Donovanosis is a chronic genital ulcerative disease caused by the intracellular Gram-negative bacterium Klebsiella granulomatis, reported more frequently in people living with HIV/AIDS (PLHA). Here we present a case of relapsing donovanosis in a PLHA on second line antiretroviral therapy who had episodes of transient unexplained decrease in CD4 counts associated with rapid growth of the lesion and non-responsiveness to treatment followed by clinical resolution coinciding with recovery of the CD4 count.
Centers for Disease Control and Prevention. Guidelines for treatment of sexually transmitted diseases. MMWR2002; 51: 1–80.
2.
MerianosAGillesMChuahJ, et al.Ceftriaxone in the treatment of chronic donovanosis in central Australia. Genitourin Med1994; 70: 84–89.
3.
TanSLNeohCYTanHH. Rhinoscleroma: a case series. Singapore Med J2012; 53(2): e24–e27.
4.
O’FarrellN. Donovanosis. Sex Transm Infect2002; 78: 452–457.
5.
WuJJHuangDBPangKR, et al.Selected sexually transmitted diseases and their relationship to HIV. Clin Dermatol2004; 22(6): 499–508.
6.
SardanaKGargVKAroraP, et al.Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient. Dermatol Online J2008; 14(9): 8.
7.
Chandra GuptaTSRayuduTMurthySV. Donovanosis with auto-amputation of penis in a HIV-2 infected person. Indian J Dermatol Venereol Leprol2008; 74(5): 490–492.
8.
JamkhedkarPPHiraSKShroffHJ, et al.Clinico-epidemiologic features of granuloma inguinale in the era of acquired immune deficiency syndrome. Sex Transm Dis1998; 25: 196–200.
9.
JardinML. Donovanose em pacintes portradores de AIDS. Relato de dois casos. An Bras Dermatol Sifilogr1990; 65: 175–177.
10.
EngsigFNZangerleRKatsarouO, et al.Long-term mortality in HIV-positive individuals virally suppressed for >3 years with incomplete CD4 recovery. Clin Infect Dis2014; 58(9): 1312–1321.
