Trigeminal (ocular and nasal) irritation comprises the dominant symptom complex in so-called ‘problem buildings’. Imputed etiologic agents in indoor air include extremes of temperature and humidity, the presence of volatile organic compounds, combustion products (including tobacco smoke), ozone (from office machines), and products of indoor air chemistry. In addition to producing primary irritation, mucosal irritants trigger a variety of secondary reflex symptoms, such as nasal congestion, rhinorrhea, and sinus pressure, and may predispose to infection in the form of sinusitis and otitis media. Marked variability in self-reported sensitivity to indoor air pollutants has been observed, with females, younger individuals, and people with allergies reporting more symptoms. We report on a series of experiments designed to uncover demographic patterns of ‘nasal irritant sensitivity’, as well as potential mechanism(s) involved in observed chemesthetic variability.
Cometto-Muniz JE, Cain WS. Sensory irritation. Relation to indoor air pollution. Ann NY Acad Sci1992; 641: 137–151.
2.
Apter A, Bracker A, Hodgson M, Sidman J, Leung WY. Epidemiology of the sick building syndrome. J Allergy Clin Immunol1994; 94: 277–288.
3.
Fisk WJ, Mendell MJ, Daisey JM, Faulkner D, Hodgson AT, Nematollahi M, Macher JM. Phase 1 of the California Health Building Study: a summary. Indoor Air1993; 3: 246–245.
4.
Hodgson M.Sick building syndrome. Occup Med2000; 15: 571–585.
5.
Kreiss K.The epidemiology of building-related complaints and illness. Occup Med1989; 4: 575–592.
6.
Brasche S, Bullinger M, Morfeld M, Gebhardt HJ, Bischof W.Why do women suffer from sick building syndrome more often than men? – subjective higher sensitivity versus objective causes. Indoor Air2001; 11: 217–222.
7.
Cummings KM, Zaki A, Markello S.Variation in sensitivity to environmental tobacco smoke among adult non-smokers. Int J Epidemiol1991; 20: 121–125.
8.
Hall HI, Leaderer BP, Cain WS, Fidler AT. Personal risk factors associated with mucosal symptom prevalence in office workers. Indoor Air1993; 3: 206–209.
9.
Lundin L.Allergic and non-allergic students' perception of the same high school environment. Indoor Air1999; 9: 92–102.
10.
Mendell MJ. Non-specific symptoms in office workers: a review and summary of the epidemiologic literature. Indoor Air1993; 3: 227–236.
11.
Menzies D, Bourbeau J.The effect of varying levels of outdoor-air supply on the symptoms of sick building syndromeN Engl J Med1993; 328: 821–827.
12.
Stenberg B, Wall S.Why do women report ‘sick building symptoms’ more often than men?Soc Sci Med1995; 40: 491–502.
13.
Bullinger M, Morfeld M, von Mackensen S, Brasche S.The sick-building-syndrome – do women suffer more?Zentralbl Hyg Umweltmed1999; 202: 235–241.
14.
Ryan CM, Morrow LA. Dysfunctional buildings or dysfunctional people: an examination of the sick building syndrome and allied disorders. J Consult Clin Psychol1992; 60: 220–224.
15.
Nodelman V, Ultman JS. Longitudinal distribution of chlorine absorption in human airways: comparison of nasal and oral quiet breathing. J Appl Physiol1999; 86: 1984–1993.
16.
Laska M, Distel H, Hudson R.Trigeminal perception of odorant quality in congenitally anosmic subjects. Chem Senses1997; 22: 447–456.
17.
Doty RL, Cometto-Muniz JE, Jalowayski AA, Dalton P, Kendal-Reed M, Hodgson M.Assessment of upper respiratory tract and ocular irritative effects of volatile chemicals in humans. Crit Rev Toxicol2004; 34: 85–142.
Alarie Y, Luo JE. Sensory irritation by airborne chemicals: a basis to establish acceptable levels. In Barrow C ed. Toxicology of the nasal passages. Hemisphere Publishing, 1986.
20.
