This article presents a state-of-the-art review on automated control of blood sugar, especially for Type 1 diabetic patients. A brief introduction is provided so as to justify how this biomedical issue proves to be a control system problem in sense of blood glucose regulation. Various mathematical models and control strategies that have been used in recent research work for automated insulin delivery are discussed. An attempt has been made to provide a structural survey of research done till date in the development of artificial pancreas system. At the end, a general idea is presented on how control system can be designed for this biomedical control problem by employing Bergman’s minimal model for blood glucose regulation and an internal model–based proportional–integral controller is designed. The controller exhibits faster response in maintaining the blood glucose when compared with other existing techniques.
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