects are described.
Get full access to this article
View all access options for this article.
References
1.
Bennet, M.B. & Kohn, J. (1976). Case report: orphenadrine overdose. Cerebral manifestations treated with physostigmine. Anaesth. Intensive Care, 4, 67.
2.
Deceuninck, F., Silberman, R.M. & Veltman, J.G.J. (1973). A patient with psychosis following orphenadrine poisoning. Ned. Tijdschr. Geneesk. , 117, 25-27.
3.
Labout, J.J.M., Thijssen, C.T., Keijser, G.G. & Hespe, W. (1982). Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man. Eur. J. Clin. Pharmacol. , 21, 343-350.
4.
Millar, W.M. (1977). Deaths after overdoses of orphenadrine. Lancet, ii, 566.
5.
Rutigliano, G. & Labout, J.J.M. (1982). The bioavailability of orphenadrine hydrochloride after intramuscular and oral administration. J. Int. Med. Res., 10, 447-450.
6.
Sangster, B., Van Heijst, A.N.P. & Zimmerman, A.N.E. (1977). Treatment of orphenadrine overdose. N. Engl. J. Med., 296, 1006.
7.
Sangster, B., Van Heijst, A.N.P. & Zimmerman, A.N.E. (1978). Vergiftiging door orphenadrine (Disipal). Ned. Tijdschr. Geneesk., 122, 988-992.
8.
Snyder, B.D., Kane, M. & Plocher, D. (1976). Orphenadrine overdose treated with physostigmine . N. Engl. J. Med., 295, 1435.
9.
Suckow, R.F. & Cooper, T.B. (1982). Simultaneous determination of amitriptyline, nortriptyline and their respective isomeric 10-hydroxy metabolites in plasma by liquid chromatography . J. Chromatogr., 230, 391-400.
