In this study, we addressed the recent concerns over the authenticity of generic pre-exposure prophylaxis (PrEP) purchased online by sampling 14 generic PrEPs from different manufacturers and suppliers and measuring tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) content using high-performance liquid chromatography. We confirmed that all the PrEP tablets contained 94.3% to 104.9% of the 300 mg of TDF claimed on the label and 97.3% to 104.4% of the 200 mg FTC claimed on the label.
BeyrerC.Strategies to manage the HIV epidemic in gay, bisexual, and other men who have sex with men. Curr Opin Infect Dis2014;
27: 1–8.
2.
van GriensvenFde Lind van WijngaardenJWBaralSet al.
The global epidemic of HIV infection among men who have sex with men. Curr Opin HIV AIDS2009;
4: 300–307.
3.
McCormackSDunnDTDesaiMet al.
Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet2016;
387: 53–60.
4.
GrantRMLamaJRAndersonPLet al.
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med2010;
363: 2587–2599.
5.
MolinaJ-MCapitantCSpireBet al.
On-demand preexposure prophylaxis in men at high risk for HIV-1 infection. N Engl J Med2015;
373: 2237–2246.
6.
World Health Organization. Department of HIV/AIDS. Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV 2015. Available from https://apps.who.int/iris/handle/10665/186275.
7.
WangXNwokoloNKorologou-LindenRet al.
InterPrEP: internet-based pre-exposure prophylaxis with generic tenofovir disoproxil fumarate/emtrictabine in London – analysis of pharmacokinetics, safety and outcomes. HIV Med2018;
19: 1–6.
VeroninMANguyenNT.Comparison of simvastatin tablets from the US and international markets obtained via the internet. Ann Pharmacother2008;
42: 613–620.
10.
VeroninMANutanMTDodlaU.Quantification of active pharmaceutical ingredient and impurities in sildenafil citrate obtained from the internet. Ther Adv Drug Saf2014;
5: 180–189.
11.
OnwujekweOKaurHDikeNet al.
Quality of anti-malarial drugs provided by public and private healthcare providers in south-east Nigeria. Malar J2009;
8: 22.
12.
BaertBAnnavarapuSBurvenichCet al.
Analytical, biopharmaceutical and regulatory evaluation of topical testosterone preparations. Eur J Pharm Biopharm2009;
72: 275–281.
13.
WHO. Guidelines on the conduct of surveys of the quality of medicines. WHO technical report series, no. 996, 2006, Annex 7.