Cain WS. A functional index of human sensory irritation. In Indoor air '87: Proceedings of the Fourth International Conference on Indoor Air Quality and Climate. Institute for Water, Soil and Air Hygiene, 1987.
21.
Nielsen GD. Mechanisms of activation of the sensory irritant receptor by airborne chemicals. CRC Crit Rev Toxicol1991; 21: 183–208.
22.
Shusterman D, Murphy MA, Balmes J.Influence of age, gender, and allergy status on nasal reactivity to inhaled chlorine. Inhal Toxicol2003; 15: 1179–1189.
23.
Shusterman D, Tarun A, Murphy M-A, Morris J.Seasonal allergic rhinitic and normal subjects respond differentially to nasal provocation with acetic acid vapor. Inhal Toxicol2005; 17: 147–152.
24.
Cometto-Muniz JE, Cain WS. Trigeminal and olfactory sensitivity: comparison of modalities and methods of measurement. Int Arch Occup Environ Health1998; 71: 105–110.
25.
Shusterman DJ, Balmes JR. A comparison of two methods for determining nasal irritant sensitivity. Am J Rhinol1997; 11: 371–378.
26.
Kobal G.Is there directional smelling?Experientia1989; 45: 130–132.
27.
Wysocki CJ, Green BG, Malia TP. Monorhinal stimulation as a method for differentiating between thresholds for irritation and odor [Abstract]. Chem Senses1992; 17: 722–723.
28.
Shusterman D, Murphy MA, Balmes J.Differences in nasal irritant sensitivity by age, gender, and allergic rhinitis status. Int Arch Occup Environ Health2003; 76: 577–583.
29.
Shusterman D, Avila PC. Real-time monitoring of nasal mucosal pH during carbon dioxide stimulation: implications for stimulus dynamics. Chem Senses2003; 28: 595–601.
30.
Green BG, Dalton P, Cowart B, Shaffer G, Rankin K, Higgins J.Evaluating the ‘Labeled Magnitude Scale’ for measuring sensations of taste and smell. Chem Senses1996; 21: 323–334.
31.
Shusterman D.Individual factors in nasal chemesthesis. Chem Senses2002; 27: 551–564.
32.
Harkins SW, Davis MD, Buysh FM, Kasberger J.Suppression of first pain and slow temporal summation of second pain in relation to age. J Gerontol1996; 51A: M260–M265.
33.
Hummel T, Futschik T, Frasnelli J, Huttenbrink KB. Effects of olfactory function, age, and gender on trigeminally mediated sensations: a study based on the lateralization of chemosensory stimuli. Toxicol Lett2003; 140-141: 273–280.
34.
Wysocki CJ, Cowart BJ, Radil T.Nasal trigeminal chemosensitivity across the adult life span. Percept Psychophys2003; 65: 115–122.
35.
Cometto-Muniz JE, Noriega G.Gender differences in the perception of pungency. Physiol Behav1985; 34, 385–389.
Doerfler H, Hummel T, Klimek L, Kobal G.Intranasal trigeminal sensitivity in subjects with allergic rhinitis. Eur Arch Otorhinolaryngol2006; 263: 86–90.
38.
Kjaergaard S, Rasmussen TR, Molhave L, Pedersen OF. An experimental comparison of indoor air VOC effects on hayfever- and health subjects. In Proceedings of Healthy Buildings '95. Milan, 1995.
39.
Alimohammadi H, Silver WL. In vivo effects of casazepine on trigeminal nerve sensitivity to carbon dioxide and nicotine. Annual Meeting of the Association for Chemoreception Sciences, Sarasota, FL, April 2002. Abstract published in Chem Senses 2002; 27: 663-663.
40.
Abraham MH, Kumarsingh R, Cometto-Muniz JE, Cain WS. An algorithm for nasal pungency thresholds in man. Arch Toxicol1998; 72: 227–232.
41.
Cometto-Muniz JE, Cain WS, Abraham MH. Determinants for nasal trigeminal detection of volatile organic compounds. Chem Senses2005; 30: 627–642.
