3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity – molecular mechanisms and lessons for pharmacotoxicity

1 Thum T  Borlak J  . Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes. Arch Toxicol 2008; 82: 89–101.

2 Waring JF  Liguori MJ  Luyendyk JP  Maddox JF  Ganey PE  Stachlewitz RF  . Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther 2006; 316: 1080–1087.

3 Liguori MJ  Anderson MG  Bukofzer S  McKim J  Pregenzer JF  Retief J  . Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin. Hepatology 2005; 41: 177–186.

4 Meier T;  Reymann S;  Niehof M;  Borlak J;  . Unraveling trovafloxacins molecular basis of hepatotoxicity (submitted).