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Abstract

The mineral content of cancellous bone from sheep and pig vertebral bodies was determined by ashing at 800 °C. The results were compared with published results for human vertebral cancellous bone. The results for sheep (0.37 ± 0.06 g cm⁻³, mean ± standard deviation) were not significantly different (p = 0.127) to those from pigs (0.33 ± 0.03 g cm⁻³). The results from both species were significantly higher (p < 0.001) than those from human bones (0.15 ± 0.02 g cm⁻³). This means that cancellous bone from sheep and pig vertebral bodies is not a good model for corresponding human bone. However, sheep and pig bone are useful, for example, for providing stringent tests of cutting instruments to be used in human spinal surgery.

Keywords

Animal models bone mineral spinal surgery vertebrae

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References

Kettler

Liakos

Haegele

. Are the spines of calf, pig and sheep suitable models for pre-clinical implant tests?Eur Spine J 2007; 16(12): 2186–2192.

Patel

PSD

Shepherd

DET

Hukins

DWL

. Compressive properties of commercially available polyurethane foams as mechanical models for osteoporotic human cancellous bone. BMC Musculoskelet Disord 2008; 9: 137.

Patel

PSD

Shepherd

DET

Hukins

DWL

. The effect of screw insertion angle and thread type on the pullout strength of bone screws in normal and osteoporotic bone models. Med Eng Phys 2010; 32(8): 822–828.

Jabbary Aslani

Hukins

DWL

Shepherd

DET

. Design of a surgical instrument for removing bone to provide screw access to a spinal fusion cage. J Engineering in Medicine (in press).

Reid

Meakin

Robins

. Sheep lumbar intervertebral discs as models for human discs. Clin Biomech 2002; 17(4): 312–314.

Currey

. The relationship between the stiffness and mineral content of bone. J Biomech 1969; 2(1): 477–480.

Gong

Arnold

Cohn

. Composition of trabecullar and cortical bone. Anatom Rec 1964; 149(3): 325–332.

Coats

Zioupos

Aspden

. Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis. Calcif Tissue Int 2003; 73(1): 66–71.

Holmes

Hukins

DWL

Freemont

. End-plate displacement during compression of lumbar vertebra-disc-vertebra segments and the mechanism of failure. Spine 1993; 18(1): 128–135.

10.

Mkukuma

Skakle

JMS

Gibson

. Effect of proportion of organic material in bone on thermal decomposition of bone mineral: an investigation of a variety of bones from different species using thermogravimetric analysis coupled to mass spectrometry, high-temperature x-ray diffraction and Fourier transform infrared spectroscopy. Calcif Tissue Int 2004; 75(4): 321–328.

11.

Haddad

McNulty

Trebes

. Ultrahigh-resolution X-ray tomography. Science 1994; 226(5188): 1213–1215.

12.

Ostadi

Rama

Liu

. Nanotomography based study of gas diffusion layers. Microelectron Eng 2010; 87(5–8): 1640–1642.

13.

Ostadi

Rama

Liu

. 3D reconstruction of a gas diffusion layer and a microporous layer. J Membrane Sci 2010; 351(1–2): 69–74.

14.

Rama

Liu

Chen

. An X-ray tomography based lattice Boltzmann simulation study on gas diffusion layers of polymer electrolyte fuel cells. J Fuel Cell Sci Tech 2010; 7(3): 031015.

15.

Bland

. An introduction to medical statistics. 4th ed. Oxford: Oxford University Press, 1995.

16.

Bryce

Aspden

Wytch

. Stiffening effect of cortical bone on vertebral cancellous bone in situ. Spine 1995; 20(9): 999–1003.

17.

Schmidt

Richter

Claes

. Limitations of the porcine cervical spine in evaluating spinal implants in comparison with human cervical spinal segments. A biomechanical in vitro comparison of human and porcine cervical spine specimens with different instrumentation techniques. Spine 2005; 30(11): 1275–1283.

Applicability of sheep and pig models for cancellous bone in human vertebral bodies

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