Prevalence,risk factors and impact of cellular immunity on intestinal parasitosis among people living with HIV at Auchi,Edo State,Nigeria

Abstract

This study was sought to determine the impact of CD4⁺ T-cell count and associated risk factors with intestinal parasitosis in people living with HIV (PLHIV) in Central Hospital, Auchi, Edo State, Nigeria. One hundred and seventy (170) HIV-seropositive subjects were enrolled in the study from 24 August 2015 to 22 January 2016. Sociodemographic data were assessed using structured questionnaires. Blood and stool samples were collected from every participant. CD4⁺ T-cell count and stool parasitology were performed. The prevalence of intestinal parasites was 44.7%. Helminthiasis (67%) was a predominant infection in the study, while 32.9% had protozoasis. Specifically, Ancylostoma duodenale (33.3%) was the most common helminth, and Trichuris trichiura (7.8%), the least. However, Strongyloides stercoralis, Ascaris lumbricoides and Hymenolepis nana were 13.7%, 31.5% and 13.7%, respectively. Cryptosporidium spp. (25.0%) was the only protozoan. Lower CD4⁺ T-cell count, ART naivety (OR = 2.62 p < 0.05), residence in a rural setting (OR = 0.89, p < 0.05), and farming occupation (OR = 1.70, p < 0.05) were associated with the prevalence of intestinal parasitosis among PLHIV. This study revealed a significantly high prevalence of intestinal parasitosis in ART naive PLHIV with reduced CD4⁺ count. Hence, it is recommended to frequently test for intestinal parasitosis and commencement of ART in all PLHIV to improve their health and longevity.

Keywords

intestinal parasitosis HIV Nigeria

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References

Bahrami

Haghighi

Zamini

, et al. Prevalence and associated risk factors of intestinal parasitic infections in Kurdistan province, northwest Iran. Cogent Med 2018; 5: 1–14. DOI: 10.1080/2331205x.2018.1503777.

Tiwari

Ghimire

Malla

, et al. Intestinal parasitic infection among the HIV-infected patients in Nepal. J Infect Dev Ctries 2013; 7: 550–555. DOI: 10.3855/jidc.2785 .

Assefa

Erko

Medhin

, et al. Intestinal parasitic infections in relation to HIV/AIDS status, diarrhea and CD4 T-cell count. BMC Infect Dis 2009; 9: 155. DOI: 10.1186/1471-2334-9-155 .

Kulkarni

Kairon

Sane

, et al. Opportunistic parasitic infections in HIV/AIDS patients presenting with diarrhoea by the level of immunesuppression. Indian J Med Res 2009; 130: 63–66.

UNAIDS . UNAIDS report shows that 19 million of the 35 million people living with HIV today do not know that they have the virus. Geneva: Press Release, http://www.unaids.org/en/resources/presscentre/pressreleaseandstatementarchive/2014/july/20140716prgapreport.

Federal Ministry of Health . National human immunodeficiency virus and acquired immunodeficiency syndrome and reproductive health survey 2012 (plus II): human immunodeficiency virus testing. J HIV Hum Reprod 2014; 2: 15. DOI: 10.4103/2321-9157.135744.

Boasso

Shearer

. Chronic innate immune activation as a cause of HIV-1 immunopathogenesis. Clin Immunol 2008; 126: 235–242.

McMichael

Borrow

Tomaras

, et al. The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol 2010; 10: 11–23. DOI: 10.1038/nri2674 .

, et al. Feline immunodeficiency virus in South America. Viruses 2012; 4: 383–396. DOI: 10.3390/v4030383 .